Protein Alignment BoYb and Tdrd12

DIOPT Version :10

• Sequence 1: NP_649430.1
• Gene: BoYb / 40512
• FlyBaseID: FBgn0037205
• Length: 1059
• Species: Drosophila melanogaster
• Sequence 2: NP_001355316.1
• Gene: Tdrd12 / 71981
• MGIID: 1919231
• Length: 1277
• Species: Mus musculus
• Alignment Length: 925
• Identity: 197/925 - (21%)
• Similarity: 349/925 - (37%)
• Gaps: 228/925 - (24%)

  Fly    82 SYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPIA 146
            ||:||.:|.|..   |:|.|........|:||:...:.      .|.|..     |.|.|.||:|
Mouse   413 SYSWPPIARGCD---MVVISHCGNDPLLYLPPLLTILQ------MGGCYK-----SLPSRNGPLA 463

  Fly   147 LILVPDLRRVHQVSAMCLALL-------RKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVAT 204
            :|:.|..::...:    ..||       |..|. ..:|:.|:....|:    :||..|...:|.|
Mouse   464 VIVCPGWKKAQFI----FELLGDYSMSSRPLHP-VLLTIGLHKDEAKN----MKLPRGCDVIVTT 519

  Fly   205 PAQLVWFWQEAPGLMRFPCLQF-----LVYDDVDLMSREQLQDVQQVLQ------EILPLSHSP- 257
            |..|:       .|:.:..|.|     ||.|:|.::..|..:.:..:|.      |:.....:|
Mouse   520 PHSLL-------RLLTYRSLLFLRLCHLVLDEVHMLFFEANEQMFAILDNFKKNVEVEERESAPH 577

  Fly   258 QVVMVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSP 322
            |:|.|...:...:...:|.....|.:|...:.||||||..:..:.:.....|.:.::|:|.....
Mouse   578 QIVAVGVHWNKHIDHLVREFMKDPCVVITALEEAALYGSVQQVVHLCLECEKTSTLLQVLDFVPS 642

  Fly   323 EEFRTVIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQVHSWQAR---SNGVILLCTDNC 384
            :..:|:||.....:.:.:...:|.....||..::.....::..:..|:.:   .:.::|..||:|
Mouse   643 QAQKTLIFTCSVAETETVCKVVESNSIFCLKMHKEMAFNLKSILEQWKKKLSPGSHIVLTLTDDC 707

  Fly   385 -PELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVK--PTASIVKKPLYSLVLLDDNNHRQ 446
             |.|.|.||..::|.|...|......|...:||:..::.:  ..|....|...|::||.:.|...
Mouse   708 IPLLAITDATCVVHFSFPSSPKVLGGRLYCMSDHFQSLTEQGSPAEQGDKKTKSVLLLTERNASH 772

  Fly   447 LPRLVDFLQ-LHQKVDHRLVEVAKRI--RQELGKARNDQHQLCDQILVLGKCYDP-VCESRHRLS 507
            ...::.:|: ...|:...|.|....:  .:|..|||   ..||..:...|.|.|. :|..||
Mouse   773 AVGILRYLERADAKIPSELYEFTAGVLEAKEDKKAR---RPLCPYLKAFGFCKDKRICPDRH--- 831

  Fly   508 HIDRRPDY--------LPASGDVKVQLVKVYSPTHFCVRLLE-HLPPKGTW--RMMEY------- 554
            ||:...|.        ||..|.::|....:.:.|::..|::: |:....|.  .|.||
Mouse   832 HINPEMDIPRKLSNKTLPVFGHIRVIPFYISNATNYFGRIIDKHVDLYETLNAEMNEYFKESSNK 896

  Fly   555 -SAVQEFRMQLTQIKEPRRYWPPVAGAICMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQAL 618
             ||.:...:.|..::|               .|.|  :||:||:|:..::|..:.| :.|||
Mouse   897 TSAEKVENLGLYGLEE---------------KTLF--QRVQVLEVSQKEDTWGLGS-ILVKL--- 940

  Fly   619 DVD---TRIFSTNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPK 680
             :|   |::.:.:  :|...||......|.|.:..:....|...|..|..:..|.::..:  :.|
Mouse   941 -IDEGRTKLITRD--QLLLLPEKFHTLPPQAVEFIVCRVKPADSEIEWNPKVTRYIHHKI--VGK 1000

  Fly   681 DHFLQAKILFVAAGTLFVQDLVAIMYADQFKAHVRHLSLARRLVEATLVKRSENAAEMIREFFAE 745
            .|  .||::.....||::..:|          ||..||..:..:
Mouse  1001 MH--DAKVVLALGNTLWIDPMV----------HVTKLSNLKTSI--------------------- 1032

  Fly   746 VIIEDDIDENVQDSKEKANSKPHEKMKGKMTDQPAKLQSQPPLSGRCLRLANMAH-ESVKENQLH 809
                  ||.||:                      |::.|..      :.:.|..| |.:|  :|:
Mouse  1033 ------IDYNVR----------------------AEILSMG------MGIDNSEHLEQLK--KLY 1061

  Fly   810 QELQERRYETPEIPHQSNESDIPQSNEDRFSQLYECIM-----------NCASLQLEDESKPAKH 863
            :|.:...:|  ::|.|::   ||.:.||..     |:.           ...|.:..|..||.
Mouse  1062 KEAKLPAFE--DLPCQTS---IPTTVEDTV-----CLQGTQQGDGGTERGAGSQEDSDNQKPG-- 1114

  Fly   864 PDHVLSESVEFHKIMTNEDATPDHTQEKTALLLLPNNVARPSVTYYQ--TMTTLEFQVFLPEDDH 926
               ||||.:....|   ..|...|.:.           ..|.:.::|  .:..|:.::   .:..
Mouse  1115 ---VLSEDIGSETI---SSAPQPHGRS-----------FHPQIKWFQKDDVVILKIKI---RNVK 1159

  Fly   927 DYKALLLGAQLFFRA 941
            |||......::.|.|
Mouse  1160 DYKCKFFTDRVIFSA 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	DEAD-like_helicase_N	104..>235	CDD:475120	34/142 (24%)
		Tudor_SF	531..663	CDD:470623	32/145 (22%)
		PLN00203	<659..>749	CDD:215101	14/89 (16%)
Tdrd12	NP_001355316.1	Tudor_TDRD12_rpt1	4..165	CDD:410505
		DEAD-like_helicase_N	396..601	CDD:475120	51/217 (24%)
		SrmB	<507..810	CDD:440279	69/312 (22%)
		Tudor_TDRD12_rpt2	863..985	CDD:410506	32/145 (22%)
		alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.	1138..1242	CDD:469641	8/40 (20%)