DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and Psg16

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	XP_030098466.1	Gene:	Psg16 / 26436	MGIID:	1347249	Length:	477	Species:	Mus musculus

Alignment Length:	502	Identity:	99/502 - (19%)
Similarity:	190/502 - (37%)	Gaps:	108/502 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSLVLVLCLALVDSSTAQV---DTTISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDRIAAMLL 88
            |:..|:.|..|  |:||||   ....:..|.::|:|......|   .|.:|.|::|..:|....|
Mouse    26 LAASLLACWLL--STTAQVTIESVPFNVVEGENVLLRVDNLPE---NLITLAWYRGLRKIVVYTL 85

  Fly    89 GDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLV 153
             ::.|:.:.:.:..|..|..|. .|.|.::...|..:|...|.....|....:|....:...:.:
Mouse    86 -NTKVSVMGQMYSGREIVSSNG-SLWIHNVTRKDTGLYTLRTVNRRGEIVSTSFTFLYVYTSLFI 148

  Fly   154 ---P--PTEVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQPE-VSWFRG--------- 203
               |  |.::.|........:.|||:            ..|.|.:.:.. :||::|
Mouse   149 CGRPSFPAKLTIESVPPSVAEGGSVL------------LRVHNLQDKLRGLSWYKGAHVSRNLEI 201

  Fly   204 -----TKRLTTYSPTHDLVDGLYTSTLELDWTLSRED--------LAQDIECRVKSAAIQNVTVT 255
                 .|..:...|.|...:.:|::...|...::|.|        |::..:..:....:|..|..
Mouse   202 ARQIIAKNSSVPGPAHSGRETVYSNGSLLLQNVTRNDTGFYTLQTLSRHRKMELAHVQLQVDTSL 266

  Fly   256 KFSVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARPAVNL-------TWYNTTTII------ 307
            ....| .:..|.:.|:.:..:..:|..::|.        .:||       .||....|.
Mouse   267 SSCCD-TLDSTQLIIDPMPRYAAEGESILLR--------VLNLPEDFQVFCWYKGALIFQIFKIA 322

  Fly   308 --SSGENEITEVRSKSLEKSDGTFHTQSELIFNATRFEN--------DRVFRCEAENIVLQINRE 362
              |...|.||:..::|  :::..:...|.|:.:.|..:.        ||.|:.|..::.:|:|
Mouse   323 EYSRARNSITKGPAQS--RTERVYTNGSLLLQDVTEKDTGLYTLQTIDRNFKIEKAHVQIQVN-- 383

  Fly   363 KPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQVEWYRNDILVNVNDTTHY 427
            ||::.         |.::|:.|.:...:|  |:..|  |::...:: :.|..|:..:.:.:....
Mouse   384 KPVTQ---------PFMRVTDSTVRVQSS--VVFTC--FSDNTGVS-IHWLFNNQSLQLTERITL 434

  Fly   428 KGGNSENVALVIKSTEKEDIGNYSCQLSNNIGKGTSDQKINLDVQYA 474
            .....:   |.|....|||.|.|.|::.|     .:..|.:|.|..|
Mouse   435 SPSKCQ---LRINPVRKEDGGEYQCEVFN-----LASSKSSLPVSLA 473

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	23/110 (21%)
		Ig	176..248	CDD:299845	13/94 (14%)
		Ig	277..354	CDD:299845	19/99 (19%)
		IG_like	383..463	CDD:214653	16/79 (20%)
		Ig	394..463	CDD:143165	14/68 (21%)
		Ig_3	585..652	CDD:290638
		Ig	685..>719	CDD:299845
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
Psg16	XP_030098466.1	IgV_CEACAM_D1	42..139	CDD:409430	22/101 (22%)
		Ig strand B	57..61	CDD:409430	2/3 (67%)
		Ig strand C	70..74	CDD:409430	1/3 (33%)
		Ig strand E	106..110	CDD:409430	1/4 (25%)
		Ig strand F	120..125	CDD:409430	1/4 (25%)
		Ig strand G	134..137	CDD:409430	0/2 (0%)
		IgV_CEACAM_D1	158..262	CDD:409430	17/115 (15%)
		Ig strand B	173..177	CDD:409430	1/15 (7%)
		Ig strand C	186..190	CDD:409430	1/3 (33%)
		Ig strand E	227..231	CDD:409430	0/3 (0%)
		Ig strand F	241..246	CDD:409430	0/4 (0%)
		Ig strand G	255..258	CDD:409430	0/2 (0%)
		IgV_CEACAM_D1	278..382	CDD:409430	20/113 (18%)
		Ig strand B	293..297	CDD:409430	1/11 (9%)
		Ig strand C	306..310	CDD:409430	0/3 (0%)
		Ig strand E	347..351	CDD:409430	1/3 (33%)
		Ig strand F	361..366	CDD:409430	0/4 (0%)
		Ig strand G	375..378	CDD:409430	0/2 (0%)
		IgI_hCEACAM_2_4_6_like	388..475	CDD:409402	22/108 (20%)
		Ig strand B	404..408	CDD:409402	1/3 (33%)
		Ig strand C	417..421	CDD:409402	1/3 (33%)
		Ig strand E	439..443	CDD:409402	1/6 (17%)
		Ig strand F	453..458	CDD:409402	2/4 (50%)
		Ig strand G	468..471	CDD:409402	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000