Protein Alignment alpha-Cat and Ctnnal1

DIOPT Version :9

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_061231.3
• Gene: Ctnnal1 / 54366
• MGIID: 1859649
• Length: 731
• Species: Mus musculus
• Alignment Length: 877
• Identity: 215/877 - (24%)
• Similarity: 363/877 - (41%)
• Gaps: 219/877 - (24%)

  Fly    25 LEIRTMSVEKTLEPLVLQVTTLVNTKGPSKKKKGKSKRASALVAAVEKATENFIQKGEQIAYENP 89
            |||||.|||:||.|||.|:|||:|.|..:||.....:....:..||..|...|::.||.||.||.
Mouse    29 LEIRTRSVEQTLLPLVSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENW 93

  Fly    90 DITQEMLTAVDEVKKTGDAMS----IAAREF--SEDPCSSL--KRGNMVRAARNLLSAVTRLLIL 146
            |:.:|:..|..|.|:.|:.::    :..|..  |:...:.|  |.| :|:|||.|||:||::|:|
Mouse    94 DLKEEINIACIEAKQAGETIASLTDVTKRSHLESDGQVTILTDKTG-VVQAARLLLSSVTKVLLL 157

  Fly   147 ADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDD 211
            ||.|.:..::.|.:.:...:.:|:..:|..|.:....|||....|.......||.:|||.:.:..
Mouse   158 ADRVVIKQIVTSRNKILATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLTGDRQNDLKDEKKKAR 222

  Fly   212 LAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVA-----QGKS-SQ 270
            :|.|||:|:|.:.|||||||..:|||..:.|..|::.:..::..|:..::::.     .|:: |.
Mouse   223 MAVARAVLEKGTMMLLTASKTCLRHPSCESAHTNKEGVFDRMRVALEKVTEIVTDCRLSGETDSS 287

  Fly   271 PTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRER 335
            ...|::|..||...::...|.:..:        |::.|...||:::.......|:..|..|.|||
Mouse   288 SVSIFTGIKELKVNIEALRENVCFE--------SKENLSAALEAVLEHVEDFTDSAYTSHEHRER 344

  Fly   336 IVAECNAVRQALQDLLSEYMSNMSQKDNSPG---------LSRAIDQMCRK----TRDLRRQLRK 387
            |:...:..|..||.|||.:|...|:|..|..         :|.::|::.|:    ...|...|.|
Mouse   345 ILELSSQARTELQQLLSVWMQTQSRKTKSAAEELELTVLKISHSLDELRRELHCTAMQLAADLLK 409

  Fly   388 AVVDHVSDSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKM 452
            ...|||....|:.|         ...||.:.:.|.:...::..|:|||...|:..:|..|.....
Mouse   410 FHADHVVLKALKVT---------GVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEIT 465

  Fly   453 VRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAV 517
            ..:|....:....|:|:||..||:.|:||:|:||:..:.:|||.|       :.|:.|:
Mouse   466 CIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQ-------MSDMATL------ 517

  Fly   518 SENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVL 582
                                   ||..:...:||....|
Mouse   518 -----------------------LREISDVFEGRRGERC-------------------------- 533

  Fly   583 RDQVMMKFDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEF 647
                                                                             
Mouse   534 ----------------------------------------------------------------- 533

  Fly   648 EPVEDLTLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQ---QVELFRREKL 709
               :.|:|...:::||:......|: ||               .|::.|||:   ::.|...:.
Mouse   534 ---DHLSLPKPTKNSANLKSLKPDK-PD---------------SEEQAKIAKLGLKLGLLSSDA- 578

  Fly   710 TFDSEVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTR 774
              |.|:.||:|..|:|:...::|..:...:..||||.|||||:.|:|:..:..:..|.||....:
Mouse   579 --DCEIEKWEDEENEIVRHGRNMSRMAYSLYLFTRGEGPLKTSQDLIHFLEVFAAEGLKLTSSVQ 641

  Fly   775 EIAEQCPESSTKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSL-----IQA 834
            ..::|..:.. |..||..:.::...|||:|..:|              :.|.|...|     |..
Mouse   642 SFSKQLKDDD-KLMLLLEINKLIPLCHQLQTITK--------------TSLQSKVFLKVDKCITK 691

  Fly   835 AKNLMNAVV--LTVKYSYVASTKYTRQGTVSS 864
            .:::|..||  |::.|..:...:..|.|:.::
Mouse   692 IRSMMTLVVQLLSLCYKLLKKMENNRWGSATN 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	186/815 (23%)
Ctnnal1	NP_061231.3	Vinculin	91..674	CDD:279395	174/750 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..559		7/39 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810