Protein Alignment LTBP1 and F55H12.3

DIOPT Version :10

• Sequence 1: XP_011531155.1
• Gene: LTBP1 / 4052
• HGNCID: 6714
• Length: 1722
• Species: Homo sapiens
• Sequence 2: NP_492397.4
• Gene: F55H12.3 / 172702
• WormBaseID: WBGene00010134
• Length: 2957
• Species: Caenorhabditis elegans
• Alignment Length: 1762
• Identity: 361/1762 - (20%)
• Similarity: 526/1762 - (29%)
• Gaps: 676/1762 - (38%)

Human   320 ISGEQST--------EGSFPLRYVQDQVAAPFQLS-----NHTGRIKVVFTPSICKVTCTKGSCQ 371
            :|..|||        .|..|...|..|.|.||:..     ||..           .:|.|.|...
 Worm   520 VSKNQSTYVTNLGVLTGFGPTTVVIHQSAEPFEFHSIYKINHND-----------VITTTPGRIL 573

Human   372 NSCEKGNTTTLISENGHAAD-TLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIP-- 433
            :..|       |.:.....| .:|.|.                ||       ||:.|.||::|
 Worm   574 DESE-------IDQEQPTTDPIITPTT----------------SS-------PNWDGVLCKLPTV 608

Human   434 VHGASVPKLYQHSQQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIH------------ 486
            |.|..:....::      .||:.|:         :...||..:...|.|:..:
 Worm   609 VDGYIINVFLRY------ILGSKVV---------IDCSQGFALSSLPYIIQCNSNGQWVDEDGKT 658

Human   487 --VKHPPEASVQIHQVSRIDGPTGQKTKEAQPGQSQVSYQGLPVQKTQT---------------- 533
              ..||   :|:.:|:...:....:...|..|..:..||..:...:..|
 Worm   659 FDADHP---TVECYQIDCSNKTPVENKYELTPDNNHTSYGTMRKYQNLTNFGFGAFCVCGDERSQ 720

Human   534 ------------IHSTYSHQQVIP---------------HVYPVAAKTQLGRCFQETIGSQCGKA 571
                        :.:..::..::|               :|:|.....|: .|.          .
 Worm   721 PDEWICYNTEGLMTNPINNACMLPEAQDALFVKQDPTDGYVFPTGYMIQM-TCM----------I 774

Human   572 LPGLSKQEDC-CGTVGTSWG-------FNKCQKCPKKPSY------HGYN------QMMECLPGY 616
            .|.|.|...| .|...||.|       | :|. |...|::      |||.      ...:|..||
 Worm   775 CPSLIKYYTCEFGLWKTSDGSIQPYDTF-ECD-CTTDPNFIDPCLPHGYYVQHNGFYSCQCDVGY 837

Human   617 KRV----NNTFCQDINECQLQG-VCPN-GECLNTMGSYRCTCKIGF------GPD-PTFS----- 663
            |.|    |...|.|.:||:.:. .|.: ..|.||.|.:.|.|.:|:      .|| .|::
 Worm   838 KYVLLDSNVGKCVDRDECEEKSDYCDSFATCNNTDGGFECHCPVGYHLYNANSPDLSTWARIYDD 902

Human   664 -----SCVPD-----------------PPVISEEKGPCYR------------LVSS-GRQCMHPL 693
                 |||..                 |||..:    .||            |.|| |..|
 Worm   903 LIDGYSCVETVCKYDINWAVYGLDVIAPPVYPQ----IYRSGDYMDYLYANDLCSSKGFPC---- 959

Human   694 SVHLTKQLCCCSVGKAWGPHCEKCPLPGTAAFKEICPG--GMGYT----------------VSGV 740
             |...::.|   :|:      ..||.|...|   .||.  ...||                |..|
 Worm   960 -VFQFQEYC---LGE------NLCPFPNPVA---ACPALDSTIYTYKIEASPSFHVFQIIDVECV 1011

Human   741 HRR-----RP----------------IHHHVGKGPVFVKPKNTQPVAKSTHPPPLPAKEEPVEAL 784
            :..     ||                |:........|:||    |:.......||....|....:
 Worm  1012 NSAMLMIGRPRVFCTSESKWDMLPICIYQSCSDPRQFIKP----PLLIDRVDRPLGHGFEYQTVI 1072

Human   785 TFSREHG----PGVAEPEVATAPPEKEIPSLDQEKTKLEPGQPQLSPGISTIHLHPQFPGIVIEK 845
            .|..|:|    ||.....:.....:.|....|.....:....|..:|. ||
 Worm  1073 YFKCENGYMLSPGSGSESITCIRYDDEYQWSDAIPVCISTTTPSSTPS-ST-------------- 1122

Human   846 TSPPVP----VEVAPEASTSSASQ-----------------VIAPTQV-TEINEC------TVNP 882
            :||.:|    .|..|.|:.||.:.                 ||..:.: .|||..      |...
 Worm  1123 SSPTLPSGSSTEYTPRATQSSTTTSYGSTLSSDFSNFHDDVVIEGSMIFEEINALDRQEIWTKTA 1187

Human   883 D-ICGAGHCI----NLPVRYTCICYEGYRFSEQQRKCVDIDEC-TQVQHLCSQGRCENTEG---- 937
            | |.....||    ..|:.:..........|:|....:|:.:| :.||    .|...:|:|
 Worm  1188 DWIWTPSGCIVHQWTYPISFMVTSIPIVLNSDQIELLIDVSQCNSNVQ----VGIASSTDGFIPP 1248

Human   938 ----------------------------------SFLCICPAGFMASEEGTNCIDVDEC------ 962
                                              .::.||  |....|:..|.:|.:..
 Worm  1249 ISDFRTVINTTSSGSFVVNLRNLKSHLALSISANGYVQIC--GVTIREKMCNEVDYNGLHLKSSA 1311

Human   963 ---LR---PDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECL-NPS-TCPDEQCVNSPG 1019
               :|   |..||:...:..|..    |||:     |||.......|| ||. .||..:.:  |.
 Worm  1312 PFKMRRYLPATCGQSKRITQVNG----YCDN-----QRGWVIQNTPCLCNPQPPCPSTELL--PQ 1365

Human  1020 SYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGY-----TRTPDHKHCR 1079
            ..|...||                  .|.|.||.|..:.|.:.|:|::.:     ..||
 Worm  1366 RDQIGDCT------------------LNSCQNGVCLQMNGMHDCACNEYFIVDRENGTP------ 1406

Human  1080 DIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQ----CEDIDE----CQHRHLCAHGQC 1136
               .|:..:.....|.:|:          ||..|..::.    |.:::|    ||:     .||.
 Worm  1407 ---FCKPNHCLFTNQTRNS----------GYDCSTGRENALFLCPNLNEFGDFCQY-----EGQL 1453

Human  1137 RNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDD-NKT 1200
            .|  .|:..:...|...:...:.||.::...                    ..|:.|.:.: ..|
 Worm  1454 YN--NSYTYILSAGIENAIATNLCESLDTLY--------------------AVPNTFCVQNPTST 1496

Human  1201 CQDINECEHPGLC--GPQGECLNT--EGSFHCVCQQGFSISADGRTCEDIDECVNNT----VCDS 1257
            ...|:.|:   .|  |...|.||.  :|...|:|.|.:.    ||.|:....|.|.|    :|.:
 Worm  1497 TPSIHRCD---FCYGGENCEFLNPPYQGGAWCICAQDWY----GRQCDVSKFCFNGTNDNYICQN 1554

Human  1258 HGFCDNTAGSFR-CLCYQGFQAPQDGQGC---VDVNECELLSGVCGEAFCENVEGSFLCVCADEN 1318
            .|.|:.   ..| |.|...|    .|..|   :|.:.|.|....|....|........|.|.|..
 Worm  1555 GGRCNK---DLRLCECLSSF----TGAFCETAIDESNCALDEKDCVFGLCRRENAQVYCNCYDGY 1612

Human  1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGW-G 1382
            .:.|  .|.|  ..:.|: ..::.|.::...|.:|            .|:..:.|.|||. || |
 Worm  1613 MKDS--LGNC--TLAWDM-CSLNNPCQQNGYCNFN------------QNIGDEICDCTSS-GWLG 1659

Human  1383 DNCEIFP-------C--PVLGTAEFT--EMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEI 1436
            |:|||.|       |  .|.....||  ..|....||  :|:..|:.       .|:|..   |.
 Worm  1660 DHCEIQPKLDNCLYCQNSVKCFDTFTNYSRCQCAPGF--SGDYCSDL-------IDDCFF---EP 1712

Human  1437 CKNG-----FCLNTR-----PGYECYCKQGTYY-----DPVKLQCFDMDECQDPSSC----ID-G 1481
            |.||     |..||.     ..|.|.|:.| |:     ..:...|.|:..||:..:|    .| .
 Worm  1713 CFNGGTCSIFNYNTTTKVSIESYNCTCQTG-YFGTNCESRIHPSCTDLITCQNGGTCQLTSFDTA 1776

Human  1482 QCVNTEGSYNCFCTHPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQ- 1545
            .|..|:..|..:|         ||.|          .|..|:...|                ||
 Worm  1777 VCQCTDQFYGIYC---------EKSC----------SEQCVHSSGC----------------KQS 1806

Human  1546 ---TTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPV-------TGRRQPYGRDALVDFSEQ 1600
               |.:.||   |......:|        |:...:|...:       |........|.:
 Worm  1807 SNGTVFCEC---YDGFTSTRC--------DEVCDVCKANILLCQNSGTCNSTTQSCDCI------ 1854

Human  1601 YTPEADPYFIQDRFLNSFEELQAEECGI-LNGCENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDV 1664
                       |.|..::.|.....|.. |..|:||.....:.| .|.|...|..|
 Worm  1855 -----------DYFSGTYCERNENLCETNLVVCKNGGTCNPKTG-LCVCLPDYTGD--------- 1898

Human  1665 NECDELNNRMSLCKNAKCIN----TDGSYKCLCLPGYVPSDKPNY----CT---PLNTA----LN 1714
             .||   |::..|.:..|.|    .|.:..|.|||| ...|:..|    ||   |..||    ||
 Worm  1899 -YCD---NQIHSCSDINCFNGGTCIDYNATCACLPG-TTGDRCQYLGQPCTIYLPNGTATPYCLN 1958

Human  1715 LEKDSDL 1721
            ..|..||
 Worm  1959 EGKCLDL 1965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LTBP1	XP_011531155.1	TB	567..602	CDD:459903	11/42 (26%)
		EGF_CA	626..>656	CDD:214542	10/31 (32%)
		TB	688..729	CDD:459903	8/40 (20%)
		PHA03247	<742..869	CDD:223021	31/172 (18%)
		EGF_CA	916..957	CDD:214542	12/79 (15%)
		EGF_CA	958..998	CDD:214542	12/51 (24%)
		EGF_CA	999..1032	CDD:238011	10/34 (29%)
		EGF_CA	1039..1078	CDD:214542	10/43 (23%)
		EGF_CA	1080..1111	CDD:214542	4/30 (13%)
		EGF_CA	1121..1161	CDD:214542	8/43 (19%)
		EGF_CA	1162..1192	CDD:429571	1/29 (3%)
		EGF_CA	1203..1244	CDD:214542	13/44 (30%)
		EGF_CA	1245..1286	CDD:214542	12/48 (25%)
		TB	1360..1402	CDD:459903	17/53 (32%)
		TB	1536..1578	CDD:459903	8/45 (18%)
		EGF_CA	1663..>1697	CDD:214542	11/37 (30%)
F55H12.3	NP_492397.4	LDLa	185..217	CDD:238060
		CCP	604..651	CDD:214478	10/61 (16%)
		EGF_CA	851..884	CDD:214542	11/32 (34%)
		CCP	<1066..1110	CDD:153056	8/43 (19%)
		HYR	2235..2315	CDD:460572
		TNFRSF	2510..2657	CDD:473981
		Ephrin_rec_like	2517..2567	CDD:429604
		CRD2	2530..2590	CDD:276900
		Ephrin_rec_like	<2640..2676	CDD:429604