DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and egl-15

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001300356.1	Gene:	egl-15 / 181291	WormBaseID:	WBGene00001184	Length:	1153	Species:	Caenorhabditis elegans

Alignment Length:	1313	Identity:	234/1313 - (17%)
Similarity:	410/1313 - (31%)	Gaps:	493/1313 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 VLLNCEYFANPASLTQVEWYRNDILVNVNDTTHYKGGNSEN--VALVIKSTEKEDIGNYSCQLSN 456
            :..:|:..|:..| ..|||||||.|:. ||.........:|  :.|.:|:.:..|.|.:||::.|
Worm    51 IKFDCQTAASKIS-AFVEWYRNDKLLK-NDQIDKDKIRKDNNRMMLHLKNIDVSDQGLWSCRVHN 113

  Fly   457 NIGKGTSDQKINL----DVQYAPTVEILMIPEGPV------KESDESNVTLFCNVLDANPSVLTK 511
            ..|:.:.:..:.:    |....|.:..|.||...|      ||:..|:|    |.......|.:|
Worm   114 AYGQISRNFTVEVIDFCDYFLFPDIHHLNIPMECVCLWKYNKEAKRSDV----NYAAVTGEVCSK 174

  Fly   512 VRWYANSTL---LKELP--DCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAA-----GWG 566
               ||:..:   .|.||  .|                         :...|:.|:..     |..
Worm   175 ---YASRMINRARKPLPMIPC-------------------------FGDHCKEFDTTPVSDFGLP 211

  Fly   567 PRSEDKELLVHYEPGPAALSHFPLVAVKKKSVTFSCSVDDPGFPESNRFRWLRGGRGPLQDIVTK 631
            .:.||..|:..             |.:||..|..... |....|..:|..::.......::...:
Worm   212 GKPEDDPLVKR-------------VVLKKDDVIVPVH-DSEESPSESRTEFINADEKENKEDEEE 262

  Fly   632 DWTV-EPVGLDSRTNYSCYAYNEGGKGVMATVNLEVHAPPFFIKN----LPPYTGILHSSPNATL 691
            |::| :||..|:.               :..:|:....||:|..|    |...|..|.:.....|
Worm   263 DYSVSQPVAPDAG---------------LTELNITAEEPPYFKSNDNIVLFNETHALPAGRTLKL 312

  Fly   692 TCRIECVPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWP-DSKFN 755
            .||.:..|...|.|.|:|..::::.:|             :|.:|       |....|. :.:..
Worm   313 NCRAKGYPEPQIIWYKNGKMLKKSSAR-------------SGGYE-------FKFNRWSLEVEDA 357

  Fly   756 IEADNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTIPGRVICKSRANPEPS 820
            :.||:..:.|.:...:  ||  ::.||                         .||..:|....|.
Worm   358 VVADSGEFHCEALNKV--GS--AKKYF-------------------------HVIIVNRMRRPPI 393

  Fly   821 YKWIFKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKPRCEIERQEIDDQ 885
               |..|        ::.|.::|.||..|:.|    |..|.:...:|.|:.
Worm   394 ---IVPN--------ILANQSVNINDTATFHC----KVVSDLLPHIIWVRI-------------- 429

  Fly   886 DTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKS-------------FYILQTDYAI 937
                     |.|...:|:   ..|..:|.:.:..:.::.:|:             |.:...|..|
Worm   430 ---------NKINGSYSY---YNNSAEEYMFNYTEMDTFDKAHVHHVGDESTLTIFNVSLDDQGI 482

  Fly   938 SRTYRCVANNTVGYG-PFCEIEVAEQLAWWQL---------WEKNTLIILVAAILGLLLTVIVIC 992
               |.|::.|::|.. ....:.|.|.:|...|         |..:..|.  ..||..||....:.
Worm   483 ---YACLSGNSLGMSMANATLTVNEFMAIHLLTGDEPKIDRWTTSDYIF--TTILLFLLLAATLF 542

  Fly   993 CIIICICRR---------------RRRQDKYLTEVPINSIQSALSDQLDMSRAGRNLSTQDKCTA 1042
            .|:..:|::               .|::...:::.|:|.......|:
Worm   543 GILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDE------------------ 589

  Fly  1043 ILPNPSSSRFIGSAPKSPPRWPIRPGVMLHVSSNTKENLTVNRMTVKPNVSGNRGDMSQLSAQLS 1107
              |:|...:.|.:        ||           ||:.                          :
Worm   590 --PSPYQIQIIET--------PI-----------TKKE--------------------------A 607

  Fly  1108 AALNGSRDNSDGTILTEISAVSG---ENEASNLSILEVTNRKKATVPSTIRNVSTAEGEIISSKT 1169
            |.....|.||:.|:|:|....|.   |.|.|.||::
Worm   608 ARKQRKRMNSENTVLSEYEVDSDPVWEVERSKLSLV----------------------------- 643

  Fly  1170 HSAGHIALDHVWSLIFKKSDDR------TRDSQRSH-------VGLLQTFWRGLGAKESTSGFES 1221
            |..|..|...||...:|::::.      .:....:|       |..::|| :.:|..|:..
Worm   644 HMLGEGAFGEVWKATYKETENNEIAVAVKKLKMSAHEKELIDLVSEMETF-KVIGEHENVL---- 703

  Fly  1222 QHRLKGIRCSGS-----------------------VTYKKAKETVHSTSD----AASNGESSLTK 1259
              ||.|. |:|:                       ...:|||::....:|    ..::.:..:..
Worm   704 --RLIGC-CTGAGPLYVVVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIEL 765

  Fly  1260 RPNNCQPSV---SIQLQSNMEEKTSKFVLKDERNNSSTEV----------------ENIPCNMVP 1305
            .||..|..:   :.|:...|....||.::  .|:.::..|                .::.||
Worm   766 IPNLTQRHLVQFAWQVAQGMNFLASKKII--HRDLAARNVLVGDGHVLKISDFGLSRDVHCN--- 825

  Fly  1306 SITRGSSIESPQRPAPSSLPLK---------NFLNVTS--WGCS---------GNS--------- 1341
                    :..::.....||:|         |...|.|  |...         |.:
Worm   826 --------DYYRKRGNGRLPIKWMALEALDSNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPE 882

  Fly  1342 ---------TMVPSHILANEQIHDKSSSLREPLTEPGEYE-------------NLPFHGLQTAPN 1384
                     .|.|.|:...|..|...|..||.|.|...::             |....|.|...:
Worm   883 LYANLKEGYRMEPPHLCPQEVYHLMCSCWREKLEERPSFKTIVDYLDWMLTMTNETIEGSQEFND 947

  Fly  1385 KFSTTPTNFNNNTNAVRVAQRPKE---LIGNINQPSVGLYQDCQATHDPLLYHQKYFCDQDALND 1446
            :|.:..:..:...:.:...|:.::   |...:|.||           :|    |...||     |
Worm   948 QFFSERSTASGPVSPMESFQKKRKHRPLSAPVNLPS-----------EP----QHTICD-----D 992

  Fly  1447 QRSQYTTMHRPPNNVQY---NQSLFK-----PD-SNLQDQHNLSNCISKSYTEYYQQHQRSEKLQ 1502
            ..|.::.  .|||:..:   |.::.|     |: |.|.....|:..|...|.       |.:||.
Worm   993 YESNFSV--EPPNDPNHLYCNDNMLKNHIITPETSQLYIHKVLNEPIGNGYV-------RQDKLA 1048

  Fly  1503 MIFPQGASKELNS 1515
            ......|::.|:|
Worm  1049 RAVSGVANQSLDS 1061

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845
		Ig	277..354	CDD:299845
		IG_like	383..463	CDD:214653	22/70 (31%)
		Ig	394..463	CDD:143165	22/70 (31%)
		Ig_3	585..652	CDD:290638	12/67 (18%)
		Ig	685..>719	CDD:299845	8/33 (24%)
		IG_like	788..869	CDD:214653	15/80 (19%)
		Ig	<811..869	CDD:299845	13/57 (23%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653	22/76 (29%)
		Ig	47..126	CDD:299845	22/76 (29%)
		Ig	302..382	CDD:299845	21/128 (16%)
		IG_like	306..384	CDD:214653	21/126 (17%)
		IG_like	401..502	CDD:214653	23/133 (17%)
		Ig3_FGFR	407..503	CDD:143175	21/128 (16%)
		PKc_like	627..933	CDD:304357	56/355 (16%)
		Pkinase_Tyr	640..928	CDD:285015	52/337 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000