Protein Alignment alpha-Cat and CTNNA2

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001269526.1
• Gene: CTNNA2 / 1496
• HGNCID: 2510
• Length: 953
• Species: Homo sapiens
• Alignment Length: 953
• Identity: 582/953 - (61%)
• Similarity: 732/953 - (76%)
• Gaps: 67/953 - (7%)

  Fly    16 IALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVEKATENFI 78
            |.||||||:|||||::||:.|||||.||||||||  ||||.||||:||:|..|.|:||:||:||:
Human     8 IILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFL 72

  Fly    79 QKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRL 143
            :||||||.|:.|:.:|::.||::|:|.|:.|.||:.||::|||||:|||.||||||.||||||||
Human    73 EKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRL 137

  Fly   144 LILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQL 208
            ||||||.||..||..|.|||:.|..:|||:::.:|.:..::||:...:|...||:||||||||..
Human   138 LILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHC 202

  Fly   209 RDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQPTD 273
            ||::||||..|||::|||.|||:.::|||::...:.|||::.|||.:|:..||:.||..|  |||
Human   203 RDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQATS--PTD 265

  Fly   274 I---YSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRER 335
            .   ::|.|||||||::||..|::||||:||.|.|..||||||||||.||||||:.||||:||||
Human   266 EAKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRER 330

  Fly   336 IVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLET 400
            ||||||||||||||||||||:|..:|:....|:.|||:|.:|||||||||||||:||:|||||||
Human   331 IVAECNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLET 395

  Fly   401 TTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQIESLCP 465
            ..|||.|||||||||||:|:|.:::|.:||.||||||||.||:||||:|||:||.||.||:||||
Human   396 NVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCP 460

  Fly   466 QVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILEDVNKCV 530
            ||||||..|..||.|||||:||..::..||.|||:|||||||||::||||:||||||||||||||
Human   461 QVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCV 525

  Fly   531 MALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFDQRVG 595
            :|||.||...|..|||||:||::||.:::.|||:|||..:||::||||.|:|.:.||.:|.::|.
Human   526 IALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVE 590

  Fly   596 AAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTLETRSR 660
            .|:.|||.|..:..:||:|||||||||||||:||:||||.|:.|:|:.|::||. ||  .:.|||
Human   591 VAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQ-ED--YDVRSR 652

  Fly   661 SSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDDTGNDI 725
            :|..|.|..:     |:| .:||..|.::.:|:|.|||:|||:|.:||...|:|||||||:||||
Human   653 TSVQTEDDQL-----IAG-QSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDI 711

  Fly   726 IFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESSTKKDLL 790
            |.|||.||||||||||||||:||||.|.|||||||||:|||:::|||.|.:|:|||:|:.|:|||
Human   712 IVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLL 776

  Fly   791 AYLQRIALYCHQIQITSKVKADVQNISGELIVSG------------------------------- 824
            ||||||||||||:.|.|||||:|||:.|||||||
Human   777 AYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLP 841

  Fly   825 -----------------LDSATSLIQAAKNLMNAVVLTVKYSYVASTKYTR-QGT--VSSPIVVW 869
                             |||||||||||||||||||||||.||||||||.: .||  |:||:|.|
Human   842 TCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSW 906

  Fly   870 KMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQS 912
            |||||||||||:.|||||.:.:||:|||||..:|:.|||||::
Human   907 KMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKA 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	551/906 (61%)
CTNNA2	NP_001269526.1	Vinculin	18..914	CDD:460040	551/906 (61%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	912..939		18/26 (69%)