DRSC/TRiP Functional Genomics Resources

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Protein Alignment nrm and NPHS1

DIOPT Version :9

Sequence 1:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster
Sequence 2:NP_004637.1 Gene:NPHS1 / 4868 HGNCID:7908 Length:1241 Species:Homo sapiens


Alignment Length:894 Identity:195/894 - (21%)
Similarity:339/894 - (37%) Gaps:181/894 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 FFIPEETCDNFNGYRIELR--VLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRP 194
            |:...|......|..:|||  |..|.:.|       ...|:|.::|                  |
Human    34 FWALPENLTVVEGASVELRCGVSTPGSAV-------QWAKDGLLLG------------------P 73

  Fly   195 QPEVSWFRGTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQD--IECRV-KSAAIQNVTVTK 256
            .|.:..|      ..|....|...|      |....:...||:.|  .||:| :|.....:...:
Human    74 DPRIPGF------PRYRLEGDPARG------EFHLHIEACDLSDDAEYECQVGRSEMGPELVSPR 126

  Fly   257 FSVDLQVRPTSIDIN---GVKHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEVR 318
            ..:.:.|.|..:.:.   |.....|.|.:.|:.|....|:||.::      ||:.||:. |:::.
Human   127 VILSILVPPKLLLLTPEAGTMVTWVAGQEYVVNCVSGDAKPAPDI------TILLSGQT-ISDIS 184

  Fly   319 SKSLEKS-DGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVS 382
            :...|.| ...|..::.........:|.::..|||.:..|    |.||.::.|:.||:||    .
Human   185 ANVNEGSQQKLFTVEATARVTPRSSDNRQLLVCEASSPAL----EAPIKASFTVNVLFPP----G 241

  Fly   383 PSAIT--------ANTSEIVLLNC-EYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALV 438
            |..|.        ....:.:.|.| ....||  |..::|.:|...|:....|.:....:.:|  :
Human   242 PPVIEWPGLDEGHVRAGQSLELPCVARGGNP--LATLQWLKNGQPVSTAWGTEHTQAVARSV--L 302

  Fly   439 IKSTEKEDIG-NYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESNVTLFCNVL 502
            :.:...||.| ..||:..|::..||.:..|.|.|.:.|:..|::   |...:::..||||.|...
Human   303 VMTVRPEDHGAQLSCEAHNSVSAGTQEHGITLQVTFPPSAIIIL---GSASQTENKNVTLSCVSK 364

  Fly   503 DANPSVLTKVRWYANSTLLKELPDCEETREDLC---HIDPSKLLLESIGRGFFYNYSCEGFNAAG 564
            .:.|.||  :||:..   .::|...|||..|..   ||..|.|...:.........:||.|:.| 
Human   365 SSRPRVL--LRWWLG---WRQLLPMEETVMDGLHGGHISMSNLTFLARREDNGLTLTCEAFSEA- 423

  Fly   565 WGPRSEDKELLVHYE-PGPAALSHFPLVAVKKKS---VTFSCSVDDPGFPESNRFRWLRGGRGPL 625
            :...:..|.|:::.: |........|....|.::   |...| :...|.||.: ..|.:..|...
Human   424 FTKETFKKSLILNVKYPAQKLWIEGPPEGQKLRAGTRVRLVC-LAIGGNPEPS-LMWYKDSRTVT 486

  Fly   626 QDIVTKD------WTVEPVG-------------LDSRTNYSCYAYNEGGKGVMATVNLEVHAPPF 671
            :..:.::      .:||..|             .|::..::|.|    |: :.|:..|.|..||.
Human   487 ESRLPQESRRVHLGSVEKSGSTFSRELVLVTGPSDNQAKFTCKA----GQ-LSASTQLAVQFPPT 546

  Fly   672 FIKNLPPYTGILHSSPNATLTC-RIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDF 735
            .:..| .....|.......||| .:...|..::||.|:|..:|.           :.|.|....|
Human   547 NVTIL-ANASALRPGDALNLTCVSVSSNPPVNLSWDKEGERLEG-----------VAAPPRRAPF 599

  Fly   736 E---SMLSVLHFNMPNWPDSKFNIEADNANY----SCVSTGNIVGGSIRSRTYFGIEYAPENTTV 793
            :   :..|||             ::..:.::    :|.:....:..::.|.....:.|.||  .:
Human   600 KGSAAARSVL-------------LQVSSRDHGQRVTCRAHSAELRETVSSFYRLNVLYRPE--FL 649

  Fly   794 SENIVYVQ-----EDTIPGRVICKSRANPEP-SYKWIF-----------KNETIANGNALIINTA 841
            .|.::.|.     |..:|..|    .|||.| ::.|.|           ::..:::|...:.|  
Human   650 GEQVLVVTAVEQGEALLPVSV----SANPAPEAFNWTFRGYRLSPAGGPRHRILSSGALHLWN-- 708

  Fly   842 MNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKP--RCEIERQEID--DQDTLICTAYGNPI-EADF 901
            :.|.|||.|.....|..|::.|:..:.|.:.|  |...:..|::  ....::||...||| ...|
Human   709 VTRADDGLYQLHCQNSEGTAEARLRLDVHYAPTIRALQDPTEVNVGGSVDIVCTVDANPILPGMF 773

  Fly   902 SWSIKTENETDENLGSGKK-ENSVEKSFYILQTDYAISRTYRCVANNTV 949
            :|....|:|.|::|...:| .........|.....|.:..|:|:.:|.|
Human   774 NWERLGEDEEDQSLDDMEKISRGPTGRLRIHHAKLAQAGAYQCIVDNGV 822

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nrmNP_001246890.1 Ig 44..152 CDD:299845 6/21 (29%)
Ig 176..248 CDD:299845 14/74 (19%)
Ig 277..354 CDD:299845 19/77 (25%)
IG_like 383..463 CDD:214653 19/89 (21%)
Ig 394..463 CDD:143165 17/70 (24%)
Ig_3 585..652 CDD:290638 15/88 (17%)
Ig 685..>719 CDD:299845 9/34 (26%)
IG_like 788..869 CDD:214653 23/97 (24%)
Ig <811..869 CDD:299845 16/69 (23%)
NPHS1NP_004637.1 V-set 38..119 CDD:284989 25/117 (21%)
IG_like 38..113 CDD:214653 23/111 (21%)
C2-set_2 141..228 CDD:285423 22/97 (23%)
Ig 240..321 CDD:299845 18/88 (20%)
IG_like 254..336 CDD:214653 20/85 (24%)
Ig 345..424 CDD:299845 24/87 (28%)
Ig 445..530 CDD:299845 14/86 (16%)
I-set 446..541 CDD:254352 18/101 (18%)
Ig 549..632 CDD:299845 18/107 (17%)
IG_like 558..642 CDD:214653 17/107 (16%)
I-set 646..736 CDD:254352 23/97 (24%)
Ig 662..736 CDD:299845 19/79 (24%)
Ig_3 739..820 CDD:290638 19/80 (24%)
IG_like 748..821 CDD:214653 17/72 (24%)
Ig8_hNephrin_like 834..942 CDD:143250
IG_like 845..935 CDD:214653
fn3 942..1023 CDD:278470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1025..1057
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1099..1137
Binds to NPHS2 1160..1241
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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