DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and SIRPG

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens

Alignment Length:	376	Identity:	77/376 - (20%)
Similarity:	133/376 - (35%)	Gaps:	74/376 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKLHSLN-------------WFKGD 80
            |:|.|.|.|         |.::.:|...::.|..:.....||..:|:             ||:|.
Human    15 LLLTLLLGL---------TEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGV 70

  Fly    81 DRIAAMLLGDS-----NVTSVNKEFDERVTVEQN-PYRLVIKDLKIADEDIYLCDTTFFIPEETC 139
            .....::....     .||:|:.     :|...| .:.:.|..:..||...|.|........|..
Human    71 GPGRELIYNQKEGHFPRVTTVSD-----LTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENV 130

  Fly   140 DNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQE---RQSLKATCTVRNTRPQP-EVSW 200
            :..:|...|:.:...|:..|:|             ||...   ..::..||......|:. .:.|
Human   131 EFKSGPGTEMALGAKPSAPVVL-------------GPAARTTPEHTVSFTCESHGFSPRDITLKW 182

  Fly   201 FRGTKRL----TTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTV---TKFS 258
            |:....|    |...||...|.....||..:  .|...|:...:.|.|....:|...:   ...|
Human   183 FKNGNELSDFQTNVDPTGQSVAYSIRSTARV--VLDPWDVRSQVICEVAHVTLQGDPLRGTANLS 245

  Fly   259 VDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARP-AVNLTWYNTTTIISSGENEITEVRSKSL 322
            ..::|.||   :...:.....|::|.:||.:....| ::.|||.....:..      .|..|...
Human   246 EAIRVPPT---LEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQ------RETASTLT 301

  Fly   323 EKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEV 373
            |..|||::..|..:.|.:...:|.|..|:.::     :.:..:|..|.|||
Human   302 ENKDGTYNWTSWFLVNISDQRDDVVLTCQVKH-----DGQLAVSKRLALEV 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	22/126 (17%)
		Ig	176..248	CDD:299845	17/79 (22%)
		Ig	277..354	CDD:299845	19/77 (25%)
		IG_like	383..463	CDD:214653
		Ig	394..463	CDD:143165
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	20/114 (18%)
		IgC_SIRP_domain_2	145..248	CDD:319314	23/117 (20%)
		IgC_SIRP_domain_3	250..353	CDD:319334	27/112 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910