Protein Alignment alpha-Cat and vcla

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001122153.1
• Gene: vcla / 552980
• ZFINID: ZDB-GENE-050506-61
• Length: 1131
• Species: Danio rerio
• Alignment Length: 1158
• Identity: 245/1158 - (21%)
• Similarity: 417/1158 - (36%)
• Gaps: 347/1158 - (29%)

  Fly    29 TMSVEKTLEPLVLQVTTLV--NTKGPSKKKKGKS-KRASALVAAVEKATENFIQKGEQIAYENPD 90
            |.::|..|||:..|::.||  :.:|   :..||: ...::.||||:.|..|.::.|::......|
Zfish     6 TKTIESILEPVAQQISHLVIMHEEG---EVDGKAIPDLTSPVAAVQAAVSNLVRVGKETVQTTED 67

  Fly    91 --ITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLILADMVDVH 153
              :.::|.:|..:|:.....:..||:....||.|...|..::..:|.:||..:.||:..|..:|.
Zfish    68 KIMKRDMPSAFIKVENACAKLVEAAQMLRTDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVR 132

  Fly   154 LLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDDLAAARAM 218
            .:::....:.:.|...:...:.::|:...:..|....::.|...:|||||...:.|..|..:...
Zfish   133 KIIRVCKGILEYLTVAEVVETMEDLITYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVTSMNT 197

  Fly   219 LKKHSTMLLTASKVYV----------------RHPELD--LAKVNR------------------- 246
            :|:...:|::|.|::|                |:...|  .|::|.
Zfish   198 VKELLPVLISAIKIFVTTKCTKSHGVEEALKNRNYTFDKMTAEINEIIRVLQLTSWDEDAWANKK 262

  Fly   247 ----------------------------------DFILKQVCDAVNTISDVAQGKS--------- 268
                                              :..|:|:.|....:.::..||.
Zfish   263 DTEAMKRALALIESKMGQAKGWLRDPNALPGDPGEHALRQILDEAGKVGELCAGKERREILGTAK 327

  Fly   269 ------------------------------SQPTDIYSGAGELAA----ALDDFDEGI------- 292
                                          :|..||..|..|.||    ||.:..:.|
Zfish   328 TLGQMTDQVSDVRARGQGATPMGMQKAQQVAQGLDILVGKVENAARKLEALTNAKQAIAKRIDNA 392

  Fly   293 ---VMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRERIVAECNAV----------- 343
               :.||....|.      ||.:.::::.|..:||. |...:.|:.|:.....:
Zfish   393 QSWLADPNGGPEG------EENIRALLAEAKRIADL-CEDPKERDDILRSIGEIAGLTARLVELR 450

  Fly   344 ---------RQALQDLLSEYMSNMSQKD---------------------------NSPGL----- 367
                     .:||...:...:.|:..|.                           |:||:
Zfish   451 RIGKGDTPEARALAKQIGTALQNLQAKTNRAVANMRPAKAAVTLEGKMEQALRWINNPGVDDHGV 515

  Fly   368 ------------------------------------------------------SRAI-DQMCRK 377
                                                                  :||: ..:...
Zfish   516 GQAAIRGLIAEGRRLASSLPGPYRQELLAKCEQVEQLMMQLADLAARGEGESPQARAVAAHLLEA 580

  Fly   378 TRDLRRQLRKAVVDHVSDSFLETTTPLLDLIEAAKS-----GNEKKVREKSEIFTKHAEKLVEVA 437
            .:||:.::::|:...|||.|.:||||:..|..||.:     ..|:...|::..|..||.:|...|
Zfish   581 IKDLKAKMQEAMTQEVSDVFSDTTTPIKLLAVAATAPLEAPNREEVFEERASNFENHASRLGATA 645

  Fly   438 NLVCSMSN-NEDGVKMVRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRIL 501
            ....::.. |:..|:.::.|......|.|||.:||.||...|.::.|.|:..|.:..|...:..:
Zfish   646 EKAAAVGTANKSTVEGIQAAVKSARDLTPQVTSAARILLKNPGNQAAYEHFDTMKNQWIDNIEKM 710

  Fly   502 TEAVDDITTIDDFLAVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNY 566
            |..||:.......|..||..|.:|::||.:|:.....:.|.|.|.:|..|::||..|.:.|::|.
Zfish   711 TSLVDEAIDTKSLLDASEEAIKKDIDKCRVAMANVQPQMLVAGATSIARRANRVLLVAKREVENS 775

  Fly   567 EPCIYTKRVLEAVKVLRDQVMMKFDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRA 631
            |    ..:..|.||...|::.......|.||.|...|..:..: :..|:|:...:...|.::|.|
Zfish   776 E----DPKFRELVKAASDELGRTISPMVMAAKGVAGNIQDPGL-QKGFLDSGYRILAAVGKVREA 835

  Fly   632 VLMNR-----SSEDLD------------------------------TDTEF----------EPV- 650
            .....     ...|||                              .|.||          ||:
Zfish   836 FQPQELDFPPPPPDLDQLHVNDDQAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEMVSEPMM 900

  Fly   651 ---EDLTLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFD 712
               ..|..|.|..||.       .|.|| .|. .|.||  ::..:|:.:.....:.:..|.|...
Zfish   901 VAARSLHDEARKWSSK-------PEVPD-EGF-EAAEA--EVDIDDEDEFTDNEDDYEPELLLMS 954

  Fly   713 S-----------------EVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAK 760
            |                 |..||...|||||..||.|.::|.||:...||....|..:  |..||
Zfish   955 SNQPVNQPILAAAQSLHQEARKWSSKGNDIIGAAKRMALLMAEMSRLVRGGSGNKRAL--IQCAK 1017

  Fly   761 KISEAGTKLDKLTREIAEQCPESSTKKDLLAYLQRIALYCHQIQITSKVKADV---QNISGELIV 822
            .|::|..::.:|.:|:|:||.:...:.:||...:||.....|::|.|.|||.:   .|||.|
Zfish  1018 DIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISEE--- 1079

  Fly   823 SGLDSATS-LIQAAKNLMNAVVLTVKYSYVASTKYTRQGTVSSPIVVWKMKAP 874
             ..:.||. |:..|:|||.:|..||:.:..||.|..   |.:...:.|..|.|
Zfish  1080 -ESEQATEMLVHNAQNLMQSVKETVREAEAASIKIR---TDAGFTLRWVRKTP 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	245/1158 (21%)
vcla	NP_001122153.1	Vinculin	3..1131	CDD:460040	245/1158 (21%)