DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nrm and hbs

DIOPT Version :9

Sequence 1:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster
Sequence 2:NP_001286439.1 Gene:hbs / 44129 FlyBaseID:FBgn0029082 Length:1235 Species:Drosophila melanogaster


Alignment Length:1459 Identity:313/1459 - (21%)
Similarity:515/1459 - (35%) Gaps:413/1459 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 SISLSLVLVLC--LALVDSST--AQVDTTISQQ-----------ESQSVVLPCPVDAEKCGKLHS 73
            :.::.|...:|  :|.|.:.|  |||.....|:           |....:|.|.| :.:.||   
  Fly     8 TFAVHLATTICHVMAAVTAPTPAAQVAAPPVQKFHLTPHDLQILEGTDTLLRCEV-SNRAGK--- 68

  Fly    74 LNWFKGDDRIAAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEET 138
            :.|.|  |..|   ||.|.|......:...|..:||.|.|.||:..:.|:..|.|.    :....
  Fly    69 VQWTK--DGFA---LGFSAVIPGFPRYSVLVDAKQNAYNLQIKNATLEDDAEYQCQ----VGPAA 124

  Fly   139 CDNFNGYRIELRVLVPPTEVVILD-AKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR 202
            .:.......:|.::..|:.:||.. |:..|::       ::|||:|...|...|..|..|:.||:
  Fly   125 GNPAIRANAKLSIVAAPSSIVIEGYARNARVE-------VEERQNLTLHCIAENANPAAEIVWFQ 182

  Fly   203 G----------------TKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQN 251
            |                .||.||            :|||.|.  ...||..::..|..:..|:..
  Fly   183 GEVPVSTAPIVTVNQTAPKRFTT------------SSTLHLQ--PRAEDDYKEFSCEARHKALPP 233

  Fly   252 VTVTKFSVDLQV--RPTSIDINGVKHHTV--QGSKVVLTCDIHGARPAVNLTWYNTTTIISSGEN 312
            ....:..|.|.|  .|.:....|......  :|.:|.:.|...|..|...||||.....|||.:.
  Fly   234 DVPMRAQVQLSVLYPPGAPFFEGYSQGETLHRGQEVQIACRSRGGNPPAQLTWYRNGVAISSPQR 298

  Fly   313 EITEVR-SKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYP 376
              |..| |:::.|            |.|...:|.....|||:|::    ...|:.:.|.|.|||.
  Fly   299 --TSGRLSENVYK------------FTAAAEDNGANLVCEAKNLL----ATTPLRAELNLTVLYA 345

  Fly   377 PVVKVSPSAITANTSEIVLLNCEYF-ANPASLTQVEWYRNDILVNVN----DTTHYK------GG 430
            |.......|..|...:.|.|:|... :||.:  ::.|       ::|    |.:.||      ||
  Fly   346 PKDVYLSGANQAKVGDSVQLSCVTAPSNPQA--RISW-------SINGRPLDNSTYKTTSSSDGG 401

  Fly   431 --NSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPV----KE 489
              :|.|::|.|.|..:..|.  .|...|.        ::..:|..:.||.:|..|..|:    .:
  Fly   402 WVSSSNISLTIDSQSRTFIA--VCHALNT--------ELTQNVVGSHTVNVLYPPSPPLLTGYND 456

  Fly   490 SD----ESNVTLFCNVLDANPSVLTKVRWYANSTLL---KELPDCEETREDLCHIDPSKLLLESI 547
            .|    .|.:.|.|:....||.  ..::||.|..::   .:|.|.:.|.|       ..||:.:.
  Fly   457 GDILISGSILKLQCSSAGGNPP--PTLQWYKNDKIINAPSKLVDSKITSE-------LSLLVNAS 512

  Fly   548 GRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALSHFP---LVAVKKKSVTFSCSVDDPGF 609
            .....  |.|:..|||...|....|.|.||:.|....:|..|   :..::.|.:..|.|.:.|. 
  Fly   513 DNNAI--YKCKVQNAAIDIPLFATKTLGVHFPPETVKISVVPKNLVPGIRAKLICDSSSSNPPA- 574

  Fly   610 PESNRFRWLRGGRGPLQDIVTKD----WTVEPVGLDSRTN---------YSCYAYNEG-GKGVMA 660
                :..|.:.|. |::.:...:    |......|:...|         |:|.::||. .:.|..
  Fly   575 ----KISWWKDGI-PVEGLNLANRPGLWGGSVSTLEMYVNITQDLDGIVYTCQSHNEVLQRSVHE 634

  Fly   661 TVNLEVHAPPFF----------IKNLPPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERN 715
            |::|::..||.|          ::..|.:..:|.|.....:|          .:|.|||:||..|
  Fly   635 TISLDILYPPKFETPQSTTFVGVEGAPFHVELLASGNPMVIT----------YTWTKDGLPISSN 689

  Fly   716 DSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIEADNAN----YSCVSTGNIVGGSI 776
            .   ...::.:...|                      :.||...:.|    |.|.:..:  .|:.
  Fly   690 S---LSGQRLISDGP----------------------RLNISRLSRNDAGVYICEALNS--QGTA 727

  Fly   777 RSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANP-EPSY-KWI-----FKNETIA--- 831
            .......:||||..|.|||...:|..:  |..:.|..:|.| |.:: :|.     ....||:   
  Fly   728 LLEIQVAVEYAPTITAVSEGRSFVAGE--PAVLACHIQARPLEAAHVRWSRDGYDLATRTISSFE 790

  Fly   832 NGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTV-IKVQFKPRCEIERQ--------EIDDQDT 887
            ||.||:...::.|:|.|.:||:..|:.|:..|:.| :.||..|  ||:..        .:..:..
  Fly   791 NGTALLQIASVERSDIGNFTCIVDNQRGAPAAQNVLLVVQTAP--EIDHSPGFTRYAARLGVRAQ 853

  Fly   888 LICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYA--ISRT-------YRC 943
            |||.:..:| :..|.|   ..:..|..:....|..|||:....|..:.|  |..|       |.|
  Fly   854 LICRSLASP-QPSFIW---RRHGKDLKMQRRNKFKSVERQVDALNFESALLIENTSPDDYGQYEC 914

  Fly   944 VANNTVGYGPFCEIEVAE--------QLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICR 1000
            |..|::|... ..:|.::        ||....:.:....:.......|.:.|..          |
  Fly   915 VVRNSLGQAS-TTLEFSKPSRPDAPLQLRVGNVSDTGVDLNWTPGFDGGMQTYF----------R 968

  Fly  1001 RRRRQ---DKYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPR 1062
            .|.:|   |||              ..:|.....:|:|...                        
  Fly   969 LRLKQHGEDKY--------------KYVDAKPGHQNISLDG------------------------ 995

  Fly  1063 WPIRPGVMLHVSSNTKENLTVNRMTVKPNVSGNRGDMSQLSAQLSAALNGSRDNSDGTILTEISA 1127
              ::||...:.|            .:..|.:|....|..:...||   .||:.:|        :.
  Fly   996 --LKPGATYYFS------------VMAANEAGGSKFMPDIKLTLS---KGSQPHS--------AE 1035

  Fly  1128 VSGENEASNLSILEVTNRKKATVPSTIRNVSTAEGEII--SSKTHSAGHIALDHVWSLIFKKSDD 1190
            .:.::|..|:.|:.:|:   |.:...:.|.:.....:|  .:|:.|....:.|.|:|     .||
  Fly  1036 YTEKDELPNVMIIGITS---AAMVLLVLNAALVAWFVIRRQNKSQSEAEPSNDDVYS-----KDD 1092

  Fly  1191 RTRDSQRSHVGLLQTFWRGLGAKESTSGFESQHRLKGIRCSGSVTYKKAKET--------VHSTS 1247
            .                            :|.::|........|..|.|..|        :.||:
  Fly  1093 S----------------------------QSVYKLPITALQADVQKKAAASTYLVENVDIIQSTA 1129

  Fly  1248 DAASNGESSLTKRPNN-CQPSVSIQLQSNMEEKTSKFVLKDERNNSSTEVENIPCN--------- 1302
            ......|||:...|.. |.|..:..|.:....        .:||:::..:|.:...         
  Fly  1130 YPPKYQESSMCTPPYPLCNPDFTRTLPNPKRH--------SQRNSATGMIEGMQMRSKDDHMLIS 1186

  Fly  1303 ---MVPS-------ITRGSSIESPQRPAP 1321
               .:||       :.:||.|.||. |||
  Fly  1187 NGLYIPSPSPASSLVIKGSYISSPS-PAP 1214

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nrmNP_001246890.1 Ig 44..152 CDD:299845 28/118 (24%)
Ig 176..248 CDD:299845 22/87 (25%)
Ig 277..354 CDD:299845 22/79 (28%)
IG_like 383..463 CDD:214653 22/92 (24%)
Ig 394..463 CDD:143165 20/81 (25%)
Ig_3 585..652 CDD:290638 14/82 (17%)
Ig 685..>719 CDD:299845 9/33 (27%)
IG_like 788..869 CDD:214653 27/91 (30%)
Ig <811..869 CDD:299845 20/68 (29%)
hbsNP_001286439.1 Ig 44..122 CDD:299845 24/90 (27%)
IG_like 45..137 CDD:214653 25/104 (24%)
Ig 153..231 CDD:299845 23/98 (23%)
IG_like 258..342 CDD:214653 26/101 (26%)
Ig 266..327 CDD:299845 22/74 (30%)
IG_like 357..>414 CDD:214653 17/65 (26%)
Ig 360..427 CDD:299845 19/77 (25%)
Ig <468..526 CDD:299845 16/68 (24%)
I-set 547..633 CDD:254352 16/91 (18%)
Ig 556..631 CDD:299845 14/80 (18%)
I-set 644..735 CDD:254352 20/127 (16%)
IGc2 668..725 CDD:197706 15/93 (16%)
IG_like 751..829 CDD:214653 22/79 (28%)
IGc2 753..815 CDD:197706 17/63 (27%)
Ig 852..928 CDD:143165 20/80 (25%)
FN3 935..1017 CDD:238020 18/143 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3515
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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