Protein Alignment alpha-Cat and ctnna1

DIOPT Version :10

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: XP_002932348.2
• Gene: ctnna1 / 100493479
• XenbaseID: XB-GENE-479599
• Length: 903
• Species: Xenopus tropicalis
• Alignment Length: 904
• Identity: 557/904 - (61%)
• Similarity: 710/904 - (78%)
• Gaps: 15/904 - (1%)

  Fly    14 GQIALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVEKATEN 76
            |.|..|||||:|||||::||:.|||||.|||||||:  ||||.||||:||:|..|.|:||:||:|
 Frog     6 GNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNSSNKGPSNKKKGRSKKAHVLAASVEQATQN 70

  Fly    77 FIQKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVT 141
            |:.||::||.|:..:.:|::.||::|:|.|:.|..|:.||::|||||:||||||||||.||||||
 Frog    71 FLDKGDKIAKESQFLKEELIAAVEDVRKQGEQMRSASGEFADDPCSSVKRGNMVRAARALLSAVT 135

  Fly   142 RLLILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDP 206
            ||||||||.||:.||..|.:||:.:.||:||.::.:|....:.......:|....|||||||||.
 Frog   136 RLLILADMADVYRLLVQLKVVEEGIVKLRNAGTEQDLGIQYKALKAEVDKLNVMTAKRQQELKDI 200

  Fly   207 QLRDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQP 271
            ..||.:||||.:|:|...:|.|||:..::||::...|.|||.|.||:..||..||:.||..||:.
 Frog   201 GHRDQMAAARGILQKSIPILYTASQACLQHPDVAAFKANRDLIYKQLQQAVTGISNAAQATSSEE 265

  Fly   272 TDIYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRERI 336
            |....|.||||.||::||:.|::||:.:||:|.|..||||||||||.||||||:.||||:|||||
 Frog   266 TAHQQGGGELAVALNNFDKQIIVDPLGFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERI 330

  Fly   337 VAECNAVRQALQDLLSEYMSNMSQKDNSPGLSRAIDQMCRKTRDLRRQLRKAVVDHVSDSFLETT 401
            |||||:|||||||||||||.|..:|:.|..|:.|||:|.||||||||||||||:||||||||||.
 Frog   331 VAECNSVRQALQDLLSEYMGNTGRKERSDALNSAIDKMTRKTRDLRRQLRKAVMDHVSDSFLETN 395

  Fly   402 TPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMVRYAAAQIESLCPQ 466
            .|||.||||||:||||:|:|.:::|.:||.||:|||||.||:||||:|||:||.:|..:||:|||
 Frog   396 VPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRISAGHLESMCPQ 460

  Fly   467 VINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVSENHILEDVNKCVM 531
            |||||..|..:|:||:|||.|..:::.||.|||:||:||||||:||||||||||||||||||||:
 Frog   461 VINAALALAAKPHSKMAQETMDLFKEQWERQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVI 525

  Fly   532 ALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLRDQVMMKFDQRVGA 596
            |||..|...|..|||||:||::||.:||.:|||||||.:||::||||.|:|.:.||.:|.::|.|
 Frog   526 ALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEA 590

  Fly   597 AVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFEPVEDLTLETRSRS 661
            ||.|||.::|:.:|||:|||||||||||:|:||:||||.|:.|:|| |::|| .||  .:.|||:
 Frog   591 AVEALSGDTNQTMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELD-DSDFE-TED--FDVRSRT 651

  Fly   662 SAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDSEVAKWDDTGNDII 726
            |..|.|..:     |:| .:||..|.::.:|.|.|||:||..|:.||...|:||:||||.|||||
 Frog   652 SVQTEDDQL-----IAG-QSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDNGNDII 710

  Fly   727 FLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAEQCPESSTKKDLLA 791
            .|||.||||||||||||||:||||.|.|||:|||||:|||:::|||.|.||:.||:|:.|:||||
 Frog   711 VLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLA 775

  Fly   792 YLQRIALYCHQIQITSKVKADVQNISGELIVSGLDSATSLIQAAKNLMNAVVLTVKYSYVASTKY 856
            |||||||||||:.|.|||||:|||:.|||:|||:|||.||||||||||||||.|||.||||||||
 Frog   776 YLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKY 840

  Fly   857 TR-QG--TVSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQS 912
            .: ||  :::.|.|.||||||||||||:.||.:|.:.|:::.||||..||:.|||||::
 Frog   841 QKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKA 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	26..877	CDD:460040	529/855 (62%)
ctnna1	XP_002932348.2	Vinculin	18..864	CDD:460040	529/855 (62%)