DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and Psg26

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001025064.1	Gene:	Psg26 / 574429	MGIID:	1891358	Length:	475	Species:	Mus musculus

Alignment Length:	464	Identity:	95/464 - (20%)
Similarity:	165/464 - (35%)	Gaps:	126/464 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 ATCTVRNTRPQ--------------PE----VSWFRGTKRLTTYSPTHDL-----VDGLYTS--- 223
            |..|:.:..||              ||    ..|:||...|......|.|     |.||..|
Mouse    34 ARVTIESLPPQVVEGENVLLRVDNMPENLLVFGWYRGMTNLRQAIALHSLYYSVTVKGLKHSGRE 98

  Fly   224 TLELDWTLSREDLAQDIE--CRVKSAAIQNVTVTKFSVDLQV--------RPTSI---DINGVKH 275
            ||.::.||..:::.|:..  ...::.:.|...|:..|:.|.|        |||::   .|..|..
Mouse    99 TLYINGTLWIQNVTQEDTGYYTFQTISKQGEMVSNTSLYLHVYSSLFICGRPTTLVGPTIELVPA 163

  Fly   276 HTVQGSKVVLTCDIHG-ARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFN- 338
            ....|..|:|.  :|. .:...:|.||.  .:|...:.||...|.....:..|..|:..|.:::
Mouse   164 SVAAGGSVLLL--VHNIPKYLQSLFWYK--GLIVFNKVEIARYRRAKKSRESGPAHSGRETVYSN 224

  Fly   339 --------------------ATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSP 383
                                .||::     :.|..:|.||::    .|.:|..:.|....:.:.|
Mouse   225 GSLLLQNVTWKDTGFYTLRTLTRYQ-----KMEFAHIYLQVD----TSLSLCCDTLDSAQLSIDP 280

  Fly   384 SAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYK------------GGNSE--- 433
            ....|.....|||.....  |..|....||:     .|..|..:|            .|.:.
Mouse   281 VPQHAAEGGSVLLQVHNL--PEGLQAFSWYK-----GVLSTQDFKIAEYSIATKSIIRGRAHSRR 338

  Fly   434 -----NVALVIKSTEKEDIGNYS-CQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESD- 491
                 |.:|:::...::|.|.|: ..:.:|:...|:..::|:.       :::..|...|.:|.
Mouse   339 EIGYTNGSLLLQDVTEKDSGLYTLITIDSNVRILTAHVQVNIH-------KLVTQPAMRVTDSTV 396

  Fly   492 --ESNVTLFCNVLDANPSVLTKVRWYANSTLLKELPDCEETREDLCHIDPSK--LLLESIGRGFF 552
              :|:|...|  ...|..:  .:||..|:..|:        ..:...:.|||  |.:.::.:...
Mouse   397 RVQSSVVFTC--FSYNTGI--SIRWLFNNQSLQ--------LTERMTLSPSKCQLRIHTVRKEDA 449

  Fly   553 YNYSCEGFN 561
            ..|.||.||
Mouse   450 GEYQCEAFN 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	21/90 (23%)
		Ig	277..354	CDD:299845	17/98 (17%)
		IG_like	383..463	CDD:214653	19/100 (19%)
		Ig	394..463	CDD:143165	17/89 (19%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Psg26	NP_001025064.1	Ig_CEACAM_D1	36..140	CDD:143251	24/103 (23%)
		IG_like	45..137	CDD:214653	20/91 (22%)
		Ig_CEACAM_D1	156..260	CDD:143251	21/112 (19%)
		Ig_CEACAM_D1	276..378	CDD:143251	20/108 (19%)
		IG_like	395..472	CDD:214653	17/76 (22%)
		IGc2	400..461	CDD:197706	17/71 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000