DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Cat and Vinac1

DIOPT Version :9

Sequence 1:	NP_524219.1	Gene:	alpha-Cat / 40517	FlyBaseID:	FBgn0010215	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001357870.1	Gene:	Vinac1 / 668894	MGIID:	3649276	Length:	1413	Species:	Mus musculus

Alignment Length:	880	Identity:	167/880 - (18%)
Similarity:	343/880 - (38%)	Gaps:	172/880 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNTKGPSKKKKGKSKRASALVAAVEK---A 73
            |||.          .|:..::|:.:.|:.:|:..|:.:   .::|:.::|..::|....|:   |
Mouse    10 DFGP----------TIQNRAMEQIITPMTVQLCHLLIS---VERKEVQNKALASLQKVAEQLANA 61

  Fly    74 TENFIQKGEQIAYENPD--ITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNL 136
            :|.|:....::|.::.:  :.:||....:.:..:|..:...|.:....|.|......:|..|:.:
Mouse    62 SEEFVHVASRLAGDSEEKWLREEMKPVAESLILSGRNILRVAEKLHLQPESQRHWEELVATAQQV 126

  Fly   137 LSAVTRLLILADMVDVHLLLKS----LHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAA 197
            |....::|:|.|...|.....:    |..|| .|.:.::.:|....:|::.......|.|..:.|
Mouse   127 LVDTKKVLLLDDAAAVRKTRTAANWCLTCVE-ALEEAEDTTSLRTSLDDLAAALFRLGGLTARWA 190

  Fly   198 KRQQELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRH---PELDLAKVNRDFI-----LKQVC 254
            ..|.          |..||..|......||.|:..::||   |:| :|...|.|.     |:::.
Mouse   191 WDQH----------LGRARHRLGCCVPALLAAAHGHLRHPRDPQL-VASRRRVFALTRQSLEELL 244

  Fly   255 DAVNT-ISDVAQGKSSQPTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISA 318
            ||:.. :..|..|..||...:..|..:|...|:|...|             ..||:..|.:::..
Mouse   245 DALQPGVGVVGTGVLSQNGALARGLCKLRKVLEDPGPG-------------HLLLDAPLAAVVWH 296

  Fly   319 AALMADADCTRDERRERIVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRR 383
            ...:  |.|:..:.|..:|:.|   ||.:|  |...:.::.:  :|||..  .:.:...|..|.|
Mouse   297 CLRL--AACSAPQERMHLVSRC---RQLMQ--LRPGVHSLPR--SSPGTD--CEALRAATDALFR 350

  Fly   384 QLRKAVVDHVSDSFLETTTPLLDLIEAAKSGNEKKVREKSE-----------IFTKHAEKLVEVA 437
            .:|..::..:.|:|.:|.:||..|::||.:.:..:.|..||           .|...|::::.||
Mouse   351 AVRAGLLRQILDTFTDTQSPLETLVQAALATSTIRFRCDSEALAETVQILLDAFHNQAKQMIRVA 415

  Fly   438 NLVCSMSNNEDGVKMVRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYR---QAWEVQVR 499
            :||......:...:.:..|.|.::.|   ||....:.:..|.:.....:..|.:   :||..:..
Mouse   416 HLVWVCCPQQQTGRDLEAAVAGLQRL---VIKVKELFSQSPQTLGLDWSPATLQALLEAWARESE 477

  Fly   500 ILTEAVDDITTIDDFLAVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMD 564
            .|....|.:..|.:||:||...:.:.::...:||:.|.:|:...:...::||::.:..|:...:.
Mouse   478 HLLSCFDVVLNIPEFLSVSIQEMTKHLDLSTIALRSGASREFSRSVAFLRGRATHIVQVMSRYVG 542

  Fly   565 NYEPCIYTKRVLEAVKVLRDQVMMKFDQRVGAAV-GALSNNSNKDVDENDFIDASRLVYDGVREI 628
            .....|:...:...|     |.:.:....:|||. |:.:.:|.:|.|.  |:..::.:....:::
Mouse   543 QDPDPIFRNGMRVVV-----QQLAQSSVTLGAATEGSRAEDSAQDTDV--FLTMAKHLIHAAQQV 600

  Fly   629 RRAVLMNRSSEDLDTDTEFEPVEDLTLETRS--------------------------------RS 661
            |         |.||.....:.:..|.::.:.                                :|
Mouse   601 R---------EGLDGSNHPDILSPLRVQVQRFDMTKGWSYFILPSPQHPTASEIKYQRVPGLWKS 656

  Fly   662 SAHTGDQTVDE--YPDISGIC---------TAREAMRKMTEEDKQKIAQQVELFRREKLTFDS-- 713
            ..:|....|::  |..:.|.|         ...:.:..|...:.|.:.........:..|.|:
Mouse   657 GPNTSLLPVEQLSYTVVPGTCIHGWRFPLPAVSKGVTTMENRNHQVVTLPCTNTPEQNSTVDTVQ 721

  Fly   714 EVAKWDDT-GNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIA 777
            |....::| |.:.:...:.:..:...:.|..|               |::..|.|..::|.|...
Mouse   722 ETQAGEETLGPERMTGLQEVSTLAPSIIDLAR---------------KEVHSANTGSEELLRVSF 771

  Fly   778 EQCPESSTKKDLLAYLQRIA--------LYCHQIQ 804
            :|  ...|::|....:.|..        |:||.::
Mouse   772 QQ--SQGTREDRWGLVARAGDWYPLCQQLFCHNLE 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	151/802 (19%)
Vinac1	NP_001357870.1	Vinculin	15..>610	CDD:366435	136/652 (21%)
Vinac1	NP_001357870.1	Vinculin	<1224..1375	CDD:366435
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910