DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BoYb and tdrd12

DIOPT Version :9

Sequence 1:	NP_649430.1	Gene:	BoYb / 40512	FlyBaseID:	FBgn0037205	Length:	1059	Species:	Drosophila melanogaster
Sequence 2:	XP_021326385.1	Gene:	tdrd12 / 100334979	ZFINID:	ZDB-GENE-121214-348	Length:	1150	Species:	Danio rerio

Alignment Length:	743	Identity:	168/743 - (22%)
Similarity:	291/743 - (39%)	Gaps:	127/743 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 QSYTWPHLAGGSGHGAMIVGSPASGRTFAYIPPVCHAVSRALMDFTGQCEDVEHDISQPDRYGPI 145
            :||.||.:|.|..   .::.|.:.....:||||:...:           :.|....|...|.||:
Zfish   460 ESYCWPAVARGFD---TVLVSHSGDNPLSYIPPLLMIL-----------QTVSVVSSLAARTGPV 510

  Fly   146 ALILVPDLRRVHQVSAMCLALL---RKAHKNDSVTLALNVSSTKSSQFFLKLLNGVGCLVATPAQ 207
            |:||.|...:|..|    |.||   :..|.....::.|.|...:..:|  |:......||.||..
Zfish   511 AVILCPGWEKVQTV----LELLEDSKATHGLHPTSVLLGVDQDEPKKF--KIQKNCQLLVTTPFS 569

  Fly   208 LVWFWQEAPGLMRFPCLQF-----LVYDDVDLMSREQLQDVQQVLQEILPL-------SHSPQVV 260
            |:       .|:...|..|     ||.|:.||:..:....:..:|:....|       :...|::
Zfish   570 LL-------RLLEAQCFLFLRLCHLVLDEADLLYSQAPDQISIILKHFQQLVCAEERVACPRQII 627

  Fly   261 MVSKSYCHTLMSKLRAVNDKPALVFGDILEAALYGGTRIRISIMRSEAKANAVVQMLQQCSPEEF 325
            .|...:...:...:|.....|.::...:.||||||....|:.:.....|.:.::..|....|:..
Zfish   628 AVGGRWSAGIDGLVREHMIHPTVIITVMEEAALYGRVHQRVQLCLDCDKVSVLLSSLDFQPPKPQ 692

  Fly   326 RTVIFCSDDGDMQCLVAALEVQH-YSCLPYYQTADLEVRQQ--------VHSWQ---ARSNGVIL 378
            :|:|..:         :|.|.:| |..:.......|:..:.        :..|:   ::...|||
Zfish   693 KTLIITN---------SAEETEHVYKAVVNTAVFTLKAHEDATDQFDFIIDQWRKDISQGTQVIL 748

  Fly   379 LCTDNC-PELDIRDAHTIIHHSMSHSWSKFKLRHLKISDNLCNMVKPTASIVKKP-LYSLVLLDD 441
            :.|::| ..|.||||..::|:....:...|..|...:|:|...:.....|....| ..|::||.:
Zfish   749 VTTNDCLKALGIRDATCVVHYGFPSTPKLFGSRLFCMSENFRKLSDMDHSEDWTPGAQSVLLLSE 813

  Fly   442 NNHRQLPRLVDFL-QLHQKVDHRLVEVAKRIRQELGKARNDQHQ-LCDQILVLGKCYD-PVCESR 503
            .|.|.:..::.:| :....:...|::.|..|:|  .|.....|: ||..:...|.|.| .||..|
Zfish   814 QNVRHVCGVLRYLRRTGALLPPELLQFALGIQQ--AKEEQKTHRPLCCSLKSFGFCRDSTVCPDR 876

  Fly   504 HRL-SHIDRRPDYLPASGDVKVQLVKVYSPTHFCVRLLEHLPPKGTWRMMEYSAVQEFRMQLTQI 567
            |.: :.:|:  ..||.||.:.|..:.:.:.:.:|.|::.....     :.|..|.|   |:|...
Zfish   877 HTINTSLDQ--TQLPDSGMIMVLPLFIKTASVYCGRIVRQKED-----LYEDLATQ---MKLHYA 931

  Fly   568 KEPRRYWPPVAGAI-------CMYHTTFTKERVRVLKVAAIKNTNIVQSDLTVKLQALDVDTRIF 625
            .|.|.....:.||:       | ||      |||||:|.. |...:..|   |....:| :.|..
Zfish   932 SERRCAVEVLKGALYAIQEENC-YH------RVRVLEVPE-KGEQLFSS---VTACLID-EGRTQ 984

  Fly   626 STNCGKLFECPEALQQEAPLACDLRLPGWVPYFGERSWTEENIRNVNLILTQLPKDHFLQAKILF 690
            .....:|.:.|...|.....|.::.|....|..||..|..:..|.|:|.:    :....||:::.
Zfish   985 EVKSHQLLQLPAQFQDLPGQAVEIILCRVQPVDGEVDWNPKVTRAVSLKI----RGKLHQARVVM 1045

  Fly   691 VAAGTLFVQDLVAIMY-----ADQFKAHVRHL----SLARRLVEATLVKRSENAAEMIREFFA-- 744
            ....|::|..:|.|.:     ..:|...||.|    .|..|:|....:|...|...:..|..|
Zfish  1046 SLGNTIWVDPMVRIRHHGATNRPRFAGFVRFLFPLCGLQVRMVRVPGLKTFINEYNVHTEILASG 1110

  Fly   745 ------------EVIIEDDIDENVQDSK 760
                        :.:::.|.:.|:.|.:
Zfish  1111 FGVSNPQHVDLLKTVLQRDQNHNMLDQQ 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BoYb	NP_649430.1	P-loop_NTPase	81..263	CDD:304359	46/196 (23%)
tdrd12	XP_021326385.1	TUDOR	9..130	CDD:306940
		SrmB	463..>781	CDD:223587	77/353 (22%)
		TUDOR	912..1010	CDD:306940	27/117 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26337
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910