DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nrm and si:ch73-208g10.1

DIOPT Version :9

Sequence 1:	NP_001246890.1	Gene:	nrm / 40515	FlyBaseID:	FBgn0262509	Length:	2192	Species:	Drosophila melanogaster
Sequence 2:	NP_001091731.1	Gene:	si:ch73-208g10.1 / 100002730	ZFINID:	ZDB-GENE-040108-6	Length:	899	Species:	Danio rerio

Alignment Length:	994	Identity:	193/994 - (19%)
Similarity:	335/994 - (33%)	Gaps:	328/994 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 TSTLELDWTLSRE--------------DLAQDIECRV----KSAAIQNVTVTKFSVDLQVRPTSI 268
            |..|.|.|..::|              :...:..|.:    .....||::||.:..     |.|:
Zfish    49 TDHLGLSWEPNKEAAEKTGEISKTLVGEWESEFSCYIYFNETQPCSQNLSVTIYKT-----PDSV 108

  Fly   269 DINGVKH--HTVQGSKVVLTCDIHGARPAVNLT--WYNTTTIISSGENEITEVRSKSLEKSDGTF 329
            .|:.:.|  ..::|.:..|.||::...||.:||  ||...|:::  :...|:....|:..:
Zfish   109 SISALNHTGPMIEGIQYELQCDVYNVAPAQSLTVNWYKGKTLVN--QTSFTDTSKSSVNMT---- 167

  Fly   330 HTQSELIFNATRFENDRVFRCEAENIVLQINREKPISSALTLEVLYPPVVKVSPSAITA------ 388
               |.|:....|.:|:..:||||   .|.:..|.|..         ||.|...|.:||.
Zfish   168 ---SYLLIQPDRTDNEAQYRCEA---ALNLGEEGPQP---------PPTVTSEPLSITVKYDCPI 217

  Fly   389 --NTSEIVL-------LNCE------------------------------------------YFA 402
              |.||:|:       :||.                                          ||.
Zfish   218 SFNFSEVVVEYGASFSVNCSAETTKYLGLSWELNEETVEITSEISKTVDQMTEWEGKFSCYIYFN 282

  Fly   403 N----------------------------------------------PASLTQVEWYRNDILVN- 420
            |                                              ||....|:||:.|.|||
Zfish   283 NTHPCSRTYSVTIYKTPDSVSISTVNHTGPMTVGKQYELQCDVHNVAPAQSLTVKWYKGDTLVNQ 347

  Fly   421 --VNDTTHYKGGNSENVALVIKSTEKEDIGNYSCQLSNNIG-KGTSDQKINLDVQYAPTVEILMI 482
              ..||:  |...|:...|:|.....:|...|.|:...|:| :|......|.....:.||:...|
Zfish   348 TSFTDTS--KSPVSKTSKLLIHPNRNDDRAQYRCEAELNLGEEGPQPPPKNKSKPLSITVQSHHI 410

  Fly   483 PEG--PVKESDE-------SNVTLFCNVLDANPSV----------LTK---VRWYANSTLLKELP 525
            .:|  |::....       |:|:..|.....:..:          |:|   :.|     .:.:|.
Zfish   411 LDGGCPIELKPRRAVVKYGSSVSADCKSFVPHDGIGWESTVGGVPLSKASLITW-----RVSQLT 470

  Fly   526 DCEETREDLCHIDPSKLLLESIGRGFFYNYSCEGFNAAGWGPRSEDKELLVHYEPGPAALSHFPL 590
            |. |.:...|:|:              |...||           ....:.::..|...::|....
Zfish   471 DW-EIQPPFCYIN--------------YKQQCE-----------VALPVTIYKTPDSVSISAVNQ 509

  Fly   591 VAVKKKSVTFSCSVDDPGFPESNRFRWLRG------------GRGPLQDIVTKDWTVEPVGLDSR 643
            ...:.......|.|.:....:|....|.:|            .:.|:.  :|....:.||..|:.
Zfish   510 AMTEGNQYELQCDVHNVAPAQSLTVNWYKGETLVNQTNFTDTTKSPVN--ITSYLLIHPVRADNG 572

  Fly   644 TNYSCYA---YNEGG-----KGVMATVNLEVHAPPFFIKNLPPYT----GILHSSPNATLTCRIE 696
            ..:.|..   ..|.|     |.....:::.||..| .||:..|::    ..|.|.|.     .:.
Zfish   573 AQFRCETELNLGEEGPQPPPKNTSKPLSIPVHYAP-EIKSCQPWSPKKGSSLDSYPK-----HLH 631

  Fly   697 CV---PRCDISWQKDGVPIERNDSRYFIKEKYMDASPATGDFESMLSVLHFNMPNWPDSKFNIEA 758
            .|   |...|||:.:..|:..             ::|.|                        |.
Zfish   632 SVVGNPHPSISWKHNSSPVNA-------------SAPLT------------------------ET 659

  Fly   759 DNANYSCVSTGNIVGGSIRSRTYFGIEYAPENTTVSENIVYVQEDTI--PGRVICKSRANPEPSY 821
            |:..|...::.:.  |.........:||:||  .:.|....|:|.|:  |    |.....|:|..
Zfish   660 DSGQYEITASNHY--GESNCTISITVEYSPE--LICEESYEVKEKTVFSP----CDVEGEPKPEL 716

  Fly   822 KWIFKNETIANGNALIINTAMNRNDDGTYTCLAYNKHGSSIAKTVIKVQFKPRCEIERQEI---- 882
            . ::|     .|..:.:......||.|.|...|.|||||......|.||:.||....:|:.
Zfish   717 S-LYK-----EGKRIQLFNGFKWNDSGLYQLTARNKHGSVNKSLTINVQYAPRLFASQQDFVVAK 775

  Fly   883 DDQDTLICTAYGNPIEADFSWSIKTENETDENLGSGKKENSVEKSFYILQTDYAISRTYRCVANN 947
            |.:..|.|.:.||| |.:..||.     .::|:.:|::    ..:|.|.:.....:..|.|:|.|
Zfish   776 DYRIILQCNSSGNP-EPEMWWSF-----NNKNISTGRR----YITFNIEKATSTSAGNYTCIARN 830

  Fly   948 TVGYGPFCEIEVAEQLAWWQLWEKNTLIILVAAILGLLLTVIVICCIIICICRRRRRQDKYLTEV 1012
            .:|.        .|::...::.:.:...:|:|.::.||  |:::.|::..:.||:|...:|
Zfish   831 EIGR--------QEKVFTVKIKDNSRSYVLIAVVISLL--VLLLICLLFFLWRRQRASGRY---- 881

  Fly  1013 PINSIQSALSDQLDMSRAG 1031
            .:.:::|  ::.:.:|..|
Zfish   882 DVTTLKS--NEMVPLSNGG 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nrm	NP_001246890.1	Ig	44..152	CDD:299845
		Ig	176..248	CDD:299845	6/43 (14%)
		Ig	277..354	CDD:299845	21/78 (27%)
		IG_like	383..463	CDD:214653	33/186 (18%)
		Ig	394..463	CDD:143165	27/167 (16%)
		Ig_3	585..652	CDD:290638	12/81 (15%)
		Ig	685..>719	CDD:299845	8/36 (22%)
		IG_like	788..869	CDD:214653	23/82 (28%)
		Ig	<811..869	CDD:299845	16/57 (28%)
si:ch73-208g10.1	NP_001091731.1	Ig	105..207	CDD:299845	31/122 (25%)
		Ig	299..401	CDD:299845	22/103 (21%)
		Ig2_ICAM-1_like	499..599	CDD:143232	16/101 (16%)
		Ig	635..684	CDD:299845	11/87 (13%)
		IG_like	693..758	CDD:214653	20/74 (27%)
		IGc2	701..748	CDD:197706	14/56 (25%)
		I-set	769..843	CDD:254352	20/91 (22%)
		Ig	776..843	CDD:299845	19/84 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910