DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and Nphs1

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_072150.1	Gene:	Nphs1 / 64563	RGDID:	620460	Length:	1252	Species:	Rattus norvegicus

Alignment Length:	1220	Identity:	270/1220 - (22%)
Similarity:	418/1220 - (34%)	Gaps:	368/1220 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 ERQSLKATCTVRNTRPQPEVSWFR------------GTKRLTTYSPTHDLVDGLYTSTLELDWTL 231
            |..::|..|.||  .|...|.|.:            |..|   ||...|...|      |....:
  Rat    59 EGTTVKLWCGVR--APGSVVQWAKDGLLLGPNPKMPGFPR---YSLEGDRAKG------EFHLLI 112

  Fly   232 SREDLAQD--IECRV-KSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHT---VQGSKVVLTCDIH 290
            ...||:.|  .||:| :|.....:...|..:.:.|.|..:.:......|   |.|.:.|:||...
  Rat   113 EACDLSDDAEYECQVGRSELGPELVSPKVILSILVSPKVLLLTPEAGSTVTWVAGQEYVVTCVSG 177

  Fly   291 GARPAVNLTWY---NTTTIISSGENE-------ITEVRSKSLEKSDGTFHTQSELIFNATRFEND 345
            .|:||.::|:.   .|...:||..||       |||..::.:.:|.                :|.
  Rat   178 DAKPAPDITFIQSGRTILDVSSNVNEGSEEKLCITEAEARVIPQSS----------------DNG 226

  Fly   346 RVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAIT--------ANTSEIVLLNCEYFA 402
            ::..||..|..|    :.||.::.|:.:|:||    .|..|.        ....|.:.|.|....
  Rat   227 QLLVCEGSNPAL----DTPIKASFTMNILFPP----GPPVIDWPGLNEGHVRAGENLELPCTARG 283

  Fly   403 N--PASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIG-NYSCQLSNNIGKGTSD 464
            .  ||:|   :|.:|...|:....|.:....:.:|  ::.:...||.| ..|||..|::..||.:
  Rat   284 GNPPATL---QWLKNGKPVSTAWGTEHAQAVAHSV--LVMTVRPEDHGARLSCQSYNSVSAGTQE 343

  Fly   465 QKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRWYANSTLLKELPDCEE 529
            :.|.|.|.:.|:...::   |.|.:|:..||||.|....:.|.||  :||:.....|  ||..|.
  Rat   344 RSITLQVTFPPSAITIL---GSVSQSENKNVTLCCLTKSSRPRVL--LRWWLGGRQL--LPTDET 401

  Fly   530 TREDL--CHIDPSKL--LLESIGRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALSHFPL 590
            ..:.|  .||..|.|  |:.....|.  ..:||.|:.|      ..||..
  Rat   402 VMDGLHGGHISMSNLTFLVRREDNGL--PLTCEAFSDA------FSKETF--------------- 443

  Fly   591 VAVKKKSVTFSCS-------VDDPGFPESNRFR---------------------WLRGG------ 621
                |||:|.:..       ::.|  ||....|                     |.:..
  Rat   444 ----KKSLTLNVKYPAQKLWIEGP--PEGQYIRTGTRVRLVCLAIGGNPDPSLIWFKDSRPVSEP 502

  Fly   622 RGPLQDIVTKDWTVEPVGL-------------DSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFI 673
            |.|.:....:..:||..|.             |:|..:||.|    |: :.|:..|.|..||..:
  Rat   503 RQPQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNRAKFSCKA----GQ-LSASTQLVVQFPPTNL 562

  Fly   674 KNLPPYTGILHSSPNATLTC-RIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFES 737
            ..| ..:..|.......||| .|...|..::||.|:|..:|.           :.|.|.:..|:.
  Rat   563 TIL-ANSSALRPGDALNLTCVSISSNPPVNLSWDKEGERLED-----------VAAKPQSAPFKG 615

  Fly   738 MLSVLHFNMPNWPDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQE 802
            ..:.....:      :.:........:|.:....:..::.|...|.:.|.||........|.|.|
  Rat   616 SAASRSVFL------RVSSRDHGQRVTCRAHSEALRETVSSFYRFNVLYPPEFLGEQVRAVTVVE 674

  Fly   803 DTIPGRVI--CKSRANPEP-SYKWIFK----------NETIANGNALIINTAMNRNDDGTYTCLA 854
            .   |:|:  ....|||.| ::.|.|:          ...|.:|.||.: ..:.|.|||.|....
  Rat   675 Q---GQVLLPVSVSANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQL-WNVTRADDGFYQLHC 735

  Fly   855 YNKHGSSIAKTVIKVQFKPRCEIERQ----EIDDQDTLICTAYGNPIEAD-FSWSIKTENETDEN 914
            .|..|::.|...:.|.:.|.....|.    .:.....::||...|||..: |||....|.|.|.|
  Rat   736 QNSEGTAEALLKLDVHYAPTIRALRDPTEVNVGGSVDIVCTVDANPILPEMFSWERLGEEEEDLN 800

  Fly   915 LGSGKKENSVEKS----FYILQTDYAISRTYRCVANNTVGYGPFCE------IEVAEQLAWWQLW 969
            |...:|   |.|.    ..|.|...:.:..|:|:.:|  |..|...      :..|.|:
  Rat   801 LDDMEK---VSKGSTGRLRIRQAKLSQAGAYQCIVDN--GVAPAARGLVRLVVRFAPQV------ 854

  Fly   970 EKNTLIILVAAILGLLLTVIVICCIIICICRRRRR------------------QDKYLTEVPINS 1016
            ::.|.:..|||......:..:.|         |.|                  ||...||...:.
  Rat   855 DQPTPLTKVAAAGDSTSSATLHC---------RARGVPNIDFTWTKNGVPLDLQDPRYTEHRYHQ 910

  Fly  1017 --IQSALSDQLDMSRAGRNLSTQD----KCTAI----------------LPNPS-SSRFIGSAPK 1058
              :.|:|....::|.|      ||    ||||.                .|:|. ..:.:..:|.
  Rat   911 GVVHSSLLTIANVSAA------QDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVSISPH 969

  Fly  1059 S-------------PPRWPIR------PGVMLHVSSNTKENLTVNRMTVKP-----------NVS 1093
            |             |.|:.||      || .|||.....:..|.....:||           |..
  Rat   970 SVGLEWKPGFDGGLPQRFQIRYEALETPG-FLHVDVLPTQATTFTLTGLKPSTRYRIWLLASNAL 1033

  Fly  1094 GNRGDMSQLSAQLSAALNG---SRDNSDGTILTEIS-------------AVSGENEASNLSIL-- 1140
            |:.| ::....|:|....|   :.:::|..:.||:.             ||.|....||.|.:
  Rat  1034 GDSG-LTDKGIQVSVTTPGPDQAPEDTDHQLPTELPPGPPRLPLLPVLFAVGGLLLLSNASCVGG 1097

  Fly  1141 ------------EVTNRKKATVPSTIRN-----------------VSTAE 1161
                        |::.:.:|.....|||                 |||||
  Rat  1098 LLWRRRLRRLAEEISEKTEAGSEDRIRNEYEESQWTGDRDTRSSTVSTAE 1147

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	22/83 (27%)
		Ig	277..354	CDD:299845	22/89 (25%)
		IG_like	383..463	CDD:214653	21/90 (23%)
		Ig	394..463	CDD:143165	18/71 (25%)
		Ig_3	585..652	CDD:290638	19/113 (17%)
		Ig	685..>719	CDD:299845	10/34 (29%)
		IG_like	788..869	CDD:214653	25/93 (27%)
		Ig	<811..869	CDD:299845	18/68 (26%)
Nphs1	NP_072150.1	Ig	52..128	CDD:299845	20/79 (25%)
		IG_like	52..127	CDD:214653	20/78 (26%)
		C2-set_2	155..242	CDD:285423	24/106 (23%)
		Ig_3	256..335	CDD:290638	19/83 (23%)
		IG_like	268..350	CDD:214653	22/86 (26%)
		C2-set_2	358..440	CDD:285423	28/96 (29%)
		I-set	460..555	CDD:254352	18/101 (18%)
		Ig	472..555	CDD:299845	14/87 (16%)
		Ig	563..646	CDD:299845	16/100 (16%)
		IG_like	670..750	CDD:214653	23/83 (28%)
		Ig	676..750	CDD:299845	20/74 (27%)
		Ig_3	753..834	CDD:290638	22/83 (27%)
		IG_like	762..848	CDD:214653	23/90 (26%)
		Ig	848..956	CDD:299845	23/128 (18%)
		IG_like	859..949	CDD:214653	20/104 (19%)
		FN3	955..1049	CDD:238020	21/95 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1043..1067		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1113..1144		4/30 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810