DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Cat and ctnna2

DIOPT Version :9

Sequence 1:	NP_524219.1	Gene:	alpha-Cat / 40517	FlyBaseID:	FBgn0010215	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_005160129.1	Gene:	ctnna2 / 567500	ZFINID:	ZDB-GENE-060815-3	Length:	905	Species:	Danio rerio

Alignment Length:	905	Identity:	580/905 - (64%)
Similarity:	732/905 - (80%)	Gaps:	19/905 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVEKATENFI 78
            |.||||||:|||||::||:.|||||.||||||||  ||||.||||:||:|..|..:||:||:||:
Zfish     8 ILLKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSSKKKGRSKKAHVLAVSVEQATQNFL 72

  Fly    79 QKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRL 143
            :||||||.::.|:.:|::.||::|:|.||.|.:|:.||::|||||:|||.||||||.||||||||
Zfish    73 EKGEQIAKDSQDLKEELIAAVEDVRKQGDTMRVASSEFADDPCSSVKRGTMVRAARALLSAVTRL 137

  Fly   144 LILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQL 208
            ||||||.||..||..|.|||:.|..:|||:::.:|.:..::||:...:|...||:|||||||||.
Zfish   138 LILADMADVMRLLAHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPQC 202

  Fly   209 RDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQPTD 273
            ||::||||..|||::|||.|||:.::|||::...:.|||::.|||.:|:..||..||..|  |||
Zfish   203 RDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIGGISSSAQATS--PTD 265

  Fly   274 I---YSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRER 335
            .   ::|.|||||||::||..|::||:|:||.|.|..||||||||||.||||||:.||||:||||
Zfish   266 EKHGHAGIGELAAALNEFDNKIILDPLTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRER 330

  Fly   336 IVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLET 400
            ||||||||||||||||||||:|..:|:....|:.|||:|.:|||||||||||||:||:|||||||
Zfish   331 IVAECNAVRQALQDLLSEYMNNTGRKEKGDPLNSAIDKMTKKTRDLRRQLRKAVMDHISDSFLET 395

  Fly   401 TTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQIESLCP 465
            ..|||.|||||||||||:|:|.:::|.:||.||||||||.||:||||:|||:||.||.||:||||
Zfish   396 NVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCP 460

  Fly   466 QVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILEDVNKCV 530
            ||||||..|..||.|||||:||..::..||.|||||||||||||::||||:||||||||||||||
Zfish   461 QVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRILTEAVDDITSVDDFLSVSENHILEDVNKCV 525

  Fly   531 MALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFDQRVG 595
            :|||.||...|..|||||:||::||.:::.|||:||||.:||:||||::|:|.:.||.:|.::|.
Zfish   526 IALQEGDVDTLDRTAGAIRGRAARVVHIINAEMENYEPGVYTERVLESIKLLSETVMPRFAEQVE 590

  Fly   596 AAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTLETRSR 660
            .|:.|||.:..:..:||:|||||||||||||:||:||||.|:.|:|:.|::||. ||  .:.|||
Zfish   591 VAIEALSTSPPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQ-ED--YDARSR 652

  Fly   661 SSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDDTGNDI 725
            :|..|.|..:     |:| .:||..|.::.:|:|.|||:|||.||:||...|:|||||||.||||
Zfish   653 TSIQTEDDQL-----IAG-QSARAIMAQLPQEEKAKIAEQVESFRQEKSKLDAEVAKWDDNGNDI 711

  Fly   726 IFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESSTKKDLL 790
            |.|||.||||||||||||||:||||.:.|||||||||:|||:::|||.|.:|:|||:|:.|:|||
Zfish   712 IVLAKQMCMIMMEMTDFTRGKGPLKNSSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLL 776

  Fly   791 AYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSYVASTK 855
            ||||||||||||:.|.|||||:|||:.||||||||||||||||||||||||||||||.|||||||
Zfish   777 AYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGLDSATSLIQAAKNLMNAVVLTVKASYVASTK 841

  Fly   856 YTR-QGT--VSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQS 912
            |.: .||  |:||:|.|:||||||||||:.|||||.:.:||:|||||..:|:.|||||::
Zfish   842 YQKVYGTAAVNSPVVSWRMKAPEKKPLVKREKPEECQTRVRRGSQKKHISPVQALSEFKA 901

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	506/795 (64%)
ctnna2	XP_005160129.1	Vinculin	82..866	CDD:279395	506/794 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	691	1.000	Domainoid score	I128
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68394
Inparanoid	1	1.050	1061	1.000	Inparanoid score	I244
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	1	1.000	-	-		otm25961
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	1	1.100	-	-	LDO	PTHR18914
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2575
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870