Protein Alignment alpha-Cat and CTNNA3

DIOPT Version :9

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_016871641.1
• Gene: CTNNA3 / 29119
• HGNCID: 2511
• Length: 970
• Species: Homo sapiens
• Alignment Length: 974
• Identity: 470/974 - (48%)
• Similarity: 650/974 - (66%)
• Gaps: 83/974 - (8%)

  Fly     5 DKMGTLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVN-TKGPSKKKKGKSKRASALVA 68
            :|.|:::....|.|..||::|:::|.:|||.||||::||||||| .:.||.:|||:|||||.|:|
Human     8 EKQGSMSAETPITLNIDPQDLQVQTFTVEKLLEPLIIQVTTLVNCPQNPSSRKKGRSKRASVLLA 72

  Fly    69 AVEKATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAA 133
            :||:||.|.:.|||:||.|...:..|:..:::||:|..:|:.::|..|::|||...||..:|:||
Human    73 SVEEATWNLLDKGEKIAQEATVLKDELTASLEEVRKESEALKVSAERFTDDPCFLPKREAVVQAA 137

  Fly   134 RNLLSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAK 198
            |.||:|||||||||||:||..||:.:...:.....|||.:::.:|....::.|:....|...|.|
Human   138 RALLAAVTRLLILADMIDVMCLLQHVSAFQRTFESLKNVANKSDLQKTYQKLGKELENLDYLAFK 202

  Fly   199 RQQ-----------------------ELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELD 240
            |||                       :||.|..||::|.|||.||::|.:|.:.....:.|.::.
Human   203 RQQVNNSGLNTTFAFSRKNLPTPKASDLKSPNQRDEIAGARASLKENSPLLHSICSACLEHSDVA 267

  Fly   241 LAKVNRDFILKQVCDAVNTISDVAQGKSSQPTDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSR 305
            ..|.::|.:.:::.:|:|.||:.:||..:..|.....|..|.:|||:.:..||::|:|.:|:..|
Human   268 SLKASKDTVCEEIQNALNVISNASQGIQNMTTPPEPQAATLGSALDELENLIVLNPLTVTEEEIR 332

  Fly   306 QLLEERLESIISAAALMADADCTRDERRERIVAECNAVRQALQDLLSEYMSNM------------ 358
            ..||:|||:|||.|||:||:.||||..||||:|||||:||||||||||||:||
Human   333 PSLEKRLEAIISGAALLADSSCTRDLHRERIIAECNAIRQALQDLLSEYMNNMRKLIPCRATRLT 397

  Fly   359 ----------------------------SQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSD 395
                                        .:|:.|..|:.|:|.||:||||||||||||::|||||
Human   398 KTAPQVYLTSGLVDSKSTISLLHHEIKAGKKERSNTLNIALDNMCKKTRDLRRQLRKAIIDHVSD 462

  Fly   396 SFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQI 460
            |||:||.|||.||||||:|.||:::|.:.||.:|..:|||||||.||||.||||:|:|:.||..:
Human   463 SFLDTTVPLLVLIEAAKNGREKEIKEYAAIFHEHTSRLVEVANLACSMSTNEDGIKIVKIAANHL 527

  Fly   461 ESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILED 525
            |:||||:||||..|..||.|:..:..|..|::.||..:.:|||||||||:|||||||||:|||||
Human   528 ETLCPQIINAALALAARPKSQAVKNTMEMYKRTWENHIHVLTEAVDDITSIDDFLAVSESHILED 592

  Fly   526 VNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKF 590
            ||||::||:..||.:|...||||:||::||.::|..|||:|||..||:.|:..|..|...|:.:|
Human   593 VNKCIIALRDQDADNLDRAAGAIRGRAARVAHIVTGEMDSYEPGAYTEGVMRNVNFLTSTVIPEF 657

  Fly   591 DQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTL 655
            ..:|..|:.|||.:|...:|:|.|:|.|:.:||.:.:||.:|:|.|:.|:|      |.|.||..
Human   658 VTQVNVALEALSKSSLNVLDDNQFVDISKKIYDTIHDIRCSVMMIRTPEEL------EDVSDLEE 716

  Fly   656 ETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDD 720
            |...||  ||..||..:        |.|..|.::.|.:|:|||:||..|::.|...|:|:..|||
Human   717 EHEVRS--HTSIQTEGK--------TDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDD 771

  Fly   721 TGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESST 785
            |.||||.|||:||||||||||||||:||||.|.|||.|||.|||:|:::|.|.|:||.|||:.|.
Human   772 TSNDIIVLAKNMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPSC 836

  Fly   786 KKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSY 850
            |:||||||::|..|.||::|.|:|||::||:.||||:|.|||.|||||||||||||||.|||.||
Human   837 KQDLLAYLEQIKFYSHQLKICSQVKAEIQNLGGELIMSALDSVTSLIQAAKNLMNAVVQTVKMSY 901

  Fly   851 VASTKYTRQGTVSS---PIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911
            :||||..|..:.:.   |:|:|:||||.||||::.|||||..|.||:||.||..:|:..:|||:
Human   902 IASTKIIRIQSPAGPRHPVVMWRMKAPAKKPLIKREKPEETCAAVRRGSAKKKIHPLQVMSEFR 965

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	406/855 (47%)
CTNNA3	XP_016871641.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157783
Domainoid	1	1.000	672	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	1	1.100	-	-	O	PTHR18914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720