Protein Alignment alpha-Cat and hmp-1

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001122991.1
• Gene: hmp-1 / 179624
• WormBaseID: WBGene00001978
• Length: 930
• Species: Caenorhabditis elegans
• Alignment Length: 910
• Identity: 377/910 - (41%)
• Similarity: 562/910 - (61%)
• Gaps: 47/910 - (5%)

  Fly    26 EIRTMSVEKTLEPLVLQVTTLVNTKGPSKKKKGKSKRASALVAAVEKATENFIQKGE------QI 84
            |:|:.:|.|.:..|:.:||.:..|   ...|.|::  ...|||.::.|..||:|.|.      .|
 Worm    15 EVRSKNVLKQITQLINEVTNITET---FPLKPGQT--TEGLVATLDAAVANFLQTGSFAISKCPI 74

  Fly    85 AYENP---DITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRLLIL 146
            |..:|   |:..|.|.||.:   ||..|....|:|..|..|:.||.....:.||||:||.:.|||
 Worm    75 ANSDPRAIDLLHEALGAVQD---TGQVMIQTGRDFVRDSTSTNKRAIATNSGRNLLTAVAKFLIL 136

  Fly   147 ADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQLRDD 211
            ||.:||.:::..:..|.:..:::..|.::.::.|..........||.....:|..:|..|..|||
 Worm   137 ADSIDVKVIVDKVDEVRETAHQMIEADTKIKVDDLYNLLISQIEELDITVRRRAIDLVKPNQRDD 201

  Fly   212 LAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQPT-DIY 275
            |.|||:.|::.:.:|.|:::.:|||||.:.|:.|||:...::..|:|.:..|..|:..:.| ..|
 Worm   202 LLAARSALRQTAPLLYTSTRTFVRHPEHEEARRNRDYTADEMHSALNALESVLNGQQPKVTFSEY 266

  Fly   276 SGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRERIVAEC 340
            ...|:|...:|.|...|.:||..|.....|..||...|.|:|.:|.:|||:.||:.|:::|||||
 Worm   267 GRIGDLINEIDTFQNRIEIDPAHYRRGTDRPDLEGHCERIVSGSASIADAESTRENRKQKIVAEC 331

  Fly   341 NAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLETTTPLL 405
            |.:|||||:||:||..:..::|::..:...|.::.::|:||||.||:|:|||:||:||:|.|||:
 Worm   332 NNLRQALQELLTEYEKSTGRRDDNDDIPLGIAEVHKRTKDLRRHLRRAIVDHISDAFLDTRTPLI 396

  Fly   406 DLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQIESLCPQVINA 470
            .||||||.|:|:..|.:|::|.:||.::|.||.|.|.:|::.:.|.::::.|||:|.|.|||..|
 Worm   397 LLIEAAKEGHEENTRYRSKMFQEHANEIVSVARLSCQLSSDVESVSVIQHTAAQLEKLAPQVAQA 461

  Fly   471 ASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILEDVNKCVMAL-- 533
            |.:|..:|.||.|||||.||:.||..:||:||.|:|:|||:||||||||.||:||..:.:..:
 Worm   462 AILLCHQPTSKTAQENMETYKNAWFDKVRLLTTALDNITTLDDFLAVSEAHIVEDCERGIKGITA 526

  Fly   534 -------QVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFD 591
                   ...:...:...||:|:||:.|||:||:||||..:...||:.|.:||::|:.|.:.:|.
 Worm   527 NASTPDENAANCETVDCAAGSIRGRALRVCDVVDAEMDFLQNSEYTETVKQAVRILKTQRVDQFA 591

  Fly   592 QRVGA------AVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPV 650
            :|..|      |.|...:...|:.:.|:||:|..||:|.|::||.|:|||||..|:|:|.|:|
 Worm   592 ERASALANRQEAHGLTWDPKTKEEEMNEFINACTLVHDAVKDIRHALLMNRSMNDVDSDVEYE-- 654

  Fly   651 EDLTLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEV 715
                       :...|....|....||.....:..||::.||:|:||..|:::|:..:..|:.||
 Worm   655 -----------ADGVGAANADANRTISEQENQQNLMRRLPEEEKKKIQAQIDIFKVTQTRFEREV 708

  Fly   716 AKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQC 780
            ||||:||||||.||.:||.|||.||:||||.||||||||||.||::||..|:||:.|.|:|.|:.
 Worm   709 AKWDETGNDIISLANNMCKIMMSMTEFTRGCGPLKTTMDVIRAAQEISLNGSKLNALARQIGEES 773

  Fly   781 PESSTKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLT 845
            .:|.|||||||||.:|.|||.|:.|.|||||||..:..||:||.||||.||||.|:||:.|||.|
 Worm   774 ADSQTKKDLLAYLSQITLYCQQLNICSKVKADVTQVGNELVVSALDSAMSLIQTARNLLTAVVQT 838

  Fly   846 VKYSYVASTKYTRQGTVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEF 910
            ||.:|:||||: |:...:|..|.|:|..|:|:||:||:|...:....|:.|:::...|...|:||
 Worm   839 VKAAYIASTKF-RRPNANSVRVEWRMAPPKKQPLIRPQKNNAIIRVCRRASERRPLQPAKVLAEF 902

  Fly   911  910
             Worm   903  902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	365/875 (42%)
hmp-1	NP_001122991.1	Vinculin	15..869	CDD:460040	365/875 (42%)