DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and side

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	1075	Identity:	221/1075 - (20%)
Similarity:	348/1075 - (32%)	Gaps:	363/1075 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SISLSLVLVLCLALVDSSTAQVDTTISQQE----------SQSVVLPC---PVDAEKCGKLHSLN 75
            ::..:|||:.||..:.|.:|..::...|:.          .::|.|||   |..::...||  |.
  Fly    65 AVGFTLVLLTCLQQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKL--LL 127

  Fly    76 WFKGDDRIAAMLLGDS---NV-----TSVNKEFDERV--TVEQNP--YRLVIKDLKIADEDIYLC 128
            |||....|....| ||   ||     .::..:..:|:  ::..||  .||.|.|:|..|..:|.|
  Fly   128 WFKDTTGIPLYSL-DSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRC 191

  Fly   129 DTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTR 193
            ...||  .....||   |..|.::|||.|..|.||:|..|  ..:.||.:|...|...|.||..|
  Fly   192 RVDFF--NSPTRNF---RHNLTLVVPPEEPRIFDAQGKEI--SQMAGPFREGYELFLCCQVRGGR 249

  Fly   194 PQPEVSWFR------GTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNV 252
            |.|:|:|:|      ||...:.......:|:.|...|...|:...|      ||||.:...:.:.
  Fly   250 PPPKVTWWRDDTELIGTSHTSVEEGATVMVNQLLIGTTTRDFYGIR------IECRAQGTRLVDP 308

  Fly   253 TVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWYNTTTIISSGENEITEV 317
            .....:|.:.::|..:.|.........|..:.:.|:..|:.||..:||      :..||
  Fly   309 VRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYPAAKITW------LLDGE------ 361

  Fly   318 RSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVS 382
               .:..::.|.|:..|
  Fly   362 ---PIRNAEVTVHSDKE------------------------------------------------ 375

  Fly   383 PSAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKEDI 447
                                                          .||.....|.:|.|.:.|.
  Fly   376 ----------------------------------------------DGNITTSILTLKVTSENDN 394

  Fly   448 GNYSCQLSNN--IGKGTSDQKINLDVQYAPTVEILMIPEGP---VKESDESNVTLFCNVLDANPS 507
            ...:|:.:|.  .|....|::| :.|.|.|||.:.:..|.|   |..::..|||..|.. ||.|.
  Fly   395 AELTCRATNPWFSGGAIEDKRI-IRVAYPPTVSVHLANEDPSRLVTRAEGQNVTFKCRA-DARPP 457

  Fly   508 VLTKVRWYANSTLLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDK 572
            | |...|:.|...:..    |.|  ::.|:  ::|..||.|.     |:|...|..| ..||...
  Fly   458 V-TSYSWFKNGMRMSG----EST--EIMHL--TQLERESAGA-----YACGATNTEG-ETRSSSL 507

  Fly   573 ELLVHYEPG-PAALSHFPLVAVKKKSVTFSCSVD-DPGFPESNRFRWLRGGRGPLQDIVTKDWTV 635
            .|.|.:.|. .:......:.||...|:...|.|| ||  |:|.||.|.......:..::..  .:
  Fly   508 TLKVQFSPRCKSGTEQTSIGAVSLHSILVKCEVDADP--PDSVRFSWTYNNTRNVSPVLNS--RI 568

  Fly   636 EPVGLDSRTNY-----------SCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSPNA 689
            :..||.|...|           :|:|.|..|:          ...|..:..||..|      |.|
  Fly   569 QSNGLASTVTYLPQTDSELITLACWASNAVGR----------QTTPCLVHILPANT------PEA 617

  Fly   690 TLTCRIE--------CVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNM 746
            ...|.:.        ||...|     .|:      |:||:.|
  Fly   618 PKACELRNDTVLEVVCVAGSD-----GGL------SQYFMLE----------------------- 648

  Fly   747 PNWPDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVIC 811
                     :...:..||    |:..|.:.:.|..|.     |...:.:|.:....|......|.
  Fly   649 ---------VVGGDPLYS----GDPGGSAGQGRGQFS-----EAIGLGDNEISTLNDQATSAPIF 695

  Fly   812 KSRANPEPSYKWIFKNETIANGNALIINTAMNRNDDG-TYTCLAY--NKHGSSIAKTVIKVQFKP 873
            :.:.| .|.::                   :|..:.| .|..|.|  |..|.|          :|
  Fly   696 RMQEN-SPQFR-------------------LNNLEPGREYQFLVYAVNAKGRS----------EP 730

  Fly   874 RCEIERQEIDDQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAIS 938
            ...||...:        .|...|.:........|..||..:.|.|...:.....   |.|
  Fly   731 PVVIENVRV--------AAQLGPYDESILSEDPTPAETTHHGGGGVGGSGSSSG---LGT----- 779

  Fly   939 RTYRCVANNTVGYGPFCEIEVAEQLAWWQLWEKNTLIILVAA--ILGLLLTVIVICCIIICICRR 1001
                   ..:.|.||                ||.:.::::||  ::|.::...:|...|:.:||.
  Fly   780 -------GASTGSGP----------------EKQSTLLILAAVVVIGAVVVTSIIVAGIVVVCRH 821

  Fly  1002 RRRQDK------------------YLTEVPINSIQ 1018
            |.|..:                  |:.|..:|.::
  Fly   822 RPRPPEPQEVRKSMRPARNDVPSMYIEEDELNELE 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	35/132 (27%)
		Ig	176..248	CDD:299845	23/77 (30%)
		Ig	277..354	CDD:299845	12/76 (16%)
		IG_like	383..463	CDD:214653	9/81 (11%)
		Ig	394..463	CDD:143165	9/70 (13%)
		Ig_3	585..652	CDD:290638	19/78 (24%)
		Ig	685..>719	CDD:299845	8/41 (20%)
		IG_like	788..869	CDD:214653	14/83 (17%)
		Ig	<811..869	CDD:299845	10/60 (17%)
side	NP_001247334.1	V-set	95..211	CDD:284989	34/123 (28%)
		IG_like	100..211	CDD:214653	34/118 (29%)
		Ig	235..301	CDD:299845	22/71 (31%)
		Ig	326..408	CDD:299845	21/190 (11%)
		IG_like	329..407	CDD:214653	20/186 (11%)
		IG_like	435..511	CDD:214653	26/91 (29%)
		Ig_2	442..511	CDD:290606	25/84 (30%)
		FN3	<700..735	CDD:238020	11/64 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810