DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Cat and Ctnna3

DIOPT Version :9

Sequence 1:	NP_524219.1	Gene:	alpha-Cat / 40517	FlyBaseID:	FBgn0010215	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	XP_038955205.1	Gene:	Ctnna3 / 361839	RGDID:	1562230	Length:	914	Species:	Rattus norvegicus

Alignment Length:	909	Identity:	462/909 - (50%)
Similarity:	641/909 - (70%)	Gaps:	20/909 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MGTLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVN-TKGPSKKKKGKSKRASALVAAV 70
            :|.::....|.|:.|.::|:|:|.:|||.||||::||||||| .:.||.:|||:||||..|:|:|
  Rat    17 IGNMSAETPITLQMDMQDLQIQTFTVEKLLEPLIIQVTTLVNCPQNPSNRKKGRSKRARVLLASV 81

  Fly    71 EKATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARN 135
            |:||.|.:.|||.||.|...:.:::..|:.||:|...|:..:|..|::|||...||..:|:|||.
  Rat    82 EEATWNLLDKGEMIAKEATVLKEDLEAALQEVRKESKALKGSAERFTDDPCYLPKREAVVQAARA 146

  Fly   136 LLSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQ 200
            ||:|||||||||||.||..||:.:...:.....|||.|::.:|....::.|:....|.:.|.|||
  Rat   147 LLAAVTRLLILADMTDVMCLLQHVSSFQRTFKSLKNVSNKSDLQKTYQKLGKELERLDRFAFKRQ 211

  Fly   201 QELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQ 265
            |:||.|..||::|.|||.||::|.:|.:.....:.|.::...|.::|.:.:::.:|::.||:.:|
  Rat   212 QDLKSPSQRDEIAGARATLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALDVISNASQ 276

  Fly   266 GKSSQPTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRD 330
            |..:.|..:...|..|.:|||:.:..||::|:|.:|:..|..||:|||:|||.|||:||:.||||
  Rat   277 GIQNVPASLEPQAATLGSALDELENLIVLNPLTVTEEDLRPPLEKRLEAIISGAALLADSSCTRD 341

  Fly   331 ERRERIVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSD 395
            ..||||:|||||:||||||||||||||:.:.:.|..|:.||..|.:||||||||||||::||:||
  Rat   342 LHRERIIAECNAIRQALQDLLSEYMSNIGKTERSNTLNTAIVNMSKKTRDLRRQLRKAIIDHISD 406

  Fly   396 SFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQI 460
            |||:||.|||.||||||:|..|::::.:.||.:|..:|:|||||.||||.||||:|:||.||..:
  Rat   407 SFLDTTVPLLVLIEAAKNGQVKEIKDYASIFHEHTGRLMEVANLACSMSTNEDGIKIVRIAANHL 471

  Fly   461 ESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILED 525
            |:||||:||||..|..||.|:|.:..|..|::.||..:.:|||||||||:|||||||||:|||||
  Rat   472 ETLCPQIINAALALASRPKSQVVKNTMEMYKRTWEHYIHVLTEAVDDITSIDDFLAVSESHILED 536

  Fly   526 VNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKF 590
            ||:|::||:..||.:|...||||:||::||.::|..|||:|||..||:.|:..|.:|...|:.:|
  Rat   537 VNRCIIALRDQDADNLDRAAGAIRGRAARVAHIVAGEMDSYEPGAYTEGVMRNVNLLTSIVIPEF 601

  Fly   591 DQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTL 655
            ..:|..|:.|||.|:...:|:|.|:|.|:.:||.:.:||.:|::.|:.|:|      |.|.||..
  Rat   602 VTQVNVALDALSKNALTALDDNQFVDISKKIYDTIHDIRCSVMIIRTPEEL------EDVSDLED 660

  Fly   656 ETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDD 720
            :...||  ||..||..:        |.|..|.::.|.:|:|||:||..|::.|...|:|:..|||
  Rat   661 DHEVRS--HTSTQTEGK--------TDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDD 715

  Fly   721 TGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESST 785
            |.||||.|||.||||||||||||||:||||.|.|||.|||.|||:|:::|.|.|:||.|||:...
  Rat   716 TSNDIIVLAKKMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPPC 780

  Fly   786 KKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSY 850
            |:||||||::|..|.||::|.|:|||::||:.||||||.|||.|||||||||||||||.|||.||
  Rat   781 KQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIVSALDSVTSLIQAAKNLMNAVVQTVKMSY 845

  Fly   851 VASTKYTR-QGTVS--SPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911
            :||||..| |.:..  .|:|:|:||||.||||::.|||||..|.||:||.||..:|:..:|||:
  Rat   846 IASTKIIRIQSSAGPRHPVVMWRMKAPAKKPLIKREKPEETWAVVRRGSAKKKIHPVQVMSEFR 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	400/792 (51%)
Ctnna3	XP_038955205.1	Vinculin	102..875	CDD:395830	399/788 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I11675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820