DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BoYb and TDRD12

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	XP_011525773.1	Gene:	TDRD12 / 91646	HGNCID:	25044	Length:	1335	Species:	Homo sapiens

Alignment Length:	758	Identity:	162/758 - (21%)
Similarity:	302/758 - (39%)	Gaps:	103/758 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPI 145
            :||:||.:|.|..   ::|.|........|:.||...:.      ||.|..     |.|.|.||:
Human   443 ESYSWPPIARGCD---VVVISHCESNPLLYLLPVLTVLQ------TGACYK-----SLPSRNGPL 493

  Fly   146 ALILVPDLRRVHQVSAMCLALLRKAHKNDS------VTLALNVSSTKSSQFFLKLLNGVGCLVAT 204
            |:|:.|..::...:    ..||.:...:..      :|:.|:....|::    ||..|...:|.|
Human   494 AVIVCPGWKKAQFI----FELLGEYSMSSRPLHPVLLTIGLHKEEAKNT----KLPRGCDVIVTT 550

  Fly   205 PAQLVWFWQEAPGLMRFPCLQF-----LVYDDVDLMSREQLQDVQQVLQ------EILPLSHSP- 257
            |..|:       .|:....|.|     |:.|:|:::..|..:.:..:|.      |:.....:|
Human   551 PYSLL-------RLLACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPH 608

  Fly   258 QVVMVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSP 322
            |:|.|...:...:...::...:.|.:|...:.||||||..:..:.:.....|.::::|.|.....
Human   609 QIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEKTSSLLQALDFIPS 673

  Fly   323 EEFRTVIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQVHSWQAR-SNG--VILLCTDNC 384
            :..:|:||.....:.:.:...:|.....||..::.....::..:..|:.: |:|  :||..||:|
Human   674 QAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDC 738

  Fly   385 -PELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKPLYSLVLLDDNNHRQLP 448
             |.|.|.||..:||.|...|...|..|...:||:........|....|...|::||.:.:.....
Human   739 VPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAV 803

  Fly   449 RLVDFLQ-LHQKVDHRLVEVAKRIRQELGKARNDQ---HQLCDQILVLGKCY------DPVCESR 503
            .::.:|: ...||...|.|....:.:    |:.|:   ..||..:...|.|.      ..:|..|
Human   804 GVLRYLERADAKVPAELYEFTAGVLE----AKEDKKAGRPLCPYLKAFGFCNHFIFRDKRICPDR 864

  Fly   504 HRLSHIDRRP-----DYLPASGDVKVQLVKVYSPTHFCVRLLE-HLPPKGTW--RMMEYSAVQEF 560
            ||::.....|     ..||:.|.:|:....:.:.|::..|::: |:....|.  .|.||     |
Human   865 HRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEY-----F 924

  Fly   561 R-MQLTQIKEPRRYWPPVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQALDVDTRI 624
            : ...|.:::..::.........::|      ||:||:|.. |.......|:.|:.  :| :.|.
Human   925 KDSNKTTVEKVEKFGLYGLAEKTLFH------RVQVLEVNQ-KEDAWALDDILVEF--ID-EGRT 979

  Fly   625 FSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPKDHFLQAKIL 689
            ......:|...||......|.|.:..:....|...|..|..:..|.::..:  :.|.|  .||::
Human   980 GLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKI--VGKLH--DAKVI 1040

  Fly   690 FVAAGTLFVQDLVAIMYADQFKAHVRHLSLARRLVEATL-VKRSENAAEM--IREFFAEVIIEDD 751
            .....|:::..:|.|......|..|...::...::...: :...|:..::  :||.......|:.
Human  1041 LALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPACEES 1105

  Fly   752 IDEN----VQDSKEKANSKPHEKMKGKMT---DQPAKLQSQPP 787
            :.:.    ...|..:....|.|:..|:.|   :..|.|||..|
Human  1106 LSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACLQSPQP 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	46/199 (23%)
TDRD12	XP_011525773.1	TUDOR	10..128	CDD:278965
		TUDOR	60..109	CDD:119391
		P-loop_NTPase	419..635	CDD:304359	48/220 (22%)
		SrmB	422..881	CDD:223587	106/470 (23%)
		P-loop_NTPase	659..762	CDD:304359	26/102 (25%)
		TUDOR	<913..1004	CDD:278965	22/105 (21%)
		alpha-crystallin-Hsps_p23-like	1193..1297	CDD:294116
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910