DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slif and PUT4

DIOPT Version :9

Sequence 1:	NP_649428.1	Gene:	slif / 40510	FlyBaseID:	FBgn0037203	Length:	604	Species:	Drosophila melanogaster
Sequence 2:	NP_014993.1	Gene:	PUT4 / 854530	SGDID:	S000005875	Length:	627	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	114/542 - (21%)
Similarity:	203/542 - (37%)	Gaps:	116/542 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 EGESQ---LARVLNLFDLTALGVGSTLGLGVYVLAGQVAFNIAGPA-VTISFLIAAIASAFAGIC 78
            :|:|:   |.:.|....:..:.:|..:|.|:.| ......:..||| :.||::|.: |..:..:|
Yeast    98 DGDSEPHKLKQGLQSRHVQLIALGGAIGTGLLV-GTSSTLHTCGPAGLFISYIIIS-AVIYPIMC 160

  Fly    79 -YAEFAARVPKAGS---AYVYSYVT--IGEFVAFTIGWNLILEYVIGTASVARGLSGYFDSLINN 137
             ..|....:|..||   ....:.||  :...:.|..|||....|||..|:.....||     :..
Yeast   161 ALGEMVCFLPGDGSDSAGSTANLVTRYVDPSLGFATGWNYFYCYVILVAAECTAASG-----VVE 220

  Fly   138 NMSKALNESMHIDVDFLGDYPDFLSFGMVLLLAAILAFGAKESSFLN-NIFTTVNLVTIAIVLVA 201
            ..:.|:.:.:.|.:        ||...::|..:|:..:|..|..|.: .|...|.|:.::.:|..
Yeast   221 YWTTAVPKGVWITI--------FLCVVVILNFSAVKVYGESEFWFASIKILCIVGLIILSFILFW 277

  Fly   202 GAMNANVDNWRIPKKDVPEGFG---TGGFMPFGIAGVMAGAAKCFYGFV-GFDCIATTGEEAINP 262
            |. ..|.|.........|..|.   |||.:. ....:..|..|..:.|: |.:.:..|..|..:.
Yeast   278 GG-GPNHDRLGFRYWQHPGAFAHHLTGGSLG-NFTDIYTGIIKGAFAFILGPELVCMTSAECADQ 340

  Fly   263 KRNIPLS---IVVSLIIIFLSYFGVSTVLTMMLPY--------YKQDK----DAPFPHAFDSVEW 312
            :|||..:   .|..||..::  .| :..:::::||        ..|.|    .:||.....:...
Yeast   341 RRNIAKASRRFVWRLIFFYV--LG-TLAISVIVPYNDPTLVNALAQGKPGAGSSPFVIGIQNAGI 402

  Fly   313 YTIKWIVTIGAVFALCTSLLGA-MFPLPRILYAMGKDGILFKRLSTVNSYTKTPLLATIVSGIFA 376
            ..:..|:. |.:.....|...| ||...|.|..|.:.|...|.|..:|.: ..|.:|..|| ...
Yeast   403 KVLPHIIN-GCILTSAWSAANAFMFASTRSLLTMAQTGQAPKCLGRINKW-GVPYVAVGVS-FLC 464

  Fly   377 SIMAMLFNLDQLVDMM----SIGTLLAYT-IVAICVLVLRYQDEEMTKLVSVKAPNVFRQFFNG- 435
            |.:|.|.......|:.    :|.|:..:. .:..|:..||::     |.:          |:||
Yeast   465 SCLAYLNVSSSTADVFNWFSNISTISGFLGWMCGCIAYLRFR-----KAI----------FYNGL 514

  Fly   436 ------NSFREPNSMTSSITKVGIVVFA------------------------IFCLVWCSLQ--- 467
                  .::.:|.::..|:..:||:...                        ||.::|...:
Yeast   515 YDRLPFKTWGQPYTVWFSLIVIGIITITNGYAIFIPKYWRVADFIAAYITLPIFLVLWFGHKLYT 579

  Fly   468 --------KVFDLDSTGGIVAL 481
                    .|.::|.|.|:|.:
Yeast   580 RTWRQWWLPVSEIDVTTGLVEI 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slif	NP_649428.1	2A0303	8..557	CDD:273330	114/542 (21%)
slif	NP_649428.1	AA_permease_C	507..557	CDD:290617
PUT4	NP_014993.1	2A0310	107..593	CDD:273334	107/523 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960