DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment nrm and si:ch211-180a12.2

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	XP_001920945.3	Gene:	si:ch211-180a12.2 / 100150385	ZFINID:	ZDB-GENE-121214-236	Length:	903	Species:	Danio rerio

Alignment Length:	944	Identity:	185/944 - (19%)
Similarity:	321/944 - (34%)	Gaps:	323/944 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LSLVLVLCLALVDSSTAQVDTTISQQESQ----SVVLPCPVDAEKCGKLHSLNWFKGDDRIAAML 87
            ||.:.:|.|....||   ||.::|...|.    |..||..||    ..|.::.|..|...||:
Zfish     6 LSYLWLLGLIKAGSS---VDVSVSPGSSTVLNCSFALPALVD----NSLLNITWSSGGSIIAS-- 61

  Fly    88 LGDSNVTSVNKEFDERVTVEQNPYRLVIKDLKIADEDIYLCDTTFFIPEETCDNFNGYRIE--LR 150
               .|.|...  |....|...: :.|.:.:.....:.:|.|..::        |...|..|  |.
Zfish    62 ---KNHTQAG--FFLNSTAFPS-FPLTVFNATPHQQGVYECRVSY--------NDTDYATEVTLT 112

  Fly   151 VLVPPTEVVILDAKGDRIKNGSVVGP--MQERQSLKATCTVRNTRPQPEV--SWFRGTKRLTTYS 211
            :|.||  ||            |::.|  :.:|:|: ..|..|:..| |::  :|.||..::  ..
Zfish   113 ILAPP--VV------------SIISPEAVLKRKSV-VECWARSFSP-PQIMFTWTRGGNKI--QE 159

  Fly   212 P----THDLVDGLYTSTLELDW--TLSREDLAQDIECRVKSAAIQNVTVTKFSVDLQVRP-TSID 269
            |    .:...||||.:...|.:  .:|.::::  ..|.|:.:|:....:.:|:..:.|.| .::.
Zfish   160 PQKLQVNRTEDGLYDAVSFLTFIPQISNQNIS--FGCEVQHSALVKPVLEEFTPHITVLPKVTLS 222

  Fly   270 INGVKHHTVQGSKVVLTCDIHGARP-AVNLTWYNTTTIISSGENEITEVRSKSLEKSDGT----- 328
            :.....|:   |.|.|:|||.|..| .:::.|      |.:|: :::|: ..|::..|||
Zfish   223 VVPSSSHS---SSVTLSCDISGFYPNNISVLW------IHNGK-KLSEL-PLSIQNEDGTYRRHQ 276

  Fly   329 FHTQSELIFNATRFENDRVFRCEAENIVLQINREKPIS-----SALTLEVLYPPVVKVSPSAI-- 386
            :||       .||.|..|  ..|.:.:.||.:.::|.:     |.:.|.|..|.:.|.:.:::
Zfish   277 YHT-------LTREERSR--GGEVQCVALQPSGQEPANGTIDLSTVDLRVQNPGLNKSAKASVAM 332

  Fly   387 -------------------------TANTSEIVL-----------LNCEYFANPASLTQVEWYRN 415
                                     :.|.|.|||           :........|...|..|:.|
Zfish   333 MIISLTLVFLLCFGFSWKRRDEKLKSLNISAIVLPPRVVVGKKGRVTISVEGRLAERVQTTWFLN 397

  Fly   416 DILVNVNDTTH------------YKGGNSENVALVIKSTEKEDI------GNYSCQLSNNI-GKG 461
            ||  .:.||:|            |...||....|    :||..:      |.|.......: ...
Zfish   398 DI--PIKDTSHKEKKYGAFRSASYTSRNSSVSVL----SEKNPLLPSSASGYYKLHTQMPLRSSS 456

  Fly   462 TSDQKINLDVQYAPTV-----------------------------EILMIPEGPVKESDESN--- 494
            .|.:::...|.:.|::                             .||..||....:..|.|
Zfish   457 NSSKQLFSSVTFIPSLAVHKGSVFKCQVSYKGKDKIVAERVSEKFTILAPPEVSEIQFSEPNEEG 521

  Fly   495 --VTLFCNVLDANPSVLTKVRWYAN----------STLLKELPDCEETREDLCHIDPSKLLLESI 547
              ||:..:....:|.::| .||:..          ..|....||.|
Zfish   522 GVVTMTAHASHFHPDIIT-FRWFCEGGELSPVSIPQALAAPRPDAE------------------- 566

  Fly   548 GRGFFYNYS-CEGFNAAGWGPRSEDKE------LLVHY----------------EPGPAALSHFP 589
              |||...| |.       .|::|.:.      :.:|:                :|..:.:...|
Zfish   567 --GFFSAMSQCR-------LPKAELERGETRVWVTIHHTALKQPITRQTRGFIKQPSISEILSCP 622

  Fly   590 LVAVKKKSVTFSCSVDDPGF-PESNRFRWL--RGGR------------------GPLQDI----- 628
            :.:|.:..:|.:|.:  .|| |.....:||  :|..                  ||||.:
Zfish   623 VASVLEGRLTLACEI--TGFYPPEISVKWLHSKGNEIEDGDDSEEEIKDGAEVWGPLQTLPRTFR 685

  Fly   629 ---VTKDWTVEPVG--LDSRTNYSCYAYNEGGKGVMATV-----NLEVHAPPFFIKNLPPYTGIL 683
               :.||......|  :..|.::.|         ::..|     |....||     ::||...:.
Zfish   686 AKALLKDVNEMTRGGQIICRVSHCC---------LLKPVDRVWRNTHTVAP-----SIPPSLSVH 736

  Fly   684 HSSPNATLTCRIEC--VPRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVL---- 742
            .||....:...:.|  .|..::.|...|..:.|..|    ||:..:.:....:.:|:.:::
Zfish   737 WSSDGVGIFSIVLCGGRPSAEVLWAAGGSTLSRLQS----KERERENNEGKLELKSVCALVRSTG 797

  Fly   743 ----------HFNMPNWPDSKFNIEADNANYSCV 766
                      |......|...||.:.:..| .||
Zfish   798 RKDSESRRGTHARKIRPPSVDFNTDYEKVN-ECV 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845	25/113 (22%)
		Ig	176..248	CDD:299845	19/81 (23%)
		Ig	277..354	CDD:299845	23/82 (28%)
		IG_like	383..463	CDD:214653	22/136 (16%)
		Ig	394..463	CDD:143165	19/98 (19%)
		Ig_3	585..652	CDD:290638	19/97 (20%)
		Ig	685..>719	CDD:299845	8/35 (23%)
		IG_like	788..869	CDD:214653
		Ig	<811..869	CDD:299845
si:ch211-180a12.2	XP_001920945.3	Ig	19..114	CDD:299845	27/117 (23%)
		IG_like	22..113	CDD:214653	24/110 (22%)
		C1-set	123..205	CDD:284964	20/87 (23%)
		IgC	237..309	CDD:143166	23/88 (26%)
		IgC	515..604	CDD:143166	20/117 (17%)
		IgC	609..720	CDD:143166	21/121 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3515
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900