DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BoYb and tdrd12

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	XP_012816810.2	Gene:	tdrd12 / 780068	XenbaseID:	XB-GENE-953299	Length:	1201	Species:	Xenopus tropicalis

Alignment Length:	906	Identity:	189/906 - (20%)
Similarity:	334/906 - (36%)	Gaps:	198/906 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPI 145
            :||:||.:|.|..   .||.||...:...||||:...:..|...:|          ..|.|.||:
Frog   357 ESYSWPSVAQGFN---TIVISPDGMKPMNYIPPLLTFLHLASAVYT----------LLPSRNGPL 408

  Fly   146 ALILVPDLRRVHQVSAMCLALLRKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVATPAQLVW 210
            |.||....::.|.|..:.|...:.....:.:.:.:.:...:...  |.:..|...:|.||
Frog   409 AAILCSGWKKAHFVHELLLKYSKHTRPLNPMLILVGLKEEECEN--LNIRKGCEVIVTTP----- 466

  Fly   211 FWQEAPGLMRF-PC-------LQFLVYDDVDLMSREQLQDVQQVLQEILPL----------SHSP 257
                 |.|:|: .|       |..||.|:||::.   |:...||: |||.|          ..:|
Frog   467 -----PSLLRYLKCKGLLLLRLCHLVLDEVDILF---LKSGSQVI-EILELFKKSVAAESRECAP 522

  Fly   258 QVVMVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSP 322
            |.::.:.::.|..|:.|.....:|.::...:.:||:||..:..|.:.....|.:.:::.|.....
Frog   523 QQIVATGTFWHKEMNSLLQYTTEPQVIITRMEQAAVYGNVQQVIQLCLDCEKISVLLRNLDFTPD 587

  Fly   323 EEFRTVIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEV-RQQVHS-------WQ---ARSNGV 376
            ...:.:||...|.:.:.:..|  ||::|..      .|.| |:||.|       |:   :|...:
Frog   588 HAQKVLIFVESDEEAELVHKA--VQNHSIF------SLVVNRKQVQSFSSVLQQWKNMLSRGTHI 644

  Fly   377 ILLCTDN-CPELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKK-PLYSLVLL 439
            :|:.|:. .|.|::.||..|||.|...:.:.|.||...:.|.:.:..:...|:... |:...|||
Frog   645 VLVVTNEYLPLLEVTDATCIIHFSFPENENVFGLRLYSLLDYIHSKTERVISLEDSFPVARSVLL 709

  Fly   440 DDNNHRQLPRLVDFLQLHQKVDHRLVEVAKRIRQELGKA---RNDQHQLCDQILVLGKCYDPV-- 499
            ....|  :....|.|:..|..:..:......:.|.:.:|   |.....:|..|...|.|...:
Frog   710 MTEKH--IHHSTDILRYLQHTEATIPPELSDLTQGILQANENRKFDKDICQHIKTFGVCRLNLFT 772

  Fly   500 CESRHR-LSHIDRRPDYLPASGDVKVQLVKVYSPTHFCVR----------LLEHLP-----PKGT 548
            |..||. |...|.:......:..:.|..|.|..|.||..|          |||.|.     |...
Frog   773 CPDRHNLLPSTDHQYSMTTTNQYISVVPVHVLDPVHFFGRIVTKEDVYTHLLEDLNKFYQIPGNQ 837

  Fly   549 WRMMEYSAVQEFRMQLTQIKEPRRYWPPVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTV 613
            ..:.|.:..|.:.:|              .|::  ||.         :||.:.|..|.|   |..
Frog   838 ILVQEVNVSQLYAVQ--------------EGSV--YHR---------VKVFSAKKENGV---LNF 874

  Fly   614 KLQALDVDTRIFSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQL 678
            .||.:| |.|.......:|.:.|...::..|.:.:..:....|...|..|.....|.::..:
Frog   875 SLQFID-DGRTDKVRDAQLLQLPSQFEKIPPQSAEFIVCRVQPIDNEAEWDPIVTRTISKAI--- 935

  Fly   679 PKDHFLQAKILFVAAGTLFVQDLVAIMYADQFKAHVRHLSLARRLVEATL-VKRSENAAEMIREF 742
             |.....||::.....|.::..:|.......|.|.:..|::...::...: |...::.:.:
Frog   936 -KGKLHTAKVVLHIGNTYWLDPMVQRSKLSGFAACINELNVRHEILSTGMGVDNPQHISHL---- 995

  Fly   743 FAEVIIEDDIDENVQDSKEKANSKPHEKMKGKMTDQPAKLQSQPPLSGRCLRL-----ANMAHES 802
             .|::.:..:....|||.:|.:.              |.|.|...::..|:..     ||....:
Frog   996 -EELLKKTGVATVQQDSTDKVSD--------------ADLSSNNMIANCCVSSLSSLDANCGARN 1045

  Fly   803 VK-ENQLHQELQERRYETPEIP--------------HQSNE----------------------SD 830
            |. :|:|.:...|.:...||:.              |...:                      :|
Frog  1046 VDLQNKLERNPLESKSLQPEVKWFQKDKAVILTIKLHDVTDHACMFYASRVVFSCYAGGKHYVAD 1110

  Fly   831 IPQSNEDRFSQLYECIMNCASL--QLEDESKP------AKHPDHVLSESVEFHKIMTNEDA 883
            :....|....:...||.|...:  .|:.:::|      .|||    :.|::|.|...:||:
Frog  1111 LELCEEILNEECECCIKNGEPVITLLKAQNRPWKSLLKQKHP----NVSLDFDKWEDSEDS 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	50/199 (25%)
tdrd12	XP_012816810.2	Tudor_SF	4..167	CDD:413384
		SrmB	336..754	CDD:223587	102/435 (23%)
		Tudor_TDRD12_rpt2	805..923	CDD:410506	31/146 (21%)
		alpha-crystallin-Hsps_p23-like	1064..1166	CDD:412199	16/105 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I4948
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050