DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and Nphs1

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_062332.2	Gene:	Nphs1 / 54631	MGIID:	1859637	Length:	1256	Species:	Mus musculus

Alignment Length:	1225	Identity:	271/1225 - (22%)
Similarity:	421/1225 - (34%)	Gaps:	361/1225 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 KNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR------------GTKRLTTYSPTHDLVDGLY 221
            :|.:||    |..::|..|.||  .|...|.|.:            |..|   ||...|...|
Mouse    53 ENLTVV----EGSTVKLWCGVR--APGSVVQWAKDGLLLGPNPKIPGFPR---YSLEGDSAKG-- 106

  Fly   222 TSTLELDWTLSREDLAQD--IECRV-KSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHT---VQG 280
                |....:...||:.|  .||:| :|.....:......:.:.|.|..:.:......|   |.|
Mouse   107 ----EFHLLIEACDLSDDAEYECQVGRSELGPELVSPSVILSILVSPKVLQLTPEAGSTVTWVAG 167

  Fly   281 SKVVLTCDIHGARPAVNLTWY---NTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRF 342
            .:.|:||....|:||.::.:.   .|...:||..||.:|      ||   .|.|::|........
Mouse   168 QEYVVTCVSGDAKPAPDIIFIQGGRTVEDVSSSVNEGSE------EK---LFFTEAEARVTPQSS 223

  Fly   343 ENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAIT--------ANTSEIVLLNC- 398
            :|.::..||..|..|    ..||.::.|:.:|:||    .|..|.        ....|.:.|.|
Mouse   224 DNGQLLVCEGSNPAL----ATPIKASFTMNILFPP----GPPVIDWPGLNEGHVRAGENLELPCI 280

  Fly   399 EYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIG-NYSCQLSNNIGKGT 462
            ....||.:..|  |.:|...|::...|.:....:.:|  ::.:...||.| ..|||..|::...|
Mouse   281 ARGGNPPATLQ--WLKNGKPVSIAWGTEHAQAVAHSV--LVMTVRPEDHGARLSCQSYNSVSAET 341

  Fly   463 SDQKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRWYANSTLLKELPDC 527
            .::.|.|.|.:.|:...::   |...:|:..||||.|....:.|.||  :||:.....|  ||..
Mouse   342 QERSITLQVTFPPSAVTIL---GSTSQSENKNVTLCCLTKSSRPRVL--LRWWLGGRQL--LPTD 399

  Fly   528 EETREDL--CHIDPSKLLL----ESIGRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALS 586
            |...:.|  .||..|.|.|    |..|    .:.:||.|:.|      ..||..
Mouse   400 ETVMDGLHGGHISMSNLTLLVKREDNG----LSLTCEAFSDA------FSKETF----------- 443

  Fly   587 HFPLVAVKKKSVTFSCS-------VDDPGFPESNRFR---------------------WLRGGRG 623
                    |||:|.:..       ::.|  ||....|                     ||:..|
Mouse   444 --------KKSLTLNVKYPAQKLWIEGP--PEGQSIRTGTRVRLVCLAIGGNPEPSLTWLKDSR- 497

  Fly   624 PLQDIVTKD-------WTVEPVGL-------------DSRTNYSCYAYNEGGKGVMATVNLEVHA 668
            |:.|.....       .:||..|.             |:...:||.|    |: :.|:..|.|..
Mouse   498 PVNDPRQSQEPRRVQLGSVEKSGSTFSRELVLIIGPPDNLAKFSCKA----GQ-LSASTQLVVQF 557

  Fly   669 PPFFIKNLPPYTGILHSSPNATLTC-RIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPAT 732
            ||..:..| ..:..|.......||| .|...|..::|..|:|   ||.|.        :.|.|.:
Mouse   558 PPTNLTIL-ANSSALRPGDALNLTCVSISSNPPVNLSLDKEG---ERLDD--------VAAKPQS 610

  Fly   733 GDFE-SMLSVLHFNMPNWPDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSEN 796
            ..|: |..|...|...:..|....:       :|.:....:..::.|.....:.|.||.......
Mouse   611 APFKGSAASRSVFLRVSSRDHGHRV-------TCRAHSEALRETVSSFYRLNVLYPPEFLGEQVR 668

  Fly   797 IVYVQED---TIPGRVICKSRANPEP-SYKWIFK----------NETIANGNALIINTAMNRNDD 847
            .|.|.|.   .:|..|    .|||.| ::.|.|:          ...|.:|.||.: ..:.|.||
Mouse   669 AVTVVEQGQALLPVSV----SANPAPEAFNWTFRGYRLSPAGGPRHRILSGGALQL-WNVTRADD 728

  Fly   848 GTYTCLAYNKHGSSIAKTVIKVQFKPRCEIERQ----EIDDQDTLICTAYGNPIEAD-FSWSIKT 907
            |.|.....|..|::.|...:.|.:.|.....:.    .:.....::||...|||..: |||....
Mouse   729 GFYQLHCQNSEGTAEALLKLDVHYAPTIRALKDPTEVNVGGSVDIVCTVDANPILPEMFSWERLG 793

  Fly   908 ENETDENLGSGKKENSVEKS-FYILQTDYAISRTYRCVANNTVGYGPFCE------IEVAEQLAW 965
            |:|.:.||...:|.:..... ..|.|...:.:..|:|:.:|  |..|...      :..|.|:
Mouse   794 EDEEELNLDDMEKMSKGSTGRLRIRQAKLSQAGAYQCIVDN--GVAPAARGLVRLVVRFAPQV-- 854

  Fly   966 WQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRR------------------QDKYLTEV 1012
                :..|.:..|||......:..:.|         |.|                  ||...||.
Mouse   855 ----DHPTPLTKVAAAGDSTSSATLHC---------RARGVPNIDFTWTKNGVPLDLQDPRYTEH 906

  Fly  1013 PINS--IQSALSDQLDMSRAGRNLSTQD----KCTAI----------------LPNPS-SSRFIG 1054
            ..:.  :.|:|....::|.|      ||    ||||.                .|:|. ..:.:.
Mouse   907 KYHQGVVHSSLLTIANVSAA------QDYALFKCTATNALGSDHTNIQLVSISRPDPPLGLKVVS 965

  Fly  1055 SAPKS-------------PPRWPIR------PGVMLHVSSNTKENLTVNRMTVKP---------- 1090
            .:|.|             |.|:.||      || .|::.....:..|.....:||
Mouse   966 VSPHSVGLEWKPGFDGGLPQRFQIRYEALESPG-FLYMDVLPAQATTFTLTGLKPSTRYRIWLLA 1029

  Fly  1091 -NVSGNRGDMSQLSAQLS---AALNGSRDNSDGTILTE-------------ISAVSGENEASNLS 1138
             |..|:.| ::....|:|   ..|:.:.:::|..:.||             :.||.|....||.|
Mouse  1030 SNALGDSG-LTDKGIQVSITTPGLDQAPEDTDQPLPTEQPPGPPRLPLLPVLFAVGGLLLLSNAS 1093

  Fly  1139 IL--------------EVTNRKKA-TVPSTIRN-----------------VSTAE 1161
            .:              |::.:.:| :....|||                 |||||
Mouse  1094 CVGGLLWRRRLRRLAEEISEKTEAGSEEDRIRNEYEESQWTGDRDTRSSTVSTAE 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	22/86 (26%)
		Ig	277..354	CDD:299845	23/82 (28%)
		IG_like	383..463	CDD:214653	20/89 (22%)
		Ig	394..463	CDD:143165	17/70 (24%)
		Ig_3	585..652	CDD:290638	20/114 (18%)
		Ig	685..>719	CDD:299845	11/34 (32%)
		IG_like	788..869	CDD:214653	25/94 (27%)
		Ig	<811..869	CDD:299845	18/68 (26%)
Nphs1	NP_062332.2	Ig	52..128	CDD:299845	23/89 (26%)
		IG_like	52..127	CDD:214653	23/88 (26%)
		C2-set_2	155..242	CDD:285423	25/99 (25%)
		Ig	254..332	CDD:299845	18/85 (21%)
		IG_like	268..350	CDD:214653	21/85 (25%)
		C2-set_2	358..440	CDD:285423	28/98 (29%)
		Ig	459..544	CDD:299845	15/87 (17%)
		I-set	460..555	CDD:254352	19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..516		5/25 (20%)
		Ig	563..646	CDD:299845	21/101 (21%)
		IG_like	670..750	CDD:214653	23/84 (27%)
		Ig	676..750	CDD:299845	20/78 (26%)
		Ig_3	753..834	CDD:290638	18/80 (23%)
		IG_like	762..848	CDD:214653	20/87 (23%)
		Ig	848..956	CDD:299845	23/128 (18%)
		IG_like	859..949	CDD:214653	20/104 (19%)
		fn3	956..1039	CDD:278470	16/84 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1048..1071		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1143		4/30 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810