DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nrm and Sirpa

DIOPT Version :9

Sequence 1:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster
Sequence 2:XP_006235013.1 Gene:Sirpa / 25528 RGDID:3449 Length:513 Species:Rattus norvegicus


Alignment Length:467 Identity:99/467 - (21%)
Similarity:168/467 - (35%) Gaps:111/467 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 LVLCLALVDS-----------STAQVDTTISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDR-- 82
            |:.||.|..|           ...|.|.::|.....|..|.|.|.:  ...:..:.||||:.:  
  Rat    14 LLFCLLLSASCFCAGASGKELKVTQADKSVSVAAGDSATLNCTVSS--LTPVGPIKWFKGEGQNR 76

  Fly    83 --IAAMLLGD-----SNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTF--FIPEET 138
              |.:.:.|:     :||:...|.       ....:.:.|.::...|...|.| ..|  .|.|..
  Rat    77 SPIYSFIGGEHFPRITNVSDATKR-------NNMDFSICISNVTPEDAGTYYC-VKFQKGIVEPD 133

  Fly   139 CDNFNGYRIELRVLVPPT--EVVILDAKGDRIKNGSVVGPMQERQSLKATCTVRNTRPQP-EVSW 200
            .:..:|....|.||..|:  ||...|::|            ...|::..||......|:. .:.|
  Rat   134 TEIKSGGGTTLYVLAKPSSPEVSGPDSRG------------SPGQTVNFTCKSYGFSPRNITLKW 186

  Fly   201 FRGTKRL----TTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQ----NVTVTKF 257
            .:..|.|    ||.|...::...: :||:.:  .||.||:...:.|.|....::    |.| ..|
  Rat   187 LKDGKELSHLETTISSKSNVSYNI-SSTVSV--KLSPEDIHSRVICEVAHVTLEGRPLNGT-ANF 247

  Fly   258 SVDLQVRPTSIDINGVKHHTVQGSKVVLTCDIHGARP-AVNLTWYNTTTIISSGENEITEVRSKS 321
            |..::|.||   :...:......|:|.|||.:....| |:.|.|      :.:|....|:.....
  Rat   248 SNIIRVSPT---LKITQQPLTPASQVNLTCQVQKFYPKALQLNW------LENGNLSRTDKPEHF 303

  Fly   322 LEKSDGTFHTQSELIFNATRFENDRVFRCEAE--------------------------------- 353
            .:..|||::..|..:.|::....|.||.|:.|                                 
  Rat   304 TDNRDGTYNYTSLFLVNSSAHREDVVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNA 368

  Fly   354 ----NIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQVEWYR 414
                |:.:.:.....:...|.:..||  ::::.......:||...|...|  .|...:|||:...
  Rat   369 YYNWNVFIGVGVACALLVVLLMAALY--LLRIKQKKAKGSTSSTRLHEPE--KNAREITQVQSLI 429

  Fly   415 NDILVNVNDTTH 426
            .| ..::||.|:
  Rat   430 QD-TNDINDITY 440

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nrmNP_001246890.1 Ig 44..152 CDD:299845 25/118 (21%)
Ig 176..248 CDD:299845 18/76 (24%)
Ig 277..354 CDD:299845 21/114 (18%)
IG_like 383..463 CDD:214653 12/44 (27%)
Ig 394..463 CDD:143165 10/33 (30%)
Ig_3 585..652 CDD:290638
Ig 685..>719 CDD:299845
IG_like 788..869 CDD:214653
Ig <811..869 CDD:299845
SirpaXP_006235013.1 V-set 38..147 CDD:284989 25/118 (21%)
IG_like 41..146 CDD:214653 23/114 (20%)
Ig 146..255 CDD:299845 30/124 (24%)
IG_like 158..>222 CDD:214653 16/78 (21%)
IgC 266..344 CDD:143166 21/83 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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