Protein Alignment alpha-Cat and CTNNAL1

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_003789.1
• Gene: CTNNAL1 / 8727
• HGNCID: 2512
• Length: 734
• Species: Homo sapiens
• Alignment Length: 879
• Identity: 217/879 - (24%)
• Similarity: 363/879 - (41%)
• Gaps: 225/879 - (25%)

  Fly    25 LEIRTMSVEKTLEPLVLQVTTLVNTKGPSKKKKGKSKRASALVAAVEKATENFIQKGEQIAYENP 89
            |||:|.|||:||.|||.|:|||:|.|..:||.....:....:..||..|...|::.||.||.||.
Human    30 LEIKTRSVEQTLLPLVSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENW 94

  Fly    90 DITQEMLTAVDEVKKTGDAMSIAA-------REFSEDPCSSL---KRGNMVRAARNLLSAVTRLL 144
            |:.:|:..|..|.|:.|:  :|||       .....|...::   |.| :::|||.|||:||::|
Human    95 DLKEEINIACIEAKQAGE--TIAALTDITNLNHLESDGQITIFTDKTG-VIKAARLLLSSVTKVL 156

  Fly   145 ILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLR 209
            :|||.|.:..::.|.:.|...:.:|:..:|..|.:....|||....|....:..||.:|||.:.:
Human   157 LLADRVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKK 221

  Fly   210 DDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISD-VAQGKSSQPTD 273
            ..:|||||:|:|.:.|||||||..:|||..:.|..|::.:..::..|::.:.: |...|.:..||
Human   222 AKMAAARAVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGETD 286

  Fly   274 -----IYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERR 333
                 |::|..|....::...|.:..        :|::.|...||.|:.......|:..|..|.|
Human   287 ISSISIFTGIKEFKMNIEALRENLYF--------QSKENLSVTLEVILERMEDFTDSAYTSHEHR 343

  Fly   334 ERIVAECNAVRQALQDLLSEYMSNMSQKDNS--PGLSRAIDQMCRKTRDLRRQLR---------- 386
            |||:......|..||.|:|.::...|:|..|  ..|..:|.::.....:|:::|.
Human   344 ERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADL 408

  Fly   387 -KAVVDHVSDSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGV 450
             |...|||....|:.|         ...||.:.:.|.:...::..|:|||...|:..:|..|...
Human   409 LKYHADHVVLKALKLT---------GVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLE 464

  Fly   451 KMVRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFL 515
            ....:|....:....|:|:||..||:.|:||:|:||:..:.:|||.|       :.|::|
Human   465 ITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQ-------ISDMST----- 517

  Fly   516 AVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVK 580
                  :|.::|..
Human   518 ------LLREINDV--------------------------------------------------- 525

  Fly   581 VLRDQVMMKFDQRVGAAVGALS------NNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSE 639
                     |:.|.|...|.||      ||:|                  ::.::
Human   526 ---------FEGRRGEKYGYLSLPKPMKNNAN------------------LKSLK---------- 553

  Fly   640 DLDTDTEFEPVEDLTLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQ---QV 701
                                              ||            |...|::.|||:   ::
Human   554 ----------------------------------PD------------KPDSEEQAKIAKLGLKL 572

  Fly   702 ELFRREKLTFDSEVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAG 766
            .|...:.   |.|:.||:|..|:|:...::|..:...:..||||.|||||:.|:|:..:..:..|
Human   573 GLLTSDA---DCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQDLIHQLEVFAAEG 634

  Fly   767 TKLDKLTREIAEQCPESSTKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSL 831
            .||....:..::|..:.. |..||..:.::...|||:|..:  |..:||    .:...:|..
Human   635 LKLTSSVQAFSKQLKDDD-KLMLLLEINKLIPLCHQLQTVT--KTSLQN----KVFLKVDKC--- 689

  Fly   832 IQAAKNLMNAVV--LTVKYSYVASTKYTRQGTVS 863
            |...:::|..:|  |::.|..:...:....|.||
Human   690 ITKTRSMMALLVQLLSLCYKLLKKLQMENNGWVS 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	216/878 (25%)
CTNNAL1	NP_003789.1	Vinculin	31..675	CDD:460040	204/821 (25%)