DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and Psgb1

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	XP_006228526.1	Gene:	Psgb1 / 59313	RGDID:	727932	Length:	472	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	105/515 - (20%)
Similarity:	178/515 - (34%)	Gaps:	135/515 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ISLSLVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKL-HSLN-------WFKGDD 81
            |.|:...:.|..|  |:|:||  ||      .:|.|..|:.|....| |.|.       |:||..
  Rat    18 ILLTASFLTCWHL--STTSQV--TI------ELVPPQVVEGEDVLFLVHKLPENLIGFCWYKGSP 72

  Fly    82 RI---AAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFN 143
            .|   .|:...::.|......:..|.|:.:|...|:        .::...||.|:    ....||
  Rat    73 IIKHGIALYEANTKVGVAGPMYSARETLYRNGSMLI--------HNVTQKDTGFY----RLRIFN 125

  Fly   144 GYR----------------------------IELRVLVPPTEVVILDAKGDRIKNGSVVGPMQER 180
            .:|                            ||   .:||   ::.|.|.
  Rat   126 RHRDTMLTSTFLHVNLFLWNCGHLVASGRPSIE---TLPP---IVQDGKD--------------- 169

  Fly   181 QSLKATCTVRNTRPQPE----VSWFRGTKRLTT---------------YSPTHDLVDGLYTSTLE 226
                   .|...|..||    .:||:|..:.||               :.|.....:.|||....
  Rat   170 -------VVLQVRNLPENLLGFAWFKGMTQATTHLIGRYIIEENPSFSFGPASSGREKLYTDGSL 227

  Fly   227 LDWTLSRED--------LAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKV 283
            |...::::|        |..|::.:.....|| |....|.....:.|..|.:..|..|..:|..|
  Rat   228 LIENVTQKDAGLYTLGILGTDMKSQEAHGEIQ-VESLVFQCCNSLTPAKILVEPVPRHAAEGESV 291

  Fly   284 VLTCDIHG-ARPAVNLTWYNTTTIISS----GENEITEVRS-KSLEKSDGTFHTQSELIFNATRF 342
            :|.  :|. .:..::.||||:...:.:    ..:.|..:.: ....:..|..:....|:......
  Rat   292 LLL--VHYLPKELISFTWYNSMYTVPTFKIVNHHVIGNITTWGDAYRGRGMLYVSGSLLLQDITK 354

  Fly   343 ENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASL 407
            ::.|::..|..||..::  ||........|.:..|.::|  :.||...|..|..:|   .:|.:.
  Rat   355 DDARMYTLETLNINNKV--EKAHVQFYVNEPVTQPFIRV--ANITVKGSRSVTFSC---VSPHTG 412

  Fly   408 TQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKI 467
            ..:.|:.|:..:...|.|..   :.....|.|....:||.|.|.|::.:..|||...|.:
  Rat   413 ISIHWFFNNHNLKFTDRTKL---SPSKCGLRIDDVRREDAGEYKCEVIDRAGKGVVSQPV 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	29/146 (20%)
		Ig	176..248	CDD:299845	17/98 (17%)
		Ig	277..354	CDD:299845	13/82 (16%)
		IG_like	383..463	CDD:214653	20/79 (25%)
		Ig	394..463	CDD:143165	17/68 (25%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Psgb1	XP_006228526.1	Ig_CEACAM_D1	36..139	CDD:143251	26/122 (21%)
		Ig_CEACAM_D1	155..260	CDD:143251	25/133 (19%)
		Ig	278..380	CDD:299845	19/105 (18%)
		IG_like	393..462	CDD:214653	17/74 (23%)
		IGc2	400..461	CDD:197706	14/66 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000