Protein Alignment alpha-Cat and Ctnna1

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_033948.1
• Gene: Ctnna1 / 12385
• MGIID: 88274
• Length: 906
• Species: Mus musculus
• Alignment Length: 911
• Identity: 562/911 - (61%)
• Similarity: 716/911 - (78%)
• Gaps: 17/911 - (1%)

  Fly     9 TLTDFGQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVE 71
            |....|.|..|||||:|||||::||:.|||||.||||||||  ||||.||:|:||:|..|.|:||
Mouse     2 TAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVE 66

  Fly    72 KATENFIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNL 136
            :|||||::||::||.|:..:.:|::.||::|:|.||.|..||.||::|||||:||||||||||.|
Mouse    67 QATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARAL 131

  Fly   137 LSAVTRLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQ 201
            |||||||||||||.||:.||..|.:|||.:.||:||.::.:|....:.......:|...||||||
Mouse   132 LSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQ 196

  Fly   202 ELKDPQLRDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQG 266
            ||||...||.:||||.:|:|:..:|.|||:..::||::...|.|||.|.||:..||..||:.||.
Mouse   197 ELKDVGNRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQA 261

  Fly   267 KSSQPTDIYSG--AGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTR 329
            .:|.....:.|  .||||.||::||:.|::||:::||:|.|..||||||||||.||||||:.|||
Mouse   262 TASDDAAQHQGGSGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTR 326

  Fly   330 DERRERIVAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVS 394
            |:||||||||||||||||||||||||.|..:|:.|..|:.|||:|.:|||||||||||||:||||
Mouse   327 DDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVS 391

  Fly   395 DSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQ 459
            ||||||..|||.||||||:||||:|:|.:::|.:||.||:|||||.||:||||:|||:||.:|:|
Mouse   392 DSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQ 456

  Fly   460 IESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILE 524
            :|:|||||||||..|..:|.||:|||||..:::.||.|||:||:||||||:||||||||||||||
Mouse   457 LEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILE 521

  Fly   525 DVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMK 589
            ||||||:|||..|...|..|||||:||::||.:||.:|||||||.:||::||||.|:|.:.||.:
Mouse   522 DVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPR 586

  Fly   590 FDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLT 654
            |.::|.|||.|||::..:.:|||:|||||||||||:|:||:||||.|:.|:|| |::|| .||
Mouse   587 FTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELD-DSDFE-TED-- 647

  Fly   655 LETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWD 719
            .:.|||:|..|.|..:     |:| .:||..|.::.:|.|.|||:||..|:.||...|:||:|||
Mouse   648 FDVRSRTSVQTEDDQL-----IAG-QSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWD 706

  Fly   720 DTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESS 784
            |:|||||.|||.||||||||||||||:||||.|.|||:|||||:|||:::|||.|.||:.||:|:
Mouse   707 DSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSA 771

  Fly   785 TKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYS 849
            .|:|||||||||||||||:.|.|||||:|||:.|||:|||:|||.||||||||||||||.|||.|
Mouse   772 CKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKAS 836

  Fly   850 YVASTKYTR-QG--TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQ 911
            |||||||.: ||  :::.|.|.||||||||||||:.||.:|.:.|:::.||||..||:.|||||:
Mouse   837 YVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFK 901

  Fly   912 S 912
            :
Mouse   902 A 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	533/857 (62%)
Ctnna1	NP_033948.1	Involved in homodimerization. /evidence=ECO:0000250	2..228		129/225 (57%)
		Vinculin	19..867	CDD:460040	533/857 (62%)
		Interaction with JUP and CTNNB1. /evidence=ECO:0000250	97..148		39/50 (78%)
		Interaction with alpha-actinin. /evidence=ECO:0000250	325..394		53/68 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	864..894		16/29 (55%)