DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Cat and Ctnna3

DIOPT Version :9

Sequence 1:	NP_524219.1	Gene:	alpha-Cat / 40517	FlyBaseID:	FBgn0010215	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001157848.1	Gene:	Ctnna3 / 216033	MGIID:	2661445	Length:	895	Species:	Mus musculus

Alignment Length:	900	Identity:	463/900 - (51%)
Similarity:	633/900 - (70%)	Gaps:	20/900 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVN-TKGPSKKKKGKSKRASALVAAVEKATENFIQ 79
            |.|..|.::|:|:|.:|||.||||::||||||| .:.||.:|||:||||..|:|:||:||.|.:.
Mouse     7 ITLNMDTQDLQIQTFTVEKLLEPLIIQVTTLVNCPQNPSNRKKGRSKRARVLLASVEEATWNLLD 71

  Fly    80 KGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLL 144
            |||.||.|...:.:|:..|:.||:|...|:.::|..|::|||...||..:|:|||.||:||||||
Mouse    72 KGEMIAKEATVLKEELAAALQEVRKESKALKVSAERFTDDPCYLPKREAVVQAARALLAAVTRLL 136

  Fly   145 ILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLR 209
            :||||:||..||:.:...:.....|||.|::.:|....::.|:....|...|.||||:||.|..|
Mouse   137 VLADMIDVMCLLQHVSSFQRTFESLKNVSNKSDLQRTYQKLGKELESLDYLAFKRQQDLKSPSQR 201

  Fly   210 DDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQPTDI 274
            |::|.|||.||::|.:|.:.....:.|.::...|.::|.:.:::.:|::.||:.:||..:.|...
Mouse   202 DEIAGARATLKENSPLLHSICSACLEHSDVASLKASKDTVCEEIQNALDVISNASQGIQNAPAPP 266

  Fly   275 YSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRERIVAE 339
            ...|..|.:|.|:.:..||::|:|.:|:..|..||:|||:|||.|||:||:.||||..||||:||
Mouse   267 EPQAATLGSAFDELENLIVLNPLTVTEEDVRPSLEKRLEAIISGAALLADSSCTRDLHRERIIAE 331

  Fly   340 CNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLETTTPL 404
            |||:||||||||:|||||..:.:.|..|:.||..|.:||||||||||||::||:|||||:||.||
Mouse   332 CNAIRQALQDLLTEYMSNTGKTERSNTLNTAIVNMSKKTRDLRRQLRKAIIDHISDSFLDTTVPL 396

  Fly   405 LDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQIESLCPQVIN 469
            |.||||||:|..|::::.:.||.:|..:|||||||.||||.||||:|:||.||..:|:||||:||
Mouse   397 LVLIEAAKNGRVKEIKDYAAIFHEHTGRLVEVANLACSMSTNEDGIKIVRIAANHLETLCPQIIN 461

  Fly   470 AASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILEDVNKCVMALQ 534
            ||..|..||.|:|.:..|..|::.||..:.:|||||||||:|||||||||:|||||||||::||:
Mouse   462 AALALASRPKSQVVKNTMEMYKRTWEHYIHVLTEAVDDITSIDDFLAVSESHILEDVNKCIIALR 526

  Fly   535 VGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFDQRVGAAVG 599
            ..||.:|...||||:||::||.::|..|||:|||..||:.|:..|..|...|:.:|..:|..|:.
Mouse   527 DQDADNLDRAAGAIRGRAARVAHIVAGEMDSYEPGAYTEGVMRNVNFLTSTVIPEFVTQVNVALD 591

  Fly   600 ALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTLETRSRSSAH 664
            |||.||...:|:|.|:|.|:.:||.:.:||.:|:|.|:.|:|      |.|.||..:...||  |
Mouse   592 ALSKNSLTALDDNQFVDISKKIYDTIHDIRCSVMMIRTPEEL------EDVSDLEDDHEVRS--H 648

  Fly   665 TGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDDTGNDIIFLA 729
            |..||..:        |.|..|.::.|.:|:|||:||..|::.|...|:|:..||||.||||.||
Mouse   649 TSIQTEGK--------TDRAKMTQLPEAEKEKIAEQVADFKKVKSKLDAEIEIWDDTSNDIIVLA 705

  Fly   730 KHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESSTKKDLLAYLQ 794
            |.||||||||||||||:||||.|.|||.|||.|||:|:::|.|.|:||.|||:...|:||||||:
Mouse   706 KKMCMIMMEMTDFTRGKGPLKHTTDVIYAAKMISESGSRMDVLARQIANQCPDPPCKQDLLAYLE 770

  Fly   795 RIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSYVASTKYTR- 858
            :|..|.||::|.|:|||::||:.||||||.|||.|||||||||||||||.|||.||:||||..|
Mouse   771 QIKFYSHQLKICSQVKAEIQNLGGELIVSALDSVTSLIQAAKNLMNAVVQTVKMSYIASTKIIRI 835

  Fly   859 QGTVS--SPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911
            |.:..  .|:|:|:||||.||||::.|||||..|.||:||.||..:|:..:|||:
Mouse   836 QSSAGPRHPVVMWRMKAPAKKPLIKREKPEETWAAVRRGSAKKKIHPVQVMSEFR 890

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	402/792 (51%)
Ctnna3	NP_001157848.1	Vinculin	18..856	CDD:366435	439/853 (51%)
Ctnna3	NP_001157848.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	635..660		10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848170
Domainoid	1	1.000	672	1.000	Domainoid score	I149
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	1	1.100	-	-	O	PTHR18914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.720