DRSC/TRiP Functional Genomics Resources

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Protein Alignment nrm and nphs1

DIOPT Version :9

Sequence 1:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster
Sequence 2:NP_001035777.1 Gene:nphs1 / 692352 ZFINID:ZDB-GENE-051102-1 Length:1242 Species:Danio rerio


Alignment Length:910 Identity:208/910 - (22%)
Similarity:345/910 - (37%) Gaps:192/910 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   158 VVILDAKGDRIKNGSVVGPMQERQSLKA---TCTVRN----------TRPQPEVSW--------- 200
            ::::|.||       |.|    :|:.|.   ..|||.          .|....|.|         
Zfish    15 LLLVDFKG-------VCG----QQAFKTEPRNVTVRAGATALLKCEVLRASGAVQWVKDGLLLRP 68

  Fly   201 FRGTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRV-KSAAIQNVTVTKFSVDLQVR 264
            .|.......||.|.|...|.|...: ||.||..:.   ..||:| :|.:.:.:......:::|: 
Zfish    69 LRSLPGYPRYSMTGDQKKGQYHLQI-LDVTLEDDG---PYECQVGRSESSRPIVSRTVWLNVQI- 128

  Fly   265 PTSIDINGVKHHT--VQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKS-D 326
            |:|.....::...  |:|.:..:||....|:|...:      ||...|| |:.|..|.::..| |
Zfish   129 PSSQPYFQLESEEPWVEGEQYTVTCIAPDAKPPAEI------TIFRDGE-ELLESESYTMSGSQD 186

  Fly   327 GTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPP----VVKVSPSAIT 387
            ...:|.:|:...|...::.|...|.|:|..    ..:.:.:.:|::|.:||    ::.:....:.
Zfish   187 KLQNTHAEVTIRARSSDDTRRLTCRAKNPA----SPRALETGMTMKVYFPPQAPMIMGLENEEVK 247

  Fly   388 ANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEK-EDIGNYS 451
            |. |.:.::...|..||  |..:.|.:|..:::.:....:.   |...:.|:|...| ||  |::
Zfish   248 AG-SFLKVVCMSYGGNP--LATLHWTKNGEVLSTSWDVDFV---SRRASSVLKMEVKPED--NHA 304

  Fly   452 ---CQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVR 513
               ||..|.:.:........|.|.:.| .|:.::......|.:|.|  |.|:...:||.|  .:|
Zfish   305 VLQCQSINQVTRSPMSLTRTLTVPFEP-AEVTLLGSFEAVEGEEIN--LSCSTSSSNPPV--HIR 364

  Fly   514 WYANSTLLKELPDCE-----------ETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGP 567
            |:..   .|||...|           .|..:|.|    |:..|..|    .:..||.||......
Zfish   365 WWLG---FKELNRTEVTFAEGDNGGMMTVSNLTH----KVSREDNG----LSLQCEAFNKGTRFS 418

  Fly   568 RSEDKELLVHYEPGPAALSHFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLRGG----------- 621
            .....||:|:|.|....|...|.........|........|...:.:..||:..           
Zfish   419 SVRAAELIVYYPPQKVWLDAPPPNVFLHSGSTLRLVCFSSGGNPTGQLTWLKNNKVVLTASKQVS 483

  Fly   622 --RGPLQDIVTKDWTVEPVGLDSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILH 684
              ||..::::.   |:.|  .|:...|.|.:.|:..|.:.|.....|..|...:|.:.....:..
Zfish   484 SERGVSRELLL---TLHP--SDNLATYRCDSSNKAKKVLSAQTKFRVLFPAVSVKIVAKQKELRR 543

  Fly   685 SSPNATLTCRIECV-----PRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHF 744
            ..     |..::|:     |..:|||....|.:           |.:|.:|...:|..|...   
Zfish   544 GQ-----TLDLDCLAGSSNPTANISWSLGPVIL-----------KGVDQAPKRAEFGGMSRT--- 589

  Fly   745 NMPNWPDSKFNIEADNANY----SCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQED-- 803
                   ||.::..:..::    :|.:..|::...:.:.....:.:.||.:....:.|.|.||  
Zfish   590 -------SKLSLTLEPHHWRKRITCQAFSNVLSEGVNNFYSLDVLFPPEFSAEQPDEVQVIEDET 647

  Fly   804 -TIPGRVICKSRANP-EPSYKWIFKNE----------TIANGNALIINTAMNRNDDGTYTCLAYN 856
             |:|.:|    .||| |.:.:|||:.|          |.::....|:|  ::|.|.|.|.....|
Zfish   648 ATLPAKV----SANPDEITCEWIFQGEKLVKERDPRYTFSDWTLEIVN--VSRRDGGDYIIECSN 706

  Fly   857 KHGSSIAKTVIKVQFKPRCEIERQ----EIDDQDTLICTAYGNPIEAD-FSWSIKTENETDENLG 916
            ..||:..|..:.||:.|...::..    .|.|...|:|.|..|||.:. |||....|.|.|| ||
Zfish   707 AEGSNRTKLRLDVQYSPTVRMKSDPVFVNIGDTADLLCVADANPITSSMFSWKWMGEGERDE-LG 770

  Fly   917 SGKKENSVEKSFYILQTDYAISR----TYRCVANNTVGYGPFCEIE------VAEQLAWWQLWEK 971
                |.|.:....:| |.|.::|    .|:|.|:|  |..|...:|      .|..|.....|.|
Zfish   771 ----EESEDDGTGVL-TIYEVTRDRAGVYQCTADN--GISPTGSVEGQLIVRFAPDLQKGPQWRK 828

  Fly   972  971
            Zfish   829  828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nrmNP_001246890.1 Ig 44..152 CDD:299845
Ig 176..248 CDD:299845 23/94 (24%)
Ig 277..354 CDD:299845 21/79 (27%)
IG_like 383..463 CDD:214653 18/83 (22%)
Ig 394..463 CDD:143165 16/72 (22%)
Ig_3 585..652 CDD:290638 13/79 (16%)
Ig 685..>719 CDD:299845 7/38 (18%)
IG_like 788..869 CDD:214653 28/94 (30%)
Ig <811..869 CDD:299845 19/68 (28%)
nphs1NP_001035777.1 IG_like 33..126 CDD:214653 21/96 (22%)
Ig 133..216 CDD:386229 22/89 (25%)
Ig 261..313 CDD:386229 14/58 (24%)
Ig 333..419 CDD:386229 25/100 (25%)
ig 439..511 CDD:365836 12/76 (16%)
IG_like 637..719 CDD:214653 26/87 (30%)
Ig_3 723..800 CDD:372822 27/82 (33%)
Ig_hNephrin_like 814..922 CDD:143250 4/15 (27%)
FN3 921..1012 CDD:238020
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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