DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Cat and CTNNA1

DIOPT Version :9

Sequence 1:	NP_524219.1	Gene:	alpha-Cat / 40517	FlyBaseID:	FBgn0010215	Length:	917	Species:	Drosophila melanogaster
Sequence 2:	NP_001310911.1	Gene:	CTNNA1 / 1495	HGNCID:	2509	Length:	906	Species:	Homo sapiens

Alignment Length:	911	Identity:	562/911 - (61%)
Similarity:	716/911 - (78%)	Gaps:	17/911 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVE 71
            |....|.|..|||||:|||||::||:.|||||.||||||||  ||||.||:|:||:|..|.|:||
Human     2 TAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVE 66

  Fly    72 KATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNL 136
            :|||||::||::||.|:..:.:|::.||::|:|.||.|..||.||::|||||:||||||||||.|
Human    67 QATENFLEKGDKIAKESQFLKEELVAAVEDVRKQGDLMKAAAGEFADDPCSSVKRGNMVRAARAL 131

  Fly   137 LSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQ 201
            |||||||||||||.||:.||..|.:|||.:.||:||.::.:|....:.......:|...||||||
Human   132 LSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQ 196

  Fly   202 ELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQG 266
            ||||...||.:||||.:|:|:..:|.|||:..::||::...|.|||.|.||:..||..||:.||.
Human   197 ELKDVGHRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQA 261

  Fly   267 KSSQPTDIY--SGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTR 329
            .:|.....:  .|.||||.||::||:.|::||:::||:|.|..||||||||||.||||||:.|||
Human   262 TASDDASQHQGGGGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTR 326

  Fly   330 DERRERIVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVS 394
            |:||||||||||||||||||||||||.|..:|:.|..|:.|||:|.:|||||||||||||:||||
Human   327 DDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVS 391

  Fly   395 DSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQ 459
            ||||||..|||.||||||:||||:|:|.:::|.:||.||:|||||.||:||||:|||:||.:|:|
Human   392 DSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQ 456

  Fly   460 IESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILE 524
            :|:|||||||||..|..:|.||:|||||..:::.||.|||:||:||||||:||||||||||||||
Human   457 LEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILE 521

  Fly   525 DVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMK 589
            ||||||:|||..|...|..|||||:||::||.:||.:|||||||.:||::||||.|:|.:.||.:
Human   522 DVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPR 586

  Fly   590 FDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLT 654
            |.::|.|||.|||::..:.:|||:|||||||||||:|:||:||||.|:.|:|| |::|| .||
Human   587 FTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELD-DSDFE-TED-- 647

  Fly   655 LETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWD 719
            .:.|||:|..|.|..:     |:| .:||..|.::.:|.|.|||:||..|:.||...|:||:|||
Human   648 FDVRSRTSVQTEDDQL-----IAG-QSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWD 706

  Fly   720 DTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESS 784
            |:|||||.|||.||||||||||||||:||||.|.|||:|||||:|||:::|||.|.||:.||:|:
Human   707 DSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSA 771

  Fly   785 TKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYS 849
            .|:|||||||||||||||:.|.|||||:|||:.|||:|||:|||.||||||||||||||.|||.|
Human   772 CKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKAS 836

  Fly   850 YVASTKYTR-QG--TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911
            |||||||.: ||  :::.|.|.||||||||||||:.||.:|.:.|:::.||||..||:.|||||:
Human   837 YVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFK 901

  Fly   912 S 912
            :
Human   902 A 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	491/794 (62%)
CTNNA1	NP_001310911.1	Involved in homodimerization	2..228		129/225 (57%)
		Vinculin	82..867	CDD:395830	491/794 (62%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000269\|PubMed:9152027	97..148		39/50 (78%)
		Interaction with alpha-actinin	325..394		53/68 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..894		16/29 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	672	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_KOG3681
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1087	1.000	Inparanoid score	I241
Isobase	1	0.950	-	0	Normalized mean entropy	S3027
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	1	1.000	-	-		otm42067
orthoMCL	1	0.900	-	-		OOG6_103558
Panther	1	1.100	-	-	O	PTHR18914
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.790