DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and HEPACAM2

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001275733.1	Gene:	HEPACAM2 / 253012	HGNCID:	27364	Length:	485	Species:	Homo sapiens

Alignment Length:	501	Identity:	100/501 - (19%)
Similarity:	164/501 - (32%)	Gaps:	178/501 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   566 GPRSEDKELLVHY---EPG-----------PAALSHFPLVAVKKKSVTFSCSVDDPGFPESNRFR 616
            |.|.:...|.|||   .|.           |..:..:.|.:|.|..|        |.....::|.
Human    66 GVRGQALYLPVHYGFHTPASDIQIIWLFERPHTMPKYLLGSVNKSVV--------PDLEYQHKFT 122

  Fly   617 WLRGGRGPLQDIVTKDWTVEPVGLDSRTNYSCYAYNEGGKG-------VMATVNLEVHAPPFFIK 674
            .:......|         :.|:......|| ....|..|.|       :..||:..|..|   :.
Human   123 MMPPNASLL---------INPLQFPDEGNY-IVKVNIQGNGTLSASQKIQVTVDDPVTKP---VV 174

  Fly   675 NLPPYTGILHSSPNATLTCRIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESML 739
            .:.|.:|.:....|.||||.:|...|....|.|:|.|:.               :.:|..|....
Human   175 QIHPPSGAVEYVGNMTLTCHVEGGTRLAYQWLKNGRPVH---------------TSSTYSFSPQN 224

  Fly   740 SVLHFNMPNWPDSKFNIEADNANYSCV---STGNIVGGSIRSRTYFGIEYAPENTTV-SENIVYV 800
            :.||..    |.:|    .|..||||:   ....:....|....|:|    |....| |:..:.|
Human   225 NTLHIA----PVTK----EDIGNYSCLVRNPVSEMESDIIMPIIYYG----PYGLQVNSDKGLKV 277

  Fly   801 QE-DTIP-GRVI---CKSRANPEPSYKWIFKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGS 860
            .| .|:. |..|   |.:.::|..:|.||                  .|.|:.||..    |||
Human   278 GEVFTVDLGEAILFDCSADSHPPNTYSWI------------------RRTDNTTYII----KHG- 319

  Fly   861 SIAKTVIKVQFKPRCEIERQEIDDQDTL--ICTAYGNPIEADFSWSIKTENETDENLGSGKKENS 923
                        ||.|:..::: .|.|:  :|.||.|.                    :|:::
Human   320 ------------PRLEVASEKV-AQKTMDYVCCAYNNI--------------------TGRQD-- 349

  Fly   924 VEKSFYILQTDYAISRTYRCVANNTVGYGPFCEIEVAEQLAWWQLWEKNTLIILVAAILGLLLTV 988
             |..|.::.|...:                       |:||     :|...:..:|:|.|:.|.:
Human   350 -ETHFTVIITSVGL-----------------------EKLA-----QKGKSLSPLASITGISLFL 385

  Fly   989 IVICCIIIC--------ICRRR---RRQDKYLTEVPINSIQSALSD 1023
            |:..|::..        :.:::   |.:.:|......:..:.||.|
Human   386 IISMCLLFLWKKYQPYKVIKQKLEGRPETEYRKAQTFSGHEDALDD 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845
		Ig	277..354	CDD:299845
		IG_like	383..463	CDD:214653
		Ig	394..463	CDD:143165
		Ig_3	585..652	CDD:290638	10/66 (15%)
		Ig	685..>719	CDD:299845	11/33 (33%)
		IG_like	788..869	CDD:214653	20/86 (23%)
		Ig	<811..869	CDD:299845	12/57 (21%)
HEPACAM2	NP_001275733.1	Ig	128..>197	CDD:299845	18/81 (22%)
		I-set	172..255	CDD:254352	25/108 (23%)
		IGc2	190..249	CDD:197706	21/81 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000