DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and ed

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001260013.1	Gene:	ed / 33619	FlyBaseID:	FBgn0000547	Length:	1332	Species:	Drosophila melanogaster

Alignment Length:	1619	Identity:	314/1619 - (19%)
Similarity:	547/1619 - (33%)	Gaps:	478/1619 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QSAKDVAKSNCVAVRSSISLSLVLVLCLALVDSSTAQVDTTISQQESQSVVLPCPVDAEKCGKLH 72
            :||:..|.:.|         :..|:..:||  |||...|.:|..:|:..:.|.|..:.:......
  Fly    16 RSARRAATTIC---------NFFLIALVAL--SSTTLADESIDTRENADLTLKCRFNDKYEANDF 69

  Fly    73 SLNWFKGDDRIAAMLLGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEE 137
            |..|              :..|:...:||          .:.|.:::::
  Fly    70 SFFW--------------TRWTANPAQFD----------NVAIGEVQLS---------------- 94

  Fly   138 TCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPEVSWFR 202
                 :|||::.                                             |||    |
  Fly    95 -----SGYRLDF---------------------------------------------QPE----R 105

  Fly   203 GTKRLTTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAA--------IQNVTVTKFSV 259
            |...|...:.:::..:|.:                   |||:|:..        ..|:||.....
  Fly   106 GIYDLQIKNVSYNRDNGRF-------------------ECRIKAKGTGADVHQEFHNLTVLTPPH 151

  Fly   260 DLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNLTWY----NT---TTIISSGENEITEV 317
            ...:.|.:|.:      ..:...:.|||...|..|...:|||    ||   .|::..|..:..
  Fly   152 PPVISPGNIAV------ATEDKPMELTCSSIGGSPDPTITWYREGSNTPLPATVLKGGTKDQP-- 208

  Fly   318 RSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVS 382
                         |.:.|.....|.::...::|...|..:  |..|.:.:..||.|.|.|.|:|.
  Fly   209 -------------TNATLSIIPRREDDGAKYKCVVRNRAM--NEGKRLEATATLNVNYYPRVEVG 258

  Fly   383 P-SAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSENVALVIKSTEKED 446
            | :.:.........|.|...|.| .:..|.|.||...:            |.::...|.....:|
  Fly   259 PENPLRVERDRTAKLECNVDAKP-KVPNVRWNRNGRFI------------SSSLVHTIHRVSVQD 310

  Fly   447 IGNYSCQLSNNIGKGTSDQKINLDVQYAPTVEILMIPEGPVKESDESN-VTLFCNVLDANPSVLT 510
            .|.|:|...|.:|| |.:|::.||:.|.|.|.|    |...:|::|.: ||:.||| .|||:.:|
  Fly   311 AGKYTCIADNGLGK-TGEQELILDILYPPMVVI----ESKTREAEEGDTVTIRCNV-TANPAPVT 369

  Fly   511 KVRWYANSTLLKE-LPDCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKE- 573
             :.|      ||| .||        ...:...|.|.|:......||.|...|..    :|:..|
  Fly   370 -IEW------LKENSPD--------FRYNGDVLTLTSVRADHAGNYICRAVNIM----QSQGMER 415

  Fly   574 ----------LLVHYEPGPAALS-HFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLR---GGRGP 624
                      |||.:.||.|.:: :.|:|.| ...||.:||.:.||:|.. ::||.|   |....
  Fly   416 SERVGNSTVALLVRHRPGQAYITPNKPVVHV-GNGVTLTCSANPPGWPVP-QYRWFRDMDGEFSS 478

  Fly   625 LQDIVTK--DWTVEPVGLDSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKNLPPYTGILHSSP 687
            .|.|:.:  .:::....|.:...|.|:|.||.|.|:|||:.||:|.||.|:..|..:.....:..
  Fly   479 TQKILAQGPQYSIPKAHLGNEGKYHCHAVNELGIGMMATIVLEIHQPPQFLAKLQQHMTRRVADT 543

  Fly   688 NATLTCRIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSV---LHFNMPNW 749
            :.|:||..:..|...:.|.||.|.|...::.|.::     .:|..| ...|::|   |.|.....
  Fly   544 DYTVTCSAKGKPAPSVKWLKDAVEILPEENLYEVQ-----TNPDQG-LNGMVTVQSQLKFRGKAR 602

  Fly   750 PDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSR 814
            |:....:..|...|:|:....:  .|..|.....||:.|........:.:...:|  ..|:||.:
  Fly   603 PNGNALVPGDRGLYTCLYQNEV--NSANSSMQLRIEHEPIVLHQYNKVAFDIRET--AEVVCKVQ 663

  Fly   815 ANPEPSYKWIFKNE----TIANGNALIINTAMNRN---------------DDGTYTCLAYNK--- 857
            |.|:|.::|.|.|.    |:::.....|:|..:.|               |.|.|||...|.
  Fly   664 AYPKPEFQWQFGNNPSPLTMSSDGHYEISTTTDNNDIYTSVLKINSLTHSDYGEYTCRVANTLDT 728

  Fly   858 -------------------------HG-----------SSIAKTVIKVQFK----PRCEIERQEI 882
                                     |.           ..::||...|.::    ||   |.|.|
  Fly   729 IRAPIRLQQKGPPEKPTNLRATEVGHNYVSLSWDPGFDGGLSKTKFFVSYRRVAMPR---EEQLI 790

  Fly   883 DDQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAISRTYRCVANN 947
            .|     |....|   ::.:|.     |.|.......|..::|:     ...||    ::..|.|
  Fly   791 PD-----CATLAN---SNSAWV-----EVDCQRDIPCKVTALEQ-----HQSYA----FKVKALN 833

  Fly   948 TVGYGPF-CEIEVAEQLA-----WWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRRQD 1006
            .....|: .||.|..:::     ....:|.||      ..||  :.|...|..::.:.......|
  Fly   834 PKSDSPYSSEIMVTTKVSRIPPPLQVTYEPNT------RTLG--IDVGATCLNLVAVVESMVNAD 890

  Fly  1007 KYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTAILPNPSSSRFIGSAPKSPPRWPIRPGVML 1071
            ..:....:.:..    |.|.:|  |...:.::|   |:.....:|.:|..           ..:.
  Fly   891 SPMAAWEVVTTM----DNLQLS--GNGPTHKEK---IIDRIIGARRVGGG-----------RALG 935

  Fly  1072 HVSSNTKENLTVNRMTVKPNVSGNRGDMSQLSAQLSAALNGSRDNSDGTILTEISA--VSGENEA 1134
            |..|..:::..:|.:.::        |.:..:.::...|..:.::.......||..  ::..|..
  Fly   936 HTISEDEDDNGLNSLALE--------DENSPTVRVKLCLRTNPEHCGDYTDAEIGRPYIAEANAL 992

  Fly  1135 SNLSILEV---------------------TNRKKATVPSTIRNVSTAEGEIISSKTHSA------ 1172
            :..:::.:                     .|:.|.:..:....:.:....|::::.:.|
  Fly   993 ATPTLIAIIVSCVVFALFAGLILMFCRCKRNQSKKSAAAKDYEMDSVRPSIVAAQQNQAPPPYYP 1057

  Fly  1173 ----GHIALDHVWSLIFKKSDDRTRDSQRSHVGLLQTFWRGLGAKESTSGFESQHRLKGIRCSGS 1233
                .:.||:|...|.....|.:|                .|.|.::...:.....:.|:...|.
  Fly  1058 ASGLDNKALEHSMDLALSMEDQKT----------------ALYATQNGYSYHPGSGVVGVGMGGG 1106

  Fly  1234 VTYKKAKETVHSTSDAASNGESSLTKRPNNCQPSVSIQLQSNMEEKTSKFVLKDERNNSSTEVEN 1298
            |.......:|.|.......|........|.. |.:|.......|.....::   |.|.|::
  Fly  1107 VVGVGVGGSVVSGMGGGVGGIGGSGVGVNGI-PGLSAHTMPGNEWVNMGYM---ENNYSNS---- 1163

  Fly  1299 IPCNMVPSITRGSSIESPQRPAPSSLPLKNFLNVTSWGCSGNSTMVPSHILANEQIHDKSSSLRE 1363
                     ..|.|:.|..    |...:|  ::..:.|........|    .|:.:..:.:...:
  Fly  1164 ---------NNGGSVNSQD----SLWQVK--MSAAAVGNQQGMVQAP----MNQYVEQQPAYGYD 1209

  Fly  1364 PLTEPG-----EYENLPFHGLQTAPNKFSTTPTNFNNNTNAVR---------VAQRPKELIG-NI 1413
            |||..|     :|  .|:..|...|::......|..|:.|..|         ..|:||:.:. ::
  Fly  1210 PLTHGGYGAVDDY--APYPHLTATPSQVGDEYHNLRNSQNPSRQDYCSDPYASVQKPKKRVDQHL 1272

  Fly  1414 NQPSVGLYQDCQATHDPLLYHQKYFCDQDALNDQRSQYTTMHRPPNNVQYNQSLFKPDS 1472
            :.|    |.|.....:|  |:.::....:.|            ||   |.:.||...||
  Fly  1273 DSP----YHDVSGLPNP--YNMEHLEQDEVL------------PP---QQHMSLSYDDS 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	14/107 (13%)
		Ig	176..248	CDD:299845	11/71 (15%)
		Ig	277..354	CDD:299845	16/83 (19%)
		IG_like	383..463	CDD:214653	18/80 (23%)
		Ig	394..463	CDD:143165	17/68 (25%)
		Ig_3	585..652	CDD:290638	20/72 (28%)
		Ig	685..>719	CDD:299845	9/33 (27%)
		IG_like	788..869	CDD:214653	24/138 (17%)
		Ig	<811..869	CDD:299845	21/115 (18%)
ed	NP_001260013.1	Ig	50..147	CDD:299845	25/209 (12%)
		I-set	146..249	CDD:254352	24/125 (19%)
		Ig	168..249	CDD:299845	21/97 (22%)
		IGc2	268..323	CDD:197706	15/67 (22%)
		Ig_3	341..406	CDD:290638	25/84 (30%)
		Ig_2	437..514	CDD:290606	23/78 (29%)
		I-set	526..633	CDD:254352	25/114 (22%)
		Ig	546..632	CDD:143165	22/93 (24%)
		IG_like	654..736	CDD:214653	20/83 (24%)
		Ig	656..734	CDD:143165	19/77 (25%)
		FN3	741..848	CDD:238020	25/131 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810