DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment nrm and SIRPA

DIOPT Version :9

Sequence 1:NP_001246890.1 Gene:nrm / 40515 FlyBaseID:FBgn0262509 Length:2192 Species:Drosophila melanogaster
Sequence 2:NP_001317657.1 Gene:SIRPA / 140885 HGNCID:9662 Length:508 Species:Homo sapiens


Alignment Length:471 Identity:97/471 - (20%)
Similarity:159/471 - (33%) Gaps:127/471 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 VLCLALVDS------------STAQVDTTISQQESQSVVLPCPVDAEKCGKLHSLNWFKGDDRIA 84
            :|||.|..|            ...|.|.::.....::..|.|  .|.....:..:.||:|.....
Human    14 LLCLLLAASCAWSGVAGEEELQVIQPDKSVLVAAGETATLRC--TATSLIPVGPIQWFRGAGPGR 76

  Fly    85 AMLLGDS-----NVTSVNKEFDERVTVEQN-PYRLVIKDLKIADEDIYLC---------DTTFFI 134
            .::....     .||:|:.     :|...| .:.:.|.::..||...|.|         |..|  
Human    77 ELIYNQKEGHFPRVTTVSD-----LTKRNNMDFSIRIGNITPADAGTYYCVKFRKGSPDDVEF-- 134

  Fly   135 PEETCDNFNGYRIELRVLVPPTEVVILDAKGDRIKNGSVVGPMQE---RQSLKATCTVRNTRPQP 196
                   .:|...||.|...|:..|             |.||...   :.::..||......|:.
Human   135 -------KSGAGTELSVRAKPSAPV-------------VSGPAARATPQHTVSFTCESHGFSPRD 179

  Fly   197 -EVSWFRGTKRL----TTYSPTHDLVDGLYTSTLELDWTLSREDLAQDIECRVKSAAIQNVTV-- 254
             .:.||:....|    |...|..:.|.....||.::  .|:|||:...:.|.|....:|...:  
Human   180 ITLKWFKNGNELSDFQTNVDPVGESVSYSIHSTAKV--VLTREDVHSQVICEVAHVTLQGDPLRG 242

  Fly   255 -TKFSVDLQVRPTSIDINGVKHHTVQG-SKVVLTCDIHGARP-AVNLTWYNTTTIISSGENEITE 316
             ...|..::|.||.    .|....|:. ::|.:||.:....| .:.|||      :.:|....||
Human   243 TANLSETIRVPPTL----EVTQQPVRAENQVNVTCQVRKFYPQRLQLTW------LENGNVSRTE 297

  Fly   317 VRSKSLEKSDGTFHTQSELIFNATRFENDRVFRCEAE---------------------------- 353
            ..|...|..|||::..|.|:.|.:...:|....|:.|                            
Human   298 TASTVTENKDGTYNWMSWLLVNVSAHRDDVKLTCQVEHDGQPAVSKSHDLKVSAHPKEQGSNTAA 362

  Fly   354 --------NIVLQINREKPISSALTLEVLYPPVVKVSPSAITANTSEIVLLNCEYFANPASLTQV 410
                    ||.:.:.....:..||.:..||  :|::.......:||...|...|  .|...:|||
Human   363 ENTGSNERNIYIVVGVVCTLLVALLMAALY--LVRIRQKKAQGSTSSTRLHEPE--KNAREITQV 423

  Fly   411 EWYRNDILVNVNDTTH 426
            :      .::.||.|:
Human   424 Q------SLDTNDITY 433

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
nrmNP_001246890.1 Ig 44..152 CDD:299845 23/122 (19%)
Ig 176..248 CDD:299845 18/79 (23%)
Ig 277..354 CDD:299845 22/114 (19%)
IG_like 383..463 CDD:214653 11/44 (25%)
Ig 394..463 CDD:143165 9/33 (27%)
Ig_3 585..652 CDD:290638
Ig 685..>719 CDD:299845
IG_like 788..869 CDD:214653
Ig <811..869 CDD:299845
SIRPANP_001317657.1 IgV_SIRP 35..145 CDD:319346 23/125 (18%)
IgC_SIRP_domain_2 147..250 CDD:319314 24/117 (21%)
IgC_SIRP_domain_3 252..355 CDD:319334 26/112 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..364 0/27 (0%)
SH2-binding. /evidence=ECO:0000255 433..436 0/1 (0%)
SH3-binding. /evidence=ECO:0000255 443..448
SH2-binding. /evidence=ECO:0000255 457..460
SH2-binding. /evidence=ECO:0000255 474..477
SH2-binding. /evidence=ECO:0000255 500..503
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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