Protein Alignment LTBP1 and lin-12

DIOPT Version :10

• Sequence 1: XP_011531155.1
• Gene: LTBP1 / 4052
• HGNCID: 6714
• Length: 1722
• Species: Homo sapiens
• Sequence 2: NP_499007.1
• Gene: lin-12 / 176282
• WormBaseID: WBGene00003001
• Length: 1429
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 230/903 - (25%)
• Similarity: 333/903 - (36%)
• Gaps: 304/903 - (33%)

Human   884 ICGA-GHCINLPVR-----YTCICYEGY--RFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFL 940
            |||. |||...||.     |.|.|.||:  .:.|||  | |:.:| .....|...:....|   .
 Worm    28 ICGRNGHCHAGPVNGTQTSYWCRCDEGFGGEYCEQQ--C-DVSKC-GADEKCVFDKDYRME---T 85

Human   941 CICPAGFMASEEGTNC-IDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECL 1004
            |:|          .:| |:.:..|:|.                  |.|||         ..|:|.
 Worm    86 CVC----------KDCDINGNSLLKPS------------------CPSGY---------GGDDCK 113

Human  1005 N-----PSTCPD-EQCVNSPGSYQCVPCTEGFRGWNGQC-LDVDECLE-PNVCAN-GDCSNLEGS 1060
            .     ||.|.: .||:.:....:|. |.:||:|  .:| |||:||.| .|.|.| ..|.|..|:
 Worm   114 TQGWCYPSVCMNGGQCIGAGNRAKCA-CPDGFKG--ERCELDVNECEENKNACGNRSTCMNTLGT 175

Human  1061 YMCSCHKGY----------TRT-------------PDHKHCRDIDECQQGNLCVNGQCKNTEGSF 1102
            |:|.|.:|:          |.|             .||...|.: .||.|..|       .:.|.
 Worm   176 YICVCPQGFLPPDCLKPGNTSTVEFKQPVCFLEISADHPDGRSM-YCQNGGFC-------DKASS 232

Human  1103 RCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHC-EDINEC 1166
            :|.|..||..|.. :..|..|.|. .:.|:||.|.:..|.|||:||.||.    |.:| |..:.|
 Worm   233 KCQCPPGYHGSTC-ELLEKEDSCA-SNPCSHGVCISFSGGFQCICDDGYS----GSYCQEGKDNC 291

Human  1167 LEDKSVCQRGD-CINTAGSYDCTCPDGFQLDDNKT---CQDINECEHPGLCGPQGECLN---TEG 1224
            :.:|  |:.|. |||...||.|.||      ..:|   |:.::....|.:|. .|.|::   :|.
 Worm   292 VNNK--CEAGSKCINGVNSYFCDCP------PERTGPYCEKMDCSAIPDICN-HGTCIDSPLSEK 347

Human  1225 SFHCVCQQGFSISADGRTCE-DIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVD- 1287
            :|.|.|:.|:    :|..|| |.:||::..:|.::|.|.|..|||||.|.:||    .|:.|.:
 Worm   348 AFECQCEPGY----EGILCEQDKNECLSENMCLNNGTCVNLPGSFRCDCARGF----GGKWCDEP 404

Human  1288 VNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYY 1352
            :|.|:       :..||| :|:  |:   ...::||:. ||::...         .|..:|||..
 Worm   405 LNMCQ-------DFHCEN-DGT--CM---HTSDHSPVC-QCKNGFI---------GKRCEKECPI 446

Human  1353 NLNDASLCDNVLAPNVTKQE---CC----CTSGVGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVP 1410
            ...... ||..|...:..::   |.    |.||.     |   .||...|....|:..|.
 Worm   447 GFGGVR-CDLRLEIGICSRQGGKCFNGGKCLSGF-----C---VCPPDFTGNQCEVNRKN----- 497

Human  1411 AGESSSEAGGENYKDADECLLFGQEICKNGFCL--NTRPGYECYCKQGTYYDPVKLQCFDMDECQ 1473
             |:||.   .||...:|.|:       .|..|:  :...||.|.||||          |:.|.|:
 Worm   498 -GKSSL---SENLCLSDPCM-------NNATCIDVDAHIGYACICKQG----------FEGDICE 541

Human  1474 -DPSSCIDGQCVN------TEGSYNCFCTHPMVLDASEK----RCIRPAESNEQIEETDVYQDLC 1527
             ....|::..|.|      ...|::|.|......:..|:    ||::....|..
 Worm   542 RHKDLCLENPCSNGGVCHQHRESFSCDCPPGFYGNGCEQEKMFRCLKSTCQNGG----------- 595

Human  1528 WEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRD 1592
                    ||    :.::....:|.|.||.: |.:|..             .|.:||
 Worm   596 --------VC----INEEEKGRKCECSYGFS-GARCEE-------------KINLTG-------- 626

Human  1593 ALVDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRC-VRVQEGYTCDCFDGYHLDT 1656
                |:|           :|..|.|.             ||..:| .|..:| .||.      |.
 Worm   627 ----FTE-----------KDSLLRSV-------------CEKRKCSERANDG-NCDA------DC 656

Human  1657 AKMTC-VDVNECDELNNRMSLCK----------NAKCINTDGSYKCL-----CLPGYV 1698
            ....| .|..:|.......|.|:          |..|.....:.:||     |||..|
 Worm   657 NYAACKFDGGDCSGKREPFSKCRYGNMCADFFANGVCNQACNNEECLYDGMDCLPAVV 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LTBP1	XP_011531155.1	TB	567..602	CDD:459903
		EGF_CA	626..>656	CDD:214542
		TB	688..729	CDD:459903
		PHA03247	<742..869	CDD:223021
		EGF_CA	916..957	CDD:214542	7/41 (17%)
		EGF_CA	958..998	CDD:214542	6/39 (15%)
		EGF_CA	999..1032	CDD:238011	11/38 (29%)
		EGF_CA	1039..1078	CDD:214542	19/63 (30%)
		EGF_CA	1080..1111	CDD:214542	8/30 (27%)
		EGF_CA	1121..1161	CDD:214542	16/40 (40%)
		EGF_CA	1162..1192	CDD:429571	12/30 (40%)
		EGF_CA	1203..1244	CDD:214542	10/43 (23%)
		EGF_CA	1245..1286	CDD:214542	16/40 (40%)
		TB	1360..1402	CDD:459903	12/48 (25%)
		TB	1536..1578	CDD:459903	8/41 (20%)
		EGF_CA	1663..>1697	CDD:214542	11/48 (23%)
lin-12	NP_499007.1	EGF_CA	152..189	CDD:238011	15/36 (42%)
		EGF_2	220..245	CDD:400365	10/31 (32%)
		EGF_CA	252..285	CDD:238011	15/37 (41%)
		EGF_CA	293..323	CDD:238011	12/37 (32%)
		EGF_CA	365..401	CDD:238011	16/39 (41%)
		EGF_CA	505..541	CDD:238011	14/52 (27%)
		EGF_CA	545..579	CDD:238011	6/33 (18%)
		NL	635..668	CDD:197463	11/52 (21%)
		Notch	675..709	CDD:459658	6/33 (18%)
		Notch	715..750	CDD:459658	230/903 (25%)
		NOD	753..807	CDD:462014
		NODP	842..898	CDD:462229
		ANK repeat	1052..1091	CDD:293786
		ANKYR	1070..1295	CDD:440430
		ANK repeat	1093..1124	CDD:293786
		ANK repeat	1126..1160	CDD:293786
		ANK repeat	1162..1201	CDD:293786
		ANK repeat	1203..1238	CDD:293786
		ANK repeat	1240..1271	CDD:293786