DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and syg-2

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001309674.1	Gene:	syg-2 / 181561	WormBaseID:	WBGene00007750	Length:	1230	Species:	Caenorhabditis elegans

Alignment Length:	969	Identity:	227/969 - (23%)
Similarity:	348/969 - (35%)	Gaps:	252/969 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 VEQNPYRLVIK--DLKIADEDIYLCDTTFFIPEETCDNFNGYRIELRVLVPPTEVVILDAKGDRI 168
            ::||...|.:|  .:.:.|:..|.|.  ...|||.......:   |.::|||..|..     ...
Worm    80 IKQNAEELHLKITHVNLDDDGEYECQ--MLHPEEGPIRAKSF---LNIIVPPQLVYF-----SNY 134

  Fly   169 KNGSVVGPMQERQSLKATCTVRNTRPQPEVSWF-------RGTKRLTTYSPTHDLVDGLYTS-TL 225
            :..|::. ::|...|..||.|.|.:|:|||.|:       |..|:.:|  |..:....:||| .:
Worm   135 QPNSIIA-VKENTPLNITCVVPNVKPEPEVLWYMDGKVMSRDVKQAST--PHLNKTFTVYTSLVV 196

  Fly   226 ELDWTLSREDLAQDIECRVKSAAIQNVT----VTKFSVDLQVRPTSIDINGVKHHTV--QGSKVV 284
            :.|    |.|..:.|.|.    |.|..|    .|..::|:...|:...:..:::.:.  .|..|.
Worm   197 QSD----RNDHGKVITCE----AFQKETDIRITTNTTLDVLFPPSDPTVEILRNPSALRSGDNVT 253

  Fly   285 LTCDIHGARPAVNLTWYNTTTIISSGENEITEVRSKSLEKSDGTFHTQSELIFNATRF---ENDR 346
            :.|.:.|..|..::.||:        ||       |.|: |..|..|:|:.|.|...|   :||.
Worm   254 IACSVTGGNPPPDVFWYH--------EN-------KRLQ-SHSTLDTRSKEIKNIYSFIASQNDN 302

  Fly   347 V--FRCEAENIVLQINREKPISSALTLEVLYPP--VVKVSPSAITANTSEIVLLNCEYF-ANPAS 406
            :  :.|.|.|    .....|...|:.|||.|||  |.....|.|...:|  ..:.|:.. :||||
Worm   303 MAEYECRANN----SRTGNPKRKAMKLEVNYPPASVELFGESNIRYGSS--ANIQCKSLPSNPAS 361

  Fly   407 LTQVEWYRNDILVNVNDTTHYKGGN----SENVALVIK--STEKEDIGNYSCQLSNNIGKGTSDQ 465
              |:.|..|...|.......:...|    |.||::...  |.|...| |..|..:|..|......
Worm   362 --QITWIINGRSVPTPTQREFVVENGIVSSSNVSVHSNELSVEAHQI-NVECMATNPEGSSAKQH 423

  Fly   466 KINLDVQYAPTVEILMIPEGPV---------KESDESNVTLFCNVLDANPSVLTKVRWYANST-- 519
                      .::|:..|:.|:         .|.|..|||  |.....||  |.::.||..|.
Worm   424 ----------VIKIIAPPKAPIITGLEDRKFFEGDIVNVT--CEAQGGNP--LAELSWYRGSEKH 474

  Fly   520 LLKELPDCEETREDLCHIDPSKLLLESIGRGFFYNYS----------------CEGFNAAGWGPR 568
            |:|.....:.::.:..|.:.:.          |.:||                ||..|||...|.
Worm   475 LVKGRKKMKWSQVNGAHNEVAG----------FSSYSTLALRVDRTMNTQRLKCEATNAALDEPL 529

  Fly   569 SEDKELLVHYEP-----------------GPAA------LSHFPLVAVKKKSVTFSCSVDDPGFP 610
            .|.:.|.|:|.|                 |.:|      ||..|...:   |..||.:.||
Worm   530 IESQYLSVYYPPRRVLIRPADSGDQRLLVGKSARLVCGTLSSNPAAHI---SWQFSRATDD---- 587

  Fly   611 ESNRFRWLRGGRGPLQDI----VTKD--WTVE------PVGLDSRTNYSCYA-YNEGGKGVMATV 662
              |:..        |.|:    .|:|  :.||      |......|...|.| :.|....|..:.
Worm   588 --NKVH--------LGDVSLNETTRDNGFNVENVLSFTPTEEYDGTVVHCIANHPEWKHSVNTSF 642

  Fly   663 NLEVHAPPFFIKNLPPYTGILHSSPNATLTCRIECVPRCDI-SWQKDGVPIERNDSRYFIKEKYM 726
            .|.|..||..:.| .|.|.::....:......:...|...: .|:|:|||.:....|.|
Worm   643 PLNVMYPPKMLVN-DPVTVVMSEGDSFKENLTVRGNPAISLWQWRKNGVPFDHTIGRVF------ 700

  Fly   727 DASPATGDFESMLSVLHFNMPNWPDSKFNIEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENT 791
                |.|   ::||           .|..:..|...|:..:|.::  ||........:||:...|
Worm   701 ----ARG---AVLS-----------GKQLLSTDAGVYTLTATNSV--GSTNITIKLAVEYSARIT 745

  Fly   792 TVSENIVYVQEDTIPGRVICKSRANPEPS----YKWIFKNETIA----NGNALIINTAMNRNDDG 848
            ::|..::....||    |:.:..|:.|||    ..|....|.:|    .....|:.........|
Worm   746 SISTPVIAATGDT----VLLECEADGEPSKANMIHWYKNGEILAAQHRGHKKAILRLNATEQQSG 806

  Fly   849 TYTCLAYNKHG-SSIAKTVIKVQFKPR-CEIERQE-----IDDQDTLICTAYGNPIEADFSWSIK 906
            .|||.|.|..| .:..:|.:.|...|| ..:.|..     :.......|..|..| ..:|.|
Worm   807 EYTCKADNGIGVPAEGQTFLLVNSAPRVLPVARYAKTAGILGGVAKARCKVYAVP-TVEFVW--- 867

  Fly   907 TENETDENLGSGKKENSVEKSFYILQTDYA---------------ISRTYRCVANNTVG 950
               |.||.|   .|:||.:.|....|.||:               .::..:|:|.|:.|
Worm   868 ---EKDEQL---IKKNSSKYSIVNTQIDYSTYESTLWIKNIVPDDYTKKVKCIARNSFG 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	11/47 (23%)
		Ig	176..248	CDD:299845	23/79 (29%)
		Ig	277..354	CDD:299845	22/83 (27%)
		IG_like	383..463	CDD:214653	23/86 (27%)
		Ig	394..463	CDD:143165	20/75 (27%)
		Ig_3	585..652	CDD:290638	19/79 (24%)
		Ig	685..>719	CDD:299845	6/34 (18%)
		IG_like	788..869	CDD:214653	21/89 (24%)
		Ig	<811..869	CDD:299845	16/66 (24%)
syg-2	NP_001309674.1	IG_like	25..105	CDD:214653	6/24 (25%)
		Ig	33..122	CDD:299845	11/46 (24%)
		Ig	147..228	CDD:299845	26/90 (29%)
		IGc2	248..313	CDD:197706	23/84 (27%)
		Ig	450..537	CDD:299845	24/100 (24%)
		Ig	559..632	CDD:299845	21/89 (24%)
		I-set	657..738	CDD:254352	20/106 (19%)
		Ig	665..738	CDD:299845	18/98 (18%)
		IG_like	748..828	CDD:214653	20/83 (24%)
		IGc2	756..817	CDD:197706	17/64 (27%)
		Ig	845..922	CDD:299845	20/86 (23%)
		FN3	934..1023	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810