DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BoYb and DDX5

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_001307524.1	Gene:	DDX5 / 1655	HGNCID:	2746	Length:	614	Species:	Homo sapiens

Alignment Length:	475	Identity:	94/475 - (19%)
Similarity:	174/475 - (36%)	Gaps:	106/475 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 EYAVAHANCQLRPVRRFAEVSLLPDILETMRNLGLNRLLRLQSYTWPHLAGGSGHGAMIVGSPAS 104
            |..|...||. :||..|.|.:...::::.:..........:|:..||  ...||...:.|....|
Human    81 EITVRGHNCP-KPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWP--VALSGLDMVGVAQTGS 142

  Fly   105 GRTFAY-IPPVCHAVSRALMDFTGQCEDVEHD--ISQPDRYGPIALILVPD---LRRVHQVSA-M 162
            |:|.:| :|.:.|               :.|.  :.:.|  |||.|:|.|.   .::|.||:| .
Human   143 GKTLSYLLPAIVH---------------INHQPFLERGD--GPICLVLAPTRELAQQVQQVAAEY 190

  Fly   163 CLALLRKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVATPAQLVWFWQEAPGLMRFPCLQFL 227
            |.|...|       :..:...:.|..| ...|..||...:|||.:|:.|.:  .|........:|
Human   191 CRACRLK-------STCIYGGAPKGPQ-IRDLERGVEICIATPGRLIDFLE--CGKTNLRRTTYL 245

  Fly   228 VYDDVDLMSREQLQDVQQVLQEILPLSHSPQVVMVSKSYCHTLMSKLRAVNDKPALVFG------ 286
            |.|:.|.|               |.:...||:        ..::.::|.  |:..|::.
Human   246 VLDEADRM---------------LDMGFEPQI--------RKIVDQIRP--DRQTLMWSATWPKE 285

  Fly   287 --DILEAALYGGTRIRISIMRSEAKANAVVQMLQQC-----------------SPEEFRTVIFCS 332
              .:.|..|.....|.|..:...|..| ::|::..|                 |.:|.:|::|..
Human   286 VRQLAEDFLKDYIHINIGALELSANHN-ILQIVDVCHDVEKDEKLIRLMEEIMSEKENKTIVFVE 349

  Fly   333 DDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQVHSWQARSNGVILLCTDNCPE-LDIRDAHTII 396
            .......|...:....:..:..:.....:.|..|.:........||:.||.... ||:.|...:|
Human   350 TKRRCDELTRKMRRDGWPAMGIHGDKSQQERDWVLNEFKHGKAPILIATDVASRGLDVEDVKFVI 414

  Fly   397 HHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKPLYSLVLLDDNNHRQLPRLVDFL-QLHQKV 460
            ::...:|           |::..:.:..||...|... :......||.:|:..|:..| :.:|.:
Human   415 NYDYPNS-----------SEDYIHRIGRTARSTKTGT-AYTFFTPNNIKQVSDLISVLREANQAI 467

  Fly   461 DHRLVEVAKRIRQELGKARN 480
            :.:|:::.    ::.|..|:
Human   468 NPKLLQLV----EDRGSGRS 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	46/188 (24%)
DDX5	NP_001307524.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..39
		PTZ00110	6..507	CDD:240273	94/475 (20%)
		Q motif	94..122		2/27 (7%)
		DEAD box	248..251		1/2 (50%)
		Transactivation domain	477..614		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..504		2/7 (29%)
		P68HR	498..532	CDD:400414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910