Protein Alignment nrm and CRTAM

DIOPT Version :9

• Sequence 1: NP_001246890.1
• Gene: nrm / 40515
• FlyBaseID: FBgn0262509
• Length: 2192
• Species: Drosophila melanogaster
• Sequence 2: NP_062550.2
• Gene: CRTAM / 56253
• HGNCID: 24313
• Length: 393
• Species: Homo sapiens
• Alignment Length: 488
• Identity: 93/488 - (19%)
• Similarity: 171/488 - (35%)
• Gaps: 129/488 - (26%)

  Fly    29 LVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDRIAAMLLGDSNV 93
            |.|:....|.::|......||:.:|.|::.|.|.....|..   ||.|           |..|..
Human     6 LSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNS---SLQW-----------LTPSGF 56

  Fly    94 TSVNKEFDERVTVEQNPYRLV----------IKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIE 148
            |....|:.   .::.:.|:|:          :.::.:.||.:|.|       ....|:.:...::
Human    57 TIFLNEYP---ALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKC-------LHYSDSVSTKEVK 111

  Fly   149 LRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPT 213
            :.||..|.: .||:|...|.:||        .:.:...|:...::|.|:::|..|.....:....
Human   112 VIVLATPFK-PILEASVIRKQNG--------EEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTL 167

  Fly   214 HDL-VDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHT 277
            |:. .||.                    :|...|..|.:......:||..:|          |..
Human   168 HEFETDGK--------------------KCNTTSTLIIHTYGKNSTVDCIIR----------HRG 202

  Fly   278 VQGSKVV-------LTCDIHGARPAVNLTWYN-------TTTIISSGENEITEVRSKSLEKSDGT 328
            :||.|:|       |..|...|..|:.....:       |:|:..:.::..:|:..:..|::
Human   203 LQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQT--- 264

  Fly   329 FHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEI 393
              ||            |.....||....|.:.|:|   |.:.|..|...::            .|
Human   265 --TQ------------DPDLTTEANPQYLGLARKK---SGILLLTLVSFLI------------FI 300

  Fly   394 VLLNCEYFANPASLTQVEWYR-NDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNN 457
            :.:..:.|........|.|.: |::..:..::...:..|.|.     .|.||....::..:..|.
Human   301 LFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEET-----SSEEKNGQSSHPMRCMNY 360

  Fly   458 IGKGTSDQKINL--DVQYAPTVE-ILMIPEGPV 487
            |.|..|:.|...  :||::...| .:.:||..|
Human   361 ITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	21/117 (18%)
		Ig	176..248	CDD:299845	10/72 (14%)
		Ig	277..354	CDD:299845	17/90 (19%)
		IG_like	383..463	CDD:214653	13/80 (16%)
		Ig	394..463	CDD:143165	12/69 (17%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
CRTAM	NP_062550.2	Ig	20..114	CDD:299845	21/117 (18%)
		IG_like	24..114	CDD:214653	21/113 (19%)
		Ig	121..207	CDD:299845	23/123 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..273		8/64 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	328..354		5/30 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..393		5/18 (28%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q149L7	390..393		1/2 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910