DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LTBP1 and ltbp1

DIOPT Version :9

Sequence 1:	XP_011531155.1	Gene:	LTBP1 / 4052	HGNCID:	6714	Length:	1722	Species:	Homo sapiens
Sequence 2:	XP_012819247.1	Gene:	ltbp1 / 100488719	XenbaseID:	XB-GENE-488058	Length:	1698	Species:	Xenopus tropicalis

Alignment Length:	1763	Identity:	1088/1763 - (61%)
Similarity:	1307/1763 - (74%)	Gaps:	116/1763 - (6%)

- Green bases have known domain annotations that are detailed below.

Human     7 RWGLLLWAGLLASSA----HGRLRRITYVVHPG-PGL--AAGALPLSGPPRSRTFNVALNARYSR 64
            |||::|.|.:|.|||    ..|:||||||:.|| ||:  ....:|||       .||.|
Frog     5 RWGVVLCAAVLLSSALANIESRVRRITYVLQPGPPGIYQQQHPVPLS-------HNVVL------ 56

Human    65 SSAAAGAPSRASPGVPSERTRRTSKPGGAALQGLRPPPPPPPEPARPAVPGGQLHPNPGGHPAAA 129
            ||...||.|..|   ..||:||.|:...:           |....|..:||..          ||
Frog    57 SSGQQGAGSHMS---TQERSRRMSRVIAS-----------PSLVQRQQIPGQN----------AA 97

Human   130 PFTKQGRQVVRSKVPQETQSGGGSRLQVHQKQQLQGVNVCGGRCCHGWSKAPGSQRCTKPSCVPP 194
            ....|.....|....|:... ..|..|...|.|.||||:|||:|||||||:|||:|||||:|.||
Frog    98 SMVSQYYSFSRGSAQQDAHR-SPSLTQTQHKFQHQGVNICGGKCCHGWSKSPGSERCTKPNCSPP 161

Human   195 CQNGGMCLRPQLCVCKPGTKGKACETIAAQDTSSPVFGGQSPGAASSWGP----PEQAAKHTSSK 255
            ||||||||||.|||||||||||.||...:|||:....|||..|..:...|    |:|||..::.:
Frog   162 CQNGGMCLRPHLCVCKPGTKGKVCEEGPSQDTTFTATGGQGNGVPAHAPPPRPIPQQAAPQSTPQ 226

Human   256 KADTLPRVSPVAQMTLTLKPKPSVGLPQQIHSQVTPLSSQSVV--IHHGQTQEYVLKPKYFPAQK 318
            |..  ...|||.|:||.||.|....:.||:...|....||.:.  :.|||||::::|||||.:.|
Frog   227 KVS--QESSPVGQVTLALKQKSPTLVTQQVQPMVMSPQSQPLTMNLQHGQTQQFMIKPKYFSSSK 289

Human   319 GI-SGEQSTEGSFPLRYVQDQVAAPFQ-LSNHTGRIKVVFTPSICKVTCTKGSCQNSCEKGNTTT 381
            .: .||||||||.|||...|.:::..| |.|.|||||||||||||||||||..||||||||||||
Frog   290 KVLLGEQSTEGSLPLRAGLDNLSSHIQSLGNQTGRIKVVFTPSICKVTCTKHHCQNSCEKGNTTT 354

Human   382 LISENGHAADTLTATNFRVVICHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGASVPKLYQHS 446
            |||||||:|||||::|||||||||||||||||::||||||||||||||||||:.. .:.|.|.|.
Frog   355 LISENGHSADTLTSSNFRVVICHLPCMNGGQCTARDKCQCPPNFTGKLCQIPLQN-GLQKQYPHQ 418

Human   447 QQPGKALGTHVIHSTHTLPLTVTSQQGVKVKFPPNIVNIHVKHPPEASVQIHQVSRIDGPTGQKT 511
            |...||.|:.|||||||||||||.|||:||.||||:||||||||||||||.||||||:..:..:.
Frog   419 QPAQKATGSQVIHSTHTLPLTVTGQQGIKVNFPPNMVNIHVKHPPEASVQFHQVSRIESSSSTQK 483

Human   512 KEAQPGQSQVSYQGLPVQKTQTIHSTYSHQQVIPHVYPVAAKTQLGRCFQETIGSQCGKALPGLS 576
            |::|.||:|.||..  .||.|..|:||.|||.||:|||::.|.|||||||||:||||||.|||||
Frog   484 KDSQIGQTQFSYHS--TQKHQLPHNTYPHQQFIPNVYPISTKNQLGRCFQETVGSQCGKPLPGLS 546

Human   577 KQEDCCGTVGTSWGFNKCQKCPKKPSYHGYNQMMECLPGYKRVNNTFCQDINECQLQGVCPNGEC 641
            ||||||||||||||||||.|||||.|.|..:|:|||..||:|:|.|||||||||.:|||||||:|
Frog   547 KQEDCCGTVGTSWGFNKCMKCPKKTSQHVSSQIMECPQGYRRINATFCQDINECHMQGVCPNGDC 611

Human   642 LNTMGSYRCTCKIGFGPDPTFSSCVPD-PPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCS 705
            |||||||||.||:|:.||.:.||||.| .|::|||||||||..|.|:|||||::|.|::|:|||:
Frog   612 LNTMGSYRCKCKVGYVPDLSLSSCVVDNNPIVSEEKGPCYRFFSPGKQCMHPIAVQLSQQICCCT 676

Human   706 VGKAWGPHCEKCPLPGTAAFKEICPGGMGYTVSGVHRRRPIHHHVGKGPVFVKPKN----TQPVA 766
            |||||||:|::||:||||||||||||||||||..|.|          .|:.|.|.|    .||..
Frog   677 VGKAWGPYCDRCPVPGTAAFKEICPGGMGYTVPNVPR----------NPIRVPPPNRPITVQPPV 731

Human   767 KSTHPPPLPAKEEPVEALTFSREHGPGVAEPE-VATAPPEKEIPSLDQEKTKLEPGQPQLSPGIS 830
            ::|| .|:..||||:|||:.|..:.|.|.|.: .||...:..:|.  :|:..:|.||||:|||||
Frog   732 RTTH-APIVTKEEPIEALSVSERNYPHVPERKGEATDDDQAHVPF--EERRVVEGGQPQVSPGIS 793

Human   831 TIHLHPQFPGIVIEKTSPPVPVEVAPEASTSSASQVIAPTQVTEINECTVNPDICGAGHCINLPV 895
            |::|..||| :|:||:||||||.:||:.||:|||||||||||||||||.|:.:|||.|:||||||
Frog   794 TVNLDGQFP-VVVEKSSPPVPVALAPDVSTASASQVIAPTQVTEINECAVDVNICGEGNCINLPV 857

Human   896 RYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVD 960
            .|||:|:.||:.:||:.|||||:||.:..||||.||||||:|.|||||.||:||:|:|.:|:||:
Frog   858 GYTCLCFTGYKLNEQKTKCVDINECAEDPHLCSHGRCENTKGRFLCICHAGYMANEQGIDCVDVN 922

Human   961 ECLRPDVCGE-GHCVNTVGAFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCV 1024
            |||||..|.| |.|:||:|:|.||||:.|:|..|||.||||:||||..|||.::||||.|||.||
Frog   923 ECLRPHACEEDGLCINTIGSFGCEYCEKGFRHNQRGECEDINECLNQLTCPHDRCVNSVGSYSCV 987

Human  1025 PCTEGFRGWNGQCLDVDECLE-PNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGN 1088
            ||.:||.|.||||.|::||.| .:||||||||||||||.|:||:||..|.|.|.|.||:|||.|.
Frog   988 PCPDGFNGLNGQCFDINECQEDTSVCANGDCSNLEGSYRCTCHRGYDVTSDGKQCIDINECQSGT 1052

Human  1089 LCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRA 1153
            ||:||.|:||||||.|:|.:||||:.:.|||.||||||:.:||::||||||.|||.|:|.|||:.
Frog  1053 LCLNGLCQNTEGSFECSCNEGYQLAPSGDQCHDIDECQNTNLCSNGQCRNTRGSFSCICHQGYKV 1117

Human  1154 SGLGDHCEDINECLEDKSVC-QRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQG 1217
            |..|:.||||:||.|:..|| ..|.|.||.|||:|||||||.|.|...||||||||.|.||.|.|
Frog  1118 SADGEQCEDIDECQEEAEVCLGGGSCHNTDGSYECTCPDGFLLVDGIRCQDINECEQPDLCNPNG 1182

Human  1218 ECLNTEGSFHCVCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDG 1282
            ||||||||:||:|:|||:.||:||:|||:|||.|.|.|.|.|.|:||.||:|||||||:|...||
Frog  1183 ECLNTEGSYHCICEQGFTTSANGRSCEDVDECANTTQCGSQGICENTDGSYRCLCYQGYQDSFDG 1247

Human  1283 QGCVDVNECELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRSR----------TSTD-- 1335
            ||||||||||:||||||||.||||||||||:|.||:|||.||||.||:.          ::||
Frog  1248 QGCVDVNECEMLSGVCGEARCENVEGSFLCLCTDESQEYDPMTGHCRNHNLHGINSFGDSNTDSL 1312

Human  1336 -------LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGVGWGDNCEIFPCPVL 1393
                   :..:.|:..|::|:||||:.....|.||||.||:|||||||.|.||||||||:||||:
Frog  1313 LNAFSPSVTHNTDENDEDQKDCYYNIIGDDFCQNVLAANVSKQECCCTLGAGWGDNCEIYPCPVI 1377

Human  1394 GTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICKNGFCLNTRPGYECYCKQGTY 1458
            |:.|||||||.|||::|:.||..|....:|:|||||:|||:||||||:||||...||||||||||
Frog  1378 GSDEFTEMCPGGKGYIPSKESMYEGNDLSYQDADECMLFGKEICKNGYCLNTESSYECYCKQGTY 1442

Human  1459 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRCI--RPAESNEQIEETD 1521
            ||||||||.|.:||:||||||||||:|.||||:|||||||:||.|.||||  :|.:::|..||||
Frog  1443 YDPVKLQCIDNNECEDPSSCIDGQCINNEGSYSCFCTHPMILDESGKRCIQPKPVDTSEPTEETD 1507

Human  1522 VYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCLYGEAWGMQCALCPLKDSDDYAQLCNIPVTGRR 1586
            ||||.||:.||:|:|||:||||::|||||||||:||||||||||||.|||:|||:|||:..   |
Frog  1508 VYQDFCWQELSEEFVCSQPLVGRRTTYTECCCLFGEAWGMQCALCPTKDSEDYAELCNLQY---R 1569

Human  1587 QPYGRDALVDFSEQYTP-EADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFD 1650
            :|||.|||:|   .||. ::.||.|.:|:  |:||||||||||||||||||||||||||||||||
Frog  1570 RPYGHDALID---PYTSHDSGPYEIPERY--SYEELQAEECGILNGCENGRCVRVQEGYTCDCFD 1629

Human  1651 GYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGYVPSDKPNYCTPLNTALNL 1715
            |||||.|||||||||||:|||::||||||||||||:|||||:|||||.||.|||||    ||||.
Frog  1630 GYHLDMAKMTCVDVNECNELNSKMSLCKNAKCINTEGSYKCVCLPGYKPSAKPNYC----TALNS 1690

Human  1716 EK-DSDLE 1722
            :| ||:||
Frog  1691 DKDDSELE 1698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LTBP1	XP_011531155.1	EGF_CA	626..>656	CDD:214542	24/29 (83%)
		TB	689..724	CDD:279073	23/34 (68%)
		cEGF	897..919	CDD:289433	13/21 (62%)
		EGF_CA	916..956	CDD:284955	26/39 (67%)
		EGF_CA	958..998	CDD:214542	24/40 (60%)
		EGF_CA	999..1032	CDD:238011	22/32 (69%)
		EGF_CA	1039..1078	CDD:214542	26/39 (67%)
		EGF_CA	1080..1111	CDD:214542	20/30 (67%)
		EGF_CA	1121..1161	CDD:214542	24/39 (62%)
		EGF_CA	1162..1202	CDD:214542	23/40 (58%)
		EGF_CA	1203..1244	CDD:214542	29/40 (73%)
		EGF_CA	1245..1286	CDD:214542	26/40 (65%)
		TB	1360..1397	CDD:279073	28/36 (78%)
		TB	1537..1573	CDD:279073	30/35 (86%)
		EGF_CA	1663..>1697	CDD:214542	28/33 (85%)
ltbp1	XP_012819247.1	EGF_CA	596..>626	CDD:214542	24/29 (83%)
		TB	659..701	CDD:366245	30/41 (73%)
		cEGF	858..881	CDD:372248	13/22 (59%)
		vWFA	<872..916	CDD:381780	29/43 (67%)
		EGF_CA	920..957	CDD:214542	21/36 (58%)
		EGF_CA	962..>993	CDD:214542	20/30 (67%)
		EGF_CA	1002..1033	CDD:238011	21/30 (70%)
		cEGF	1024..1047	CDD:372248	13/22 (59%)
		EGF_CA	1044..1075	CDD:214542	20/30 (67%)
		EGF_CA	1085..1125	CDD:214542	24/39 (62%)
		EGF_CA	1126..1167	CDD:214542	23/40 (58%)
		EGF_CA	1168..1209	CDD:214542	29/40 (73%)
		EGF_CA	1210..1243	CDD:214542	21/32 (66%)
		TB	1344..1387	CDD:366245	33/42 (79%)
		TB	1522..1565	CDD:366245	35/42 (83%)
		EGF_CA	1642..>1676	CDD:214542	28/33 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	547	1.000	Domainoid score	I3001
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H522
Inparanoid	1	1.050	2256	1.000	Inparanoid score	I503
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10682at7742
OrthoFinder	1	1.000	-	-		FOG0008834
OrthoInspector	1	1.000	-	-		oto153031
Panther	1	1.100	-	-	LDO	PTHR24034
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9017
SonicParanoid	1	1.000	-	-		X6585
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.190