DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment BoYb and DDX42

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	NP_031398.2	Gene:	DDX42 / 11325	HGNCID:	18676	Length:	938	Species:	Homo sapiens

Alignment Length:	447	Identity:	99/447 - (22%)
Similarity:	185/447 - (41%)	Gaps:	65/447 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 RPVRRFAEVSLLPDILETMRNLGLNRLLRLQSYTWPHLAGGSGHGAMIVGSPASGRTFAYI-PPV 114
            ||...||.......::..:|.....:...:|....|  ...||...:.:....||:|.|:| |.:
Human   250 RPGSSFAHFGFDEQLMHQIRKSEYTQPTPIQCQGVP--VALSGRDMIGIAKTGSGKTAAFIWPML 312

  Fly   115 CHAVSRALMDFTGQCEDVEHDISQPDRYGPIALILVPDLRRVHQVSAMCLALLRKAHKNDSVTLA 179
            .|     :||        :.::...|  ||||:|:.|......|:.|.| ....||:...||.:.
Human   313 IH-----IMD--------QKELEPGD--GPIAVIVCPTRELCQQIHAEC-KRFGKAYNLRSVAVY 361

  Fly   180 LNVSSTKSSQFFLKLLNGVGCLVATPAQLV-WFWQEAPGLMRFPCLQFLVYDDVDLMSREQLQ-D 242
            ...|..:.::   .|..|...:|.||.:|: ...::|..|.|   :.:||:|:.|.|.....: .
Human   362 GGGSMWEQAK---ALQEGAEIVVCTPGRLIDHVKKKATNLQR---VSYLVFDEADRMFDMGFEYQ 420

  Fly   243 VQQVLQEILPLSHSPQVVMVSKSYCHTLMSKLRAVNDKP-ALVFGDILEAALYGGTRIRISIMRS 306
            |:.:...:.|   ..|.::.|.::...:....|.:...| .:|.|||.||. ...|:| :.|:.|
Human   421 VRSIASHVRP---DRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEAN-EDVTQI-VEILHS 480

  Fly   307 -EAKANAVVQMLQQCSPEEFRT----VIFCSDDGDMQCLVAALEVQHYSCLPYYQTADLEVRQQV 366
             .:|.|.:.:.|     .||.:    ::|.:...:.:.|...|:.:.::....:...|...|.:|
Human   481 GPSKWNWLTRRL-----VEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKV 540

  Fly   367 HSWQARSNGVILLCTDNCPE-LDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVK 430
            .|...:.:..:|:.||.... |||....|:|::.::..           .|...:.:..|....:
Human   541 ISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARD-----------IDTHTHRIGRTGRAGE 594

  Fly   431 KPL-YSLVLLDDNNHR-QLPRLVDFLQLHQKVDHRLVEVA------KRIRQELGKAR 479
            |.: |:|:...|:|.. .|.|.::  ..:|.|...|:::|      ::.|.:.||.:
Human   595 KGVAYTLLTPKDSNFAGDLVRNLE--GANQHVSKELLDLAMQNAWFRKSRFKGGKGK 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	45/184 (24%)
DDX42	NP_031398.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..203
		Q motif	253..281		3/27 (11%)
		PRK10590	254..688	CDD:236722	97/443 (22%)
		DEADc	255..459	CDD:238167	51/230 (22%)
		DEAD box	407..410		1/2 (50%)
		HELICc	470..601	CDD:238034	28/147 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	737..938
		Necessary for interaction with TP53BP2. /evidence=ECO:0000269\|PubMed:19377511	738..833
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910