DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BoYb and Ddx46

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_001268984.1	Gene:	Ddx46 / 212880	MGIID:	1920895	Length:	1032	Species:	Mus musculus

Alignment Length:	380	Identity:	75/380 - (19%)
Similarity:	155/380 - (40%)	Gaps:	68/380 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RPVRRFAEVSLLPDILETMRNLGLNRLLRLQSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVC 115
            :|::.:.:..:...||.:::..|..:...:|:...|.:.  ||...:.:....||:|.|::.|
Mouse   369 KPIKSWVQCGISMKILNSLKKHGYEKPTPIQTQAIPAIM--SGRDLIGIAKTGSGKTIAFLLP-- 429

  Fly   116 HAVSRALMDFTGQCEDVEHDISQPDRYGPIALILVPDLRRVHQVSAMCLALLRKAHKNDSVTLAL 180
              :.|.:||        :..:.:.:  ||||:|:.|......|::..|        |..|.||.|
Mouse   430 --MFRHIMD--------QRSLEEGE--GPIAVIMTPTRELALQITKEC--------KKFSKTLGL 474

  Fly   181 NV----SSTKSSQFFLKLLNGVGCLVATPAQLVWFWQEAPG----LMRFPCLQFLVYDDVDLMSR 237
            .|    ..|..|:...:|..|...:|.||.:::.......|    |.|   :.::|.|:.|.|..
Mouse   475 RVVCVYGGTGISEQIAELKRGAEIIVCTPGRMIDMLAANSGRVTNLRR---VTYVVLDEADRMFD 536

  Fly   238 EQLQ-DVQQVLQEILPLSHSPQVVMVSKSYCHTLMSKLRAVNDKP--------ALVFGDILEAAL 293
            ...: .|.:::..:.|   ..|.||.|.::...:.:..|.:..||        ::|..|:.:
Mouse   537 MGFEPQVMRIVDNVRP---DRQTVMFSATFPRAMEALARRILSKPIEVQVGGRSVVCSDVEQ--- 595

  Fly   294 YGGTRIRISIMRSEAKANAVVQMLQQCSPEEFRTVIFCSD-----DGDMQCLVAALEVQHYSCLP 353
                  ::.::..|.|...::::|...  :|..:||...|     ||.::.|:.|    .|.|:.
Mouse   596 ------QVIVIEEEKKFLKLLELLGHY--QESGSVIIFVDKQEHADGLLKDLMRA----SYPCMS 648

  Fly   354 YYQTADLEVRQQVHSWQARSNGVILLCTDNCPE-LDIRDAHTIIHHSMSHSWSKF 407
            .:...|...|..:.:........:|:.|..... ||::....::::|..:.:..:
Mouse   649 LHGGIDQYDRDSIINDFKNGTCKLLVATSVAARGLDVKHLILVVNYSCPNHYEDY 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	45/190 (24%)
Ddx46	NP_001268984.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..227
		SrmB	344..826	CDD:223587	75/380 (20%)
		Q motif	372..400		3/27 (11%)
		DEADc	378..581	CDD:238167	52/232 (22%)
		DEAD box	529..532		1/2 (50%)
		Helicase_C	618..714	CDD:278689	17/90 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0334
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810