Protein Alignment alpha-Cat and ctnna2

DIOPT Version :9

• Sequence 1: NP_524219.1
• Gene: alpha-Cat / 40517
• FlyBaseID: FBgn0010215
• Length: 917
• Species: Drosophila melanogaster
• Sequence 2: NP_001090774.1
• Gene: ctnna2 / 100037860
• XenbaseID: XB-GENE-5955201
• Length: 966
• Species: Xenopus tropicalis
• Alignment Length: 966
• Identity: 575/966 - (59%)
• Similarity: 730/966 - (75%)
• Gaps: 80/966 - (8%)

  Fly    16 IALKWDPKNLEIRTMSVEKTLEPLVLQVTTLVNT--KGPSKKKKGKSKRASALVAAVEKATENFI 78
            |.||||||:|||||::||..|||||.||||||||  ||||.||||:||:|..|.|:||:||:||:
 Frog     8 IILKWDPKSLEIRTLTVESLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFL 72

  Fly    79 QKGEQIAYENPDITQEMLTAVDEVKKTGDAMSIAAREFSEDPCSSLKRGNMVRAARNLLSAVTRL 143
            :||||||.|:.|:.:|:::||::|:|.||.|.|.:.||::|||||:|||.||||||.||||||||
 Frog    73 EKGEQIAKESQDLKEELISAVEDVRKQGDTMRITSSEFADDPCSSVKRGTMVRAARALLSAVTRL 137

  Fly   144 LILADMVDVHLLLKSLHIVEDDLNKLKNASSQDELMDNMRQFGRNAGELIKQAAKRQQELKDPQL 208
            ||||||.||..||..|.|||:.|..:|||:::.:|....::||:...:|...||:||||||||..
 Frog   138 LILADMADVMRLLIHLKIVEEALESVKNATNEQDLAHRFKEFGKEMVKLNYVAARRQQELKDPHC 202

  Fly   209 RDDLAAARAMLKKHSTMLLTASKVYVRHPELDLAKVNRDFILKQVCDAVNTISDVAQGKSSQPTD 273
            ||::||||..|||::|||.|||:.::|||::...:.|||::.|||.:|:..|::.||..|  |||
 Frog   203 RDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGIANAAQATS--PTD 265

  Fly   274 ---IYSGAGELAAALDDFDEGIVMDPMTYSEKRSRQLLEERLESIISAAALMADADCTRDERRER 335
               .::|.|||||||::||..|::||:|:||.|.|..|||:||||||.||||||:.||||:||||
 Frog   266 EKQAHTGIGELAAALNEFDNKIILDPLTFSEARFRPSLEEKLESIISGAALMADSSCTRDDRRER 330

  Fly   336 IVAECNAVRQALQDLLSEYMSN------------MSQKDNSPGLSRAIDQMCRKTRDLRRQLRKA 388
            ||||||:|||||||||||||:|            ..:|:....|:.|||:|.:||||||||||||
 Frog   331 IVAECNSVRQALQDLLSEYMNNCRYGTWMDESCKSGRKEKGDPLNIAIDKMTKKTRDLRRQLRKA 395

  Fly   389 VVDHVSDSFLETTTPLLDLIEAAKSGNEKKVREKSEIFTKHAEKLVEVANLVCSMSNNEDGVKMV 453
            |:||:|||||||..|||.||||||:||||:|:|.:::|.:||.||||||||.||:||||:|||:|
 Frog   396 VMDHISDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLV 460

  Fly   454 RYAAAQIESLCPQVINAASILTVRPNSKVAQENMTTYRQAWEVQVRILTEAVDDITTIDDFLAVS 518
            |.||.||:||||||||||..|..||.|||||:||..::..||.|||:|||||||||::||||:||
 Frog   461 RMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVS 525

  Fly   519 ENHILEDVNKCVMALQVGDARDLRATAGAIQGRSSRVCNVVEAEMDNYEPCIYTKRVLEAVKVLR 583
            ||||||||||||:|||.||...|..|||||:||::||.:::.|||:|||..:||::||:|.|:|.
 Frog   526 ENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLDATKLLC 590

  Fly   584 DQVMMKFDQRVGAAVGALSNNSNKDVDENDFIDASRLVYDGVREIRRAVLMNRSSEDLDTDTEFE 648
            :.||.:|.::|..|:.|||.|..:..:||:|||||||||||||:||:||||.|:.|:|:.|::||
 Frog   591 ETVMPRFAEQVEFAIEALSANIPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFE 655

  Fly   649 PVEDLTLETRSRSSAHTGDQTVDEYPDISGICTAREAMRKMTEEDKQKIAQQVELFRREKLTFDS 713
            . ||  .:.|||:|..|.|..:     |:| .:||..|.::.:|:|.|||:|||:|.:||...|:
 Frog   656 Q-ED--YDVRSRTSVQTEDDQL-----IAG-QSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDA 711

  Fly   714 EVAKWDDTGNDIIFLAKHMCMIMMEMTDFTRGRGPLKTTMDVINAAKKISEAGTKLDKLTREIAE 778
            |||||||:|||||.|||.||||||||||||||:||||.|.|||||||||:|||:::|||.|.:|:
 Frog   712 EVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVAD 776

  Fly   779 QCPESSTKKDLLAYLQRIALYCHQIQITSKVKADVQNISGELIVSG------------------- 824
            |||:|:.|:||:||||||||||||:.|.|||||:|||:.|||||||
 Frog   777 QCPDSACKQDLIAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTAVQSTFTTFYEVAGDVIA 841

  Fly   825 ------------------------------LDSATSLIQAAKNLMNAVVLTVKYSYVASTKYTR- 858
                                          |||||||||||||||||||||||.||||||||.:
 Frog   842 GGRDSQLSLDLLPSCTEGSLFGSGSRDSTMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKV 906

  Fly   859 QGT--VSSPIVVWKMKAPEKKPLVRPEKPEEVRAKVRKGSQKKVQNPIHALSEFQS 912
            .||  |:||:|.||||||||||||:.|||||.:.:||:|||||..:|:.|||||::
 Frog   907 YGTAAVNSPVVSWKMKAPEKKPLVKREKPEEYQTRVRRGSQKKHISPVQALSEFKA 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Cat	NP_524219.1	Vinculin	87..877	CDD:395830	500/856 (58%)
ctnna2	NP_001090774.1	Vinculin	81..927	CDD:279395	500/856 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	924..952		19/27 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	653	1.000	Domainoid score	I156
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68394
Inparanoid	1	1.050	1069	1.000	Inparanoid score	I251
OMA	1	1.010	-	-		QHG56187
OrthoDB	1	1.010	-	-		D405587at33208
OrthoFinder	1	1.000	-	-		FOG0002407
OrthoInspector	1	1.000	-	-		otm49298
Panther	1	1.100	-	-	LDO	PTHR18914
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2575
SonicParanoid	1	1.000	-	-		X1596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110