DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and side-III

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001036681.1	Gene:	side-III / 4379844	FlyBaseID:	FBgn0083949	Length:	1689	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	143/637 - (22%)
Similarity:	246/637 - (38%)	Gaps:	137/637 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALRQSAKDVAKSNCVAVRSSISLSLVLVLCLALVDSSTAQVD--------TTISQQE--SQSVVL 59
            |.|.|...:..|....:|.|......|.|..|.:..::.|:|        :|::.:.  .::..|
  Fly     5 AKRTSTMPLTTSYNANIRRSCLALFALFLFAAHISLTSGQIDWDDDDDPVSTVAVEAVLGRTASL 69

  Fly    60 PCPVDAE-KCGKLHSLNWF-------------KGDDRIAAMLLGDSNVTSVNKEFDERV--TVEQ 108
            ||.::.| |..:::.:.||             :|.....|:...|:|      .|..|.  ...|
  Fly    70 PCDIEPEAKDDRVYMVLWFRESAGKPLYSFDVRGRPFEKALYWSDTN------SFGPRAYFVTGQ 128

  Fly   109 NPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSV 173
            .|.:|.:.::::.||.:|.|...|    :.....| :||.|.|:|||.::::.||.|..:  ...
  Fly   129 QPAKLSVDNIQLDDEGVYRCRVDF----QNSPTRN-HRINLTVIVPPHQILVYDASGRDV--AGA 186

  Fly   174 VGPMQERQSLKATCTVRNTRPQPEVSWFRGTKRLTTYSPT----HDLVDGLYTSTLELDWTLSRE 234
            |||:.|..::..||.||..||:|.|:|..||:.|...|..    |..|:.|..:      .:||.
  Fly   187 VGPLLEGDNIVLTCEVRGGRPEPTVTWMNGTRTLEAGSGVSMGRHVTVNRLEVA------QISRS 245

  Fly   235 DLAQDIECRVKSAAIQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLT 299
            .|.....|:..:..:.........:::.::|||:::..........::..|||.:.|:.|...:.
  Fly   246 ALNNTYRCQASNTKLVAPVERSIRIEMLLKPTSVNLTNKLKVFASNTQYNLTCIVAGSVPDTEIK 310

  Fly   300 WYNTTTIISSGENEITEVRSKSLEKSDG------TFHTQSELIFNATRFENDRVFRCEAENIVLQ 358
            |.........|        ..|..:|:|      ||:.|.|        ::..:.:||..|..||
  Fly   311 WTQNNRPFKRG--------LLSTSQSNGRVISTLTFYPQPE--------DDGTMLKCEGSNPRLQ 359

  Fly   359 INREKPISSALTLEVLYPPVVKVSPSAITANTSEI-----VLLNCEYFANPAS-----------L 407
               ...|..:|.:.|:|||.|.:|..: |....:|     |...|...:||..           :
  Fly   360 ---NSAIEDSLMMNVIYPPQVTLSLGS-TLRPDDIKEGDDVYFECHIKSNPKEHRIMWSHDGQPV 420

  Fly   408 TQ-VEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDV 471
            || |.|   .|:::..             :||::...:...|.|:|..:|:.|: |....:||.:
  Fly   421 TQNVSW---GIIISTR-------------SLVLQRVGRIHSGFYACSAANDRGE-TQSAPVNLRI 468

  Fly   472 QYAPTVEILMIPEGPVKESDESNVTLFCNVLDANPSVLTKVRW---------------YA----- 516
            :|||......|.  .:..|.|.:|.:.|.|....|.:  ...|               ||
  Fly   469 RYAPVCSSSSIT--VIGASLEEDVPIPCRVNSDPPEI--DFEWTFSTSGEHFEVPSGHYATIQDP 529

  Fly   517 ----NSTLLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAG 564
                .|.:.:.:.:..||..:......|:|:....|...:...:|.|.||.|
  Fly   530 TMTTTSDVRRTVVESNETHFESYVETVSELIYTPKGERDYGTLACYGRNAIG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	28/133 (21%)
		Ig	176..248	CDD:299845	22/75 (29%)
		Ig	277..354	CDD:299845	16/82 (20%)
		IG_like	383..463	CDD:214653	18/96 (19%)
		Ig	394..463	CDD:143165	16/80 (20%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
side-III	NP_001036681.1	IG_like	59..166	CDD:214653	25/117 (21%)
		V-set	59..166	CDD:284989	25/117 (21%)
		ig	190..268	CDD:278476	21/83 (25%)
		IG_like	192..259	CDD:214653	21/72 (29%)
		Ig	296..361	CDD:299845	19/83 (23%)
		IG_like	391..468	CDD:214653	19/93 (20%)
		IGc2	392..454	CDD:197706	14/77 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810