DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and CAN1

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_010851.1	Gene:	CAN1 / 856646	SGDID:	S000000789	Length:	590	Species:	Saccharomyces cerevisiae

Alignment Length:	569	Identity:	120/569 - (21%)
Similarity:	200/569 - (35%)	Gaps:	187/569 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DVNEGESQLARV---LNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGP-AVTISFLIAAIASAFA 75
            |.:|||.|.|.|   |....:..:.:|.|:|.|:::.......| ||| ...||:|.....:...
Yeast    73 DEDEGEVQNAEVKRELKQRHIGMIALGGTIGTGLFIGLSTPLTN-AGPVGALISYLFMGSLAYSV 136

  Fly    76 GICYAEFAARVPKAGSAYVYSYVTIGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLINNNMS 140
            .....|.|..:|...|..|:|.    .|::...|             .|.|...:|        |
Yeast   137 TQSLGEMATFIPVTSSFTVFSQ----RFLSPAFG-------------AANGYMYWF--------S 176

  Fly   141 KALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLNNIFTTVNL------------- 192
            .|:..::.:.|  :|....|.:: .|.|.|.|..|..        |.|.:||
Yeast   177 WAITFALELSV--VGQVIQFWTY-KVPLAAWISIFWV--------IITIMNLFPVKYYGEFEFWV 230

  Fly   193 VTIAIVLVAGAM--------NANVDN------WRIP--------KKDVPEGFGTGGFMPFGIAGV 235
            .:|.::.:.|.:        .|.|..      ||.|        .||..||         ...|.
Yeast   231 ASIKVLAIIGFLIYCFCMVCGAGVTGPVGFRYWRNPGAWGPGIISKDKNEG---------RFLGW 286

  Fly   236 MAGAAKCFYGFVGFDCIATTGEEAINPKRNIPLSI--VVSLIIIFLSYFGVSTVLTMMLPYYKQD 298
            ::......:.|.|.:.:..|..||.||::::|.:|  ||..|:.|  |.|....:.:::||....
Yeast   287 VSSLINAAFTFQGTELVGITAGEAANPRKSVPRAIKKVVFRILTF--YIGSLLFIGLLVPYNDPK 349

  Fly   299 --------KDAPF------------PHAFDSVEWYTIKWIVTIGAVFALCTSLLGA----MFPLP 339
                    ..:||            ||.|::|                :.|:::.|    ::...
Yeast   350 LTQSTSYVSTSPFIIAIENSGTKVLPHIFNAV----------------ILTTIISAANSNIYVGS 398

  Fly   340 RILYAMGKDGILFKRLSTVNSYTK--TPLLATIVSGIFASIMAMLFN------LDQLVDMMSIGT 396
            |||:.:.|:.:..|.||..   ||  .|.:|..|:..|.::..|..:      .:.|:::..:..
Yeast   399 RILFGLSKNKLAPKFLSRT---TKGGVPYIAVFVTAAFGALAYMETSTGGDKVFEWLLNITGVAG 460

  Fly   397 LLAYTIVAIC----VLVLRY----QDE-----------------EMTKLVSVKAPNVFRQFFNGN 436
            ..|:..::|.    :..|:|    :||                 .||.::.::....|...|||.
Yeast   461 FFAWLFISISHIRFMQALKYRGISRDELPFKAKLMPGLAYYAATFMTIIIIIQGFTAFAPKFNGV 525

  Fly   437 SFREPNSMTSSITKVGIVVFAIFCLVWCSLQKVF-----------DLDS 474
            ||          ....|.:| :|..||...|.:|           |:||
Yeast   526 SF----------AAAYISIF-LFLAVWILFQCIFRCRFIWKIGDVDIDS 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	120/569 (21%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
CAN1	NP_010851.1	2A0310	85..562	CDD:273334	111/554 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345709
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.890