Protein Alignment alpha-Cat and Vcl

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_006518985.1
• Gene: Vcl / 22330
• MGIID: 98927
• Length: 1134
• Species: Mus musculus
• Alignment Length: 1151
• Identity: 238/1151 - (20%)
• Similarity: 425/1151 - (36%)
• Gaps: 330/1151 - (28%)

  Fly    29 TMSVEKTLEPLVLQVTTLV--NTKGPSKKKKGKS-KRASALVAAVEKATENFIQKGEQIAYENPD 90
            |.::|..|||:..|::.||  :.:|   :..||: ...:|.||||:.|..|.::.|::......|
Mouse     6 TRTIESILEPVAQQISHLVIMHEEG---EVDGKAIPDLTAPVAAVQAAVSNLVRVGKETVQTTED 67

  Fly    91 --ITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLILADMVDVH 153
              :.::|..|..:|:.....:..||:....||.|...|..::..:|.:||..:.||:..|..:|.
Mouse    68 QILKRDMPPAFIKVENACTKLVQAAQMLQSDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVR 132

  Fly   154 LLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDDLAAARAM 218
            .:::....:.:.|...:...:.::|:...:..|....::.|...:|||||...:.|..|..:...
Mouse   133 KIIRVCKGILEYLTVAEVVETMEDLVTYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVNSMNT 197

  Fly   219 LKKHSTMLLTASKVYV-----RHPELDLAKVNRDF------------------------------ 248
            :|:...:|::|.|::|     ::..::.|..||:|
Mouse   198 VKELLPVLISAMKIFVTTKNSKNQGIEEALKNRNFTVEKMSAEINEIIRVLQLTSWDEDAWASKD 262

  Fly   249 -----------------------------------ILKQVCDAVNTISDVAQGK----------- 267
                                               .::|:.|....:.::..||
Mouse   263 TEAMKRALASIDSKLNQAKGWLRDPNASPGDAGEQAIRQILDEAGKVGELCAGKERREILGTCKM 327

  Fly   268 ----SSQPTDIYS-GAGELAAAL---DDFDEGI------------VMDPMTYSEKRSRQLL---- 308
                :.|..|:.: |.|....|:   ....:|:            .::.||.|::...:.:
Mouse   328 LGQMTDQVADLRARGQGASPVAMQKAQQVSQGLDVLTAKVENAARKLEAMTNSKQSIAKKIDAAQ 392

  Fly   309 ------------EERLESIISAAALMADADCTRDERRE---RIVAECNAVRQALQDL-------- 350
                        ||::...::.|..:|:. |...:.|:   |.:.|..|:...|.||
Mouse   393 NWLADPNGGPEGEEQIRGALAEARKIAEL-CDDPKERDDILRSLGEIAALTSKLGDLRRQGKGDS 456

  Fly   351 ---------LSEYMSNMSQKDN---------------------------SP-----GLSRA---- 370
                     ::..:.|:..|.|                           :|     |:.:|
Mouse   457 PEARALAKQVATALQNLQTKTNRAVANSRPAKAAVHLEGKIEQAQRWIDNPTVDDRGVGQAAIRG 521

  Fly   371 --------------------------IDQMCRK-------------------------TRDLRRQ 384
                                      :||:..:                         .:||:.|
Mouse   522 LVAEGHRLANVMMGPYRQDLLAKCDRVDQLTAQLADLAARGEGESPQARALASQLQDSLKDLKAQ 586

  Fly   385 LRKAVVDHVSDSFLETTTPLLDLIEAAKS-----GNEKKVREKSEIFTKHAEKLVEVANLVCSMS 444
            :::|:...|||.|.:||||:..|..||.:     ..|:...|::..|..|:.:|...|....::.
Mouse   587 MQEAMTQEVSDVFSDTTTPIKLLAVAATAPPDAPNREEVFDERAANFENHSGRLGATAEKAAAVG 651

  Fly   445 N-NEDGVKMVRYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDI 508
            . |:..|:.::.:......|.||||:||.||...|.::.|.|:..|.:..|...|..:|..||:.
Mouse   652 TANKSTVEGIQASVKTARELTPQVISAARILLRNPGNQAAYEHFETMKNQWIDNVEKMTGLVDEA 716

  Fly   509 TTIDDFLAVSENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTK 573
            ......|..||..|.:|::||.:|:.....:.|.|.|.:|..|::|:..|.:.|::|.|    ..
Mouse   717 IDTKSLLDASEEAIKKDLDKCKVAMANIQPQMLVAGATSIARRANRILLVAKREVENSE----DP 777

  Fly   574 RVLEAVKVLRDQVMMKFDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRA------- 631
            :..||||...|::.......|..|.....|.|:..: :..|:|:...:...|.::|.|
Mouse   778 KFREAVKAASDELSKTISPMVMDAKAVAGNISDPGL-QKSFLDSGYRILGAVAKVREAFQPQEPD 841

  Fly   632 -------VLMNRSSEDL---------------------DTDTEF----------EPV----EDLT 654
                   :...|.:::|                     :.|.||          :|:    ..|.
Mouse   842 FPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMMAARQLH 906

  Fly   655 LETRSRSS----------------AHTGDQTVDEYP-DISGICTAREAMRKMTEEDKQKIAQQVE 702
            .|.|..||                |:..|.....:| |:.........:....:...|.|....:
Mouse   907 DEARKWSSKPGIPAAQVGIGVVAEANAADAVGFPFPSDMEDDYEPELLLMPSNQPVNQPILAAAQ 971

  Fly   703 LFRREKLTFDSEVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGT 767
            ...|       |..||...|||||..||.|.::|.||:...||....|..:  |..||.|::|..
Mouse   972 SLHR-------EATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGSGTKRAL--IQCAKDIAKASD 1027

  Fly   768 KLDKLTREIAEQCPESSTKKDLLAYLQRIALYCHQIQITSKVKADV---QNISGELIVSGLDSAT 829
            ::.:|.:|:|:||.:...:.:||...:||.....|::|.|.|||.:   .|||.|    ..:.||
Mouse  1028 EVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISDE----ESEQAT 1088

  Fly   830 S-LIQAAKNLMNAVVLTVKYSYVASTKYTRQGTVSSPIVVWKMKAP 874
            . |:..|:|||.:|..||:.:..||.|..   |.:...:.|..|.|
Mouse  1089 EMLVHNAQNLMQSVKETVREAEAASIKIR---TDAGFTLRWVRKTP 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	238/1151 (21%)
Vcl	XP_006518985.1	Vinculin	3..1134	CDD:460040	238/1151 (21%)