DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and Psg21

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_081679.2	Gene:	Psg21 / 72242	MGIID:	1891353	Length:	471	Species:	Mus musculus

Alignment Length:	431	Identity:	91/431 - (21%)
Similarity:	160/431 - (37%)	Gaps:	109/431 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 SWFRG--TKRLT------TYS-----PTHDLVDGLYTSTLELDWTLSREDLAQDI--------EC 242
            :|:||  ..|||      .||     |.|...:.||::.......:::||....|        |.
Mouse    65 AWYRGLINWRLTIALHFLDYSTSMTGPEHSDREILYSNGSLWIQNVTQEDTGYYIFQTISNHGEL 129

  Fly   243 RVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNL-TWYNTTTI 306
            ...::....|..:.|:......|..:.|..|.....:|.:|:|.  :|.....:.| .||....:
Mouse   130 ESNTSTFLQVYSSHFTCGRPSFPAKLTIESVPPRVAEGGRVLLR--VHNLPEYLQLFFWYKGVIM 192

  Fly   307 ISSGENEITEVRSKSLEK-SD-GTFHTQSELIF--------NAT-------RFENDRVFR-CEAE 353
            |    :::..||.::|:. || |..|:..|::|        |.|       ..:....|| .|..
Mouse   193 I----HKVEIVRHRTLKNLSDPGPAHSGREIVFSNGSLLLQNVTWKDTGFYTLQTVNGFREMELA 253

  Fly   354 NIVLQINRE--KPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQVEWYRND 416
            :|.||:...  .|:.||         .:::.|....|...|.|||.....  |..|....||:
Mouse   254 HIYLQVETPCCDPLDSA---------QLRIDPVTPHAAEGESVLLQVHNL--PEDLQTFSWYK-- 305

  Fly   417 ILVNVNDTTHYK------------GGNS--------ENVALVIKSTEKEDIGNYS-CQLSNNIGK 460
               .|:.|..::            .|::        .|.:|:::...::|.|.|: ..:.:|:..
Mouse   306 ---GVDSTPSFQIVEYSKAMKSIISGSAYSRREIGYTNGSLLLQDVTEKDSGLYTLVTIDSNMRV 367

  Fly   461 GTSDQKINLDVQYAPTVEILMIPEGPVKESD---ESNVTLFCNVLDANPSVLTKVRWYANSTLLK 522
            .|...::|:       .:::..|...|.:|.   :|:|...|  ...|..|  .:||..|:..|:
Mouse   368 ETVHVQVNI-------YKLVTQPAMRVTDSTVRVQSSVVFTC--FSDNTGV--SIRWLFNNQSLQ 421

  Fly   523 ELPDCEETREDLCHIDPSK--LLLESIGRGFFYNYSCEGFN 561
                    ..:...:.|||  |.:.::.:.....|.||.||
Mouse   422 --------LTERMTLSPSKCQLRIHTVRKEDAGEYQCEAFN 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	16/69 (23%)
		Ig	277..354	CDD:299845	22/95 (23%)
		IG_like	383..463	CDD:214653	19/100 (19%)
		Ig	394..463	CDD:143165	16/89 (18%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Psg21	NP_081679.2	Ig_CEACAM_D1	36..139	CDD:143251	16/73 (22%)
		IG_like	39..139	CDD:214653	16/73 (22%)
		Ig_CEACAM_D1	155..259	CDD:143251	26/109 (24%)
		Ig_CEACAM_D1	272..374	CDD:143251	20/108 (19%)
		IG_like	276..374	CDD:214653	20/104 (19%)
		IG_like	391..468	CDD:214653	18/76 (24%)
		IGc2	396..457	CDD:197706	18/71 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000