DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and side-IV

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001034052.2	Gene:	side-IV / 41657	FlyBaseID:	FBgn0038156	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	1011	Identity:	222/1011 - (21%)
Similarity:	364/1011 - (36%)	Gaps:	232/1011 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ISLSLVLVLCLALV--DSSTAQVD-----TTISQQESQSVVLPCPVD-AEKCGKLHSLNWFK-GD 80
            :.||.:..:|...|  |.....:|     ||:.....:..:|||.:. .|:...::.:.||: ||
  Fly    50 LMLSGISQVCSTYVEQDELMQNLDRPVPLTTVQGVLGRQAMLPCDISPQERDDAVYMVLWFREGD 114

  Fly    81 DR------IAAMLLGDSNVTSVNKEFDERV--TVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEE 137
            ..      :.....|.:.:.|....|..|.  :...:|.:|.|.:::|.||.:|.|...|
  Fly   115 GEPIYNFDVRGRQFGQARLWSSPTAFGTRAHFSSTTHPAQLKIDNIRIEDEGVYRCRVDF----- 174

  Fly   138 TCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR 202
            ........:|.|.|:|||...||...  :|.:....|....|...:..:|.|...||:|.|:|:.
  Fly   175 RNSPTRNLKINLTVIVPPDRPVIYGQ--NRHEKAGNVESFSEGNDIVLSCEVSGGRPRPNVTWYL 237

  Fly   203 GTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTVTKFSV---DLQVR 264
            ....:.  .......||...:.|... .:.|:.|...:.|   .|:..|:|.....|   |:.::
  Fly   238 DNTAID--ESFEQRPDGKTINHLSYP-NVGRQHLNSRLMC---VASNTNLTPPNNRVVILDVNLK 296

  Fly   265 PTSIDINGVKHHTVQGSKVV-LTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGT 328
            |.::.|. .|...|...:.. :.|...|::|...:||:       .|..::.:: :|:..:.|.
  Fly   297 PIAVHIL-TKDRFVSADRTYDVECKSSGSKPPALITWW-------KGSKQLKKL-TKNFNEPDN- 351

  Fly   329 FHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPP--VVKVSPSAITANTS 391
             .:.|.|.|...|.::.:...|.|||   |......|.....|.|.|.|  .:|:..|   .|..
  Fly   352 -QSLSILTFTPGREDDGKYLTCRAEN---QFIDGSAIEDKWRLIVHYQPTTTLKIGSS---LNPD 409

  Fly   392 EI-----VLLNCEYFANPASLTQVEWYRN--DILVNVNDTTHYKGGNSENVALVIKSTEKEDIGN 449
            :|     ....|...|||... ::.|:.|  ::..|::     .|....:.:||::|..:...|:
  Fly   410 DIKEGDDAYFECIVLANPKPY-KMSWFHNGKELQHNIS-----AGVILSDQSLVLQSVSRASAGD 468

  Fly   450 YSCQLSNNIGKGTSDQKINLDVQYAPTV-----EILMIPEGPVKESDESNVTLFCNVLDANPSVL 509
            |:|...|:.|||.|: .:.|.::|||..     |:|    |.:|   ...:.|.|.| |::|..
  Fly   469 YTCLAVNSEGKGPSN-PVTLRIRYAPICATDHEELL----GALK---HETLPLKCEV-DSSPPA- 523

  Fly   510 TKVRWYANST-LLKELP---DCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSE 570
            ...:|..||: ...|||   ...||.....:..||..|       .:...||...|:.|
  Fly   524 DSFQWTFNSSGEQTELPARLHSSETGMSRLNYTPSTDL-------DYGTISCWAKNSIG------ 575

  Fly   571 DKELLVHYEPGP------AALSHFPL--VAVKKKSVTFSCSVD-----DPGFP--------ESNR 614
                   .:..|      ||...|||  .:|..:||. |..||     |.|.|        |.|.
  Fly   576 -------TQKSPCVFQIVAAGRPFPLQNCSVTNQSVD-SLQVDCLEGFDGGLPQGFMLELVELNT 632

  Fly   615 FRWLRGGRGPLQDIVTKDWTVEPV-----GLDSRTNYS--CYAYNEGG------------KGVM- 659
            .|..|.        :|...|  ||     .||....|.  .:|.|..|            |||.
  Fly   633 LRLARN--------ITVSHT--PVTFVIDNLDQAATYRMVIFAVNAKGRSEPTIIDDINFKGVAK 687

  Fly   660 ---ATVNLEVHAPPFFIKNLPPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERNDSRYFI 721
               |:..|.:...| |:..|..:.|:|.:         |.|:....|..:   :...|:||...:
  Fly   688 FTGASTGLSMPLSP-FLAGLTLFCGLLFA---------IFCIMLAAIYRR---ISNRRSDSNLKV 739

  Fly   722 KEKYMDASPATGDFESMLSVLH---------FNMPNWPDSKFNIEADNANYSCVSTGNIVG---- 773
            .:......||    :..|..||         .:.|:......|.:..|| ..|.:.|::.|
  Fly   740 AKHTQLTIPA----DCQLDPLHPGVQTDGSGNHQPHHSLLPLNCDGRNA-VDCGALGDVGGGGVG 799

  Fly   774 ----GSIRSRTYFGIEYAPENTTVSE------------NIVYVQEDTIPGRV---ICKSRANP-- 817
                |.|:..:..|:...|.:|..|.            :|.....|.||.:.   ..||..:|
  Fly   800 VGLDGGIKGSSPIGLVAMPGDTLRSNARNRHSPMADQADIDDTDPDVIPNQYEKRPLKSLVSPPG 864

  Fly   818 --EPSYK-----WIFKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKPRC 875
              .||.:     ::.:.|....|:.:.:..|...:..|..         ||....|:...|:|..
  Fly   865 FASPSNRLMQRDYLRETELTKGGSDVGMGAAEGLSSIGLM---------SSSGNEVLHYTFRPSK 920

  Fly   876 EIERQEIDDQDTLICTAYGNPIEADFSWSIKTENET 911
            :|....::.:....|    :|.....::|:.|...|
  Fly   921 QISYATLNKKGITTC----SPPLGSLNYSVSTSTPT 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	26/122 (21%)
		Ig	176..248	CDD:299845	14/71 (20%)
		Ig	277..354	CDD:299845	15/77 (19%)
		IG_like	383..463	CDD:214653	21/86 (24%)
		Ig	394..463	CDD:143165	18/70 (26%)
		Ig_3	585..652	CDD:290638	24/88 (27%)
		Ig	685..>719	CDD:299845	6/33 (18%)
		IG_like	788..869	CDD:214653	19/104 (18%)
		Ig	<811..869	CDD:299845	12/66 (18%)
side-IV	NP_001034052.2	V-set	79..188	CDD:284989	25/113 (22%)
		IG_like	80..188	CDD:214653	24/112 (21%)
		Ig	210..281	CDD:299845	15/76 (20%)
		Ig	319..392	CDD:299845	19/85 (22%)
		IG_like	319..383	CDD:214653	17/76 (22%)
		IG_like	412..489	CDD:214653	20/83 (24%)
		IGc2	413..478	CDD:197706	15/70 (21%)
		Ig_3	509..572	CDD:290638	18/71 (25%)
		fn3	593..675	CDD:278470	25/92 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810