DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and side-VII

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	705	Identity:	163/705 - (23%)
Similarity:	268/705 - (38%)	Gaps:	148/705 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 ISLSLVLVLCLALVDSSTAQVDTTISQQES---QSVVLPCPVDAEKCGKLHSLNWFKGDDRIAAM 86
            :.|.|:.:|.|.|::||....|..|.|.||   :::.|||.|..           :.||:.:..:
  Fly     1 MELLLLFMLALQLIESSIGSKDVPIHQIESIVGENIYLPCNVTT-----------YDGDEPVLVL 54

  Fly    87 LLGDSNVTSV------------------NKEFDERV--TVEQNPYRLVIKDLKIADEDIYLCDTT 131
            ...|...|.:                  :..|.:|.  ..::.|.:|.|::.:.:|...|.|...
  Fly    55 WYRDDKGTPIYSIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPGKLSIQNTQASDSGTYRCRVD 119

  Fly   132 FFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQP 196
             |:..:|.::    ||.|.|:.||.:|:|.|:  ..::..:||||..|...:...|.|....|.|
  Fly   120 -FLKAQTINS----RIRLNVISPPKQVIIRDS--SNVERSTVVGPYSEGDIVSLKCQVIGGYPTP 177

  Fly   197 EVSWFRGTKRLTTYSPTHDLVDGLYT----------STLELDWT---LSREDLAQDIECRVKSAA 248
            .:||:|               ||:..          ..:|.:.|   |.||||...:.||..|..
  Fly   178 TISWYR---------------DGIEIPCELSHLAGGKIIECEITLPSLGREDLNSRLTCRALSHP 227

  Fly   249 IQNVTVTKFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWY-------NTTTI 306
            ...:......:|:...|.:|.:.|.......|.:..|.|...|:||...:||:       .||..
  Fly   228 RAPIVEAVVQIDMNFAPLNIRLLGAHQPLSAGRRYDLLCQSAGSRPPAVITWWQNGIRLEKTTET 292

  Fly   307 ISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTL 371
            .||..|:.|...|.||.|||.                 .:...|:|.|..:.   .:|:.....|
  Fly   293 TSSDGNQTTSTLSISLSKSDA-----------------GKYLSCKAYNHAVP---SEPLEDGWKL 337

  Fly   372 EVLYPPVVKV------SPSAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGG 430
            ::.|.|...|      .||.:...|.  |..:|...|:| ::.::||..|:..::.|.:.   |.
  Fly   338 DIQYVPEAYVRLGTSLDPSTLREGTD--VYFDCLVMAHP-NVFRIEWRHNEQPLSHNISL---GV 396

  Fly   431 NSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYAPT-VEILMIPEGPVKESDESN 494
            ...|.:||::...:...|||||...|..|:|.| ....|::.|||| .:......|..|:.|
  Fly   397 IISNHSLVLQGVTRATAGNYSCVGFNAEGEGIS-APFALNILYAPTCAQNQKKVYGIAKQED--- 457

  Fly   495 VTLFCNVLDANPSVLTKVRWYANST----------LLKELPDCEETREDLCHIDPSKLLLESIGR 549
            ..:.|.| ||||..: :..|..|::          :::.......|...:..:|...||
  Fly   458 AKVMCTV-DANPREV-EFSWTFNNSAESIDVATNHIIRSGTTSIVTYTPITELDYGTLL------ 514

  Fly   550 GFFYNYSCEGFNAAGWGPRSEDKELLVHYEPG--PAALSHFPLVAVKKKSVTFSCSVD-DPGFPE 611
                   |...|..|    .:....:.|....  |..:.:..:..:...|:|.:||.. :.|.|:
  Fly   515 -------CLASNKIG----KQRVPCVFHIIAAGRPEKVHNCTVNNISMTSLTVTCSDGFNGGLPQ 568

  Fly   612 SNRFRWLRGGRGPLQDIVTK---DWTVEPVGLDSRTNYSCYAYNEGGKGVMATVN 663
            |.....|......::..:|.   .:||..:...|....:.||:|..|:...|.||
  Fly   569 SFNLELLDSYTQEIKANITSTIPKFTVPGLSPGSIYRLNIYAFNTKGRSDPAIVN 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	26/130 (20%)
		Ig	176..248	CDD:299845	21/84 (25%)
		Ig	277..354	CDD:299845	22/83 (27%)
		IG_like	383..463	CDD:214653	23/79 (29%)
		Ig	394..463	CDD:143165	20/68 (29%)
		Ig_3	585..652	CDD:290638	14/70 (20%)
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	21/117 (18%)
		V-set	32..134	CDD:284989	21/117 (18%)
		IGc2	160..>214	CDD:197706	14/68 (21%)
		Ig	262..328	CDD:299845	22/85 (26%)
		IG_like	264..323	CDD:214653	21/75 (28%)
		IGc2	360..425	CDD:197706	19/70 (27%)
		Ig_3	456..519	CDD:290638	14/80 (18%)
		FN3	538..620	CDD:238020	17/81 (21%)
		FAM176	643..741	CDD:291517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810